AID Recognizes Structured DNA for Class Switch Recombination.

[1]  Rommie E. Amaro,et al.  Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B , 2016, Nature Structural &Molecular Biology.

[2]  Shu-xing Li,et al.  Crystal structures of APOBEC3G N-domain alone and its complex with DNA , 2016, Nature Communications.

[3]  L. Pedersen,et al.  Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification. , 2016, DNA repair.

[4]  T. Honjo,et al.  Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins , 2016, Proceedings of the National Academy of Sciences.

[5]  Jennifer A. Doudna,et al.  Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage , 2016, Science.

[6]  Thomas B. Kepler,et al.  Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes , 2015, Cell.

[7]  G. Smith,et al.  High-throughput sequencing of DNA G-quadruplex structures in the human genome , 2015, Nature Biotechnology.

[8]  J. Chaudhuri,et al.  Non-coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA , 2015, Cell.

[9]  H. Lucas,et al.  Catalytic pocket inaccessibility of activation-induced cytidine deaminase is a safeguard against excessive mutagenic activity. , 2015, Structure.

[10]  F. Alt,et al.  Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination , 2015, Microbiology spectrum.

[11]  James E. Bradner,et al.  Convergent Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability , 2014, Cell.

[12]  Yijun Ruan,et al.  B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity , 2014, Cell.

[13]  J. Chaudhuri,et al.  Binding of AID to DNA Does Not Correlate with Mutator Activity , 2014, The Journal of Immunology.

[14]  M. Santiago,et al.  Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection , 2014, Proceedings of the National Academy of Sciences.

[15]  R. Kohli,et al.  Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase , 2013, Proceedings of the National Academy of Sciences.

[16]  D. Schatz,et al.  Multiple Transcription Factor Binding Sites Predict AID Targeting in Non-Ig Genes , 2013, The Journal of Immunology.

[17]  N. Maizels,et al.  The G4 Genome , 2013, PLoS genetics.

[18]  W. Sugiura,et al.  The APOBEC3C crystal structure and the interface for HIV-1 Vif binding , 2012, Nature Structural &Molecular Biology.

[19]  P. Casali,et al.  Immunoglobulin class-switch DNA recombination: induction, targeting and beyond , 2012, Nature Reviews Immunology.

[20]  J. Kypr,et al.  Circular dichroism and guanine quadruplexes. , 2012, Methods.

[21]  Kefei Yu,et al.  Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination , 2011, Proceedings of the National Academy of Sciences.

[22]  Randy J. Read,et al.  Overview of the CCP4 suite and current developments , 2011, Acta crystallographica. Section D, Biological crystallography.

[23]  Vasco M. Barreto,et al.  Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5 , 2010, Cell.

[24]  J. Yates,et al.  14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′-rich switch regions for class switch recombination , 2010, Nature Structural &Molecular Biology.

[25]  M. Neuberger,et al.  Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID , 2010, The Journal of experimental medicine.

[26]  R. Maul,et al.  A Portable Hot Spot Recognition Loop Transfers Sequence Preferences from APOBEC Family Members to Activation-induced Cytidine Deaminase* , 2009, The Journal of Biological Chemistry.

[27]  M. Wang,et al.  AID up-mutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity , 2009, Nature Structural &Molecular Biology.

[28]  F. Alt,et al.  Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice , 2009, Proceedings of the National Academy of Sciences.

[29]  T. Honjo,et al.  Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants , 2008, Proceedings of the National Academy of Sciences.

[30]  J. Leroy,et al.  The formation pathway of tetramolecular G-quadruplexes , 2007, Nucleic acids research.

[31]  T. Mueser,et al.  Crystal Structure of Bacteriophage T4 5′ Nuclease in Complex with a Branched DNA Reveals How Flap Endonuclease-1 Family Nucleases Bind Their Substrates* , 2007, Journal of Biological Chemistry.

[32]  N. Maizels,et al.  G-rich proto-oncogenes are targeted for genomic instability in B-cell lymphomas. , 2007, Cancer research.

[33]  A. Fischer,et al.  Activation‐induced cytidine deaminase: structure–function relationship as based on the study of mutants , 2006, Human mutation.

[34]  Alberto Martin,et al.  AID Associates with Single-Stranded DNA with High Affinity and a Long Complex Half-Life in a Sequence-Independent Manner , 2006, Molecular and Cellular Biology.

[35]  F. Alt,et al.  The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation , 2005, Nature.

[36]  N. Maizels,et al.  AID binds to transcription-induced structures in c-MYC that map to regions associated with translocation and hypermutation , 2005, Oncogene.

[37]  Alberto Martin,et al.  The mutation spectrum of purified AID is similar to the mutability index in Ramos cells and in ung−/−msh2−/− mice , 2005, Immunogenetics.

[38]  F. Alt,et al.  Replication protein A interacts with AID to promote deamination of somatic hypermutation targets , 2004, Nature.

[39]  F. Alt,et al.  Class-switch recombination: interplay of transcription, DNA deamination and DNA repair , 2004, Nature Reviews Immunology.

[40]  N. Maizels,et al.  Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA. , 2004, Genes & development.

[41]  I. Rogozin,et al.  Cutting Edge: DGYW/WRCH Is a Better Predictor of Mutability at G:C Bases in Ig Hypermutation Than the Widely Accepted RGYW/WRCY Motif and Probably Reflects a Two-Step Activation-Induced Cytidine Deaminase-Triggered Process , 2004, The Journal of Immunology.

[42]  M. Goodman,et al.  Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation , 2003, Nature.

[43]  M. Lieber,et al.  R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells , 2003, Nature Immunology.

[44]  F. Alt,et al.  Transcription-targeted DNA deamination by the AID antibody diversification enzyme , 2003, Nature.

[45]  M. Goodman,et al.  Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[46]  M. Neuberger,et al.  AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification , 2002, Nature.

[47]  A Cumano,et al.  Evolutionary and somatic selection of the antibody repertoire in the mouse. , 1987, Science.

[48]  L. Staudt,et al.  Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[49]  J. Chaudhuri,et al.  Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair. , 2014, Advances in immunology.

[50]  T. Honjo,et al.  The AID dilemma: infection, or cancer? , 2012, Advances in cancer research.

[51]  P. Emsley,et al.  Features and development of Coot , 2010, Acta crystallographica. Section D, Biological crystallography.

[52]  Yong Zhou,et al.  Roll: a new algorithm for the detection of protein pockets and cavities with a rolling probe sphere , 2010, Bioinform..

[53]  L. Hurley,et al.  Biochemical techniques for the characterization of G-quadruplex structures: EMSA, DMS footprinting, and DNA polymerase stop assay. , 2010, Methods in molecular biology.

[54]  Vincent B. Chen,et al.  Acta Crystallographica Section D Biological , 2001 .