MicroRNA-23b plays a tumor suppressive role in Cutaneous Squamous Cell Carcinoma and targets Ras-related protein RRAS2.

[1]  F. Végran,et al.  Role of Cytokines and Chemokines in Angiogenesis in a Tumor Context , 2022, Cancers.

[2]  A. Keller,et al.  Emerging concepts of miRNA therapeutics: from cells to clinic. , 2022, Trends in genetics : TIG.

[3]  J. Lapins,et al.  MicroRNA-130a acts as a tumor suppressive miRNA in cutaneous squamous cell carcinoma and regulates the activity of the BMP/SMAD1 pathway by suppressing ACVR1. , 2021, The Journal of investigative dermatology.

[4]  A. Jemal,et al.  Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries , 2021, CA: a cancer journal for clinicians.

[5]  G. Inman,et al.  The Genomic Landscape of Actinic Keratosis , 2021, The Journal of investigative dermatology.

[6]  J. Lapins,et al.  A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma , 2020, Scientific Reports.

[7]  O. Peralta-Zaragoza,et al.  MiR-23b-3p reduces the proliferation, migration and invasion of cervical cancer cell lines via the reduction of c-Met expression , 2020, Scientific Reports.

[8]  C. Longo,et al.  Molecular genetics of cutaneous squamous cell carcinoma: perspective for treatment strategies , 2019, Journal of the European Academy of Dermatology and Venereology : JEADV.

[9]  L. Pasquali,et al.  Next generation sequencing identifies the keratinocyte-specific miRNA signature of psoriasis. , 2019, The Journal of investigative dermatology.

[10]  H. Cavé,et al.  Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome. , 2019, American journal of human genetics.

[11]  N. Katsanis,et al.  Germline-Activating RRAS2 Mutations Cause Noonan Syndrome. , 2019, American journal of human genetics.

[12]  Jie Yang,et al.  miR-23 regulates cell proliferation and apoptosis of vascular smooth muscle cells in coronary heart disease. , 2018, Pathology, research and practice.

[13]  Chi-Hung Lin,et al.  MicroRNA-23a/27a/24-2 cluster promotes gastric cancer cell proliferation synergistically , 2018, Oncology letters.

[14]  D. Bartel.  Metazoan MicroRNAs , 2018, Cell.

[15]  L. Barbollat-Boutrand,et al.  MicroRNA‐23b‐3p regulates human keratinocyte differentiation through repression of TGIF1 and activation of the TGF‐ß–SMAD2 signalling pathway , 2017, Experimental dermatology.

[16]  J. Lapins,et al.  MicroRNA-203 Inversely Correlates with Differentiation Grade, Targets c-MYC, and Functions as a Tumor Suppressor in cSCC. , 2016, The Journal of investigative dermatology.

[17]  M. Loh,et al.  Germline RRAS2 mutations are not associated with Noonan syndrome , 2016, Journal of Medical Genetics.

[18]  Yong Peng,et al.  The role of MicroRNAs in human cancer , 2016, Signal Transduction and Targeted Therapy.

[19]  X. Lü,et al.  microRNA regulatory mechanism by which PLLA aligned nanofibers influence PC12 cell differentiation , 2015, Journal of neural engineering.

[20]  Y. Shang,et al.  miR-23b-3p regulates the chemoresistance of gastric cancer cells by targeting ATG12 and HMGB2 , 2015, Cell Death and Disease.

[21]  Chang Liu,et al.  An Exploration of Evolution, Maturation, Expression and Function Relationships in Mir-23∼27∼24 Cluster , 2014, PloS one.

[22]  Romain M. Larive,et al.  Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease , 2014, Nature Communications.

[23]  M. Loh,et al.  Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis , 2014, Human molecular genetics.

[24]  Michael J. Atkinson,et al.  UVA and UVB Irradiation Differentially Regulate microRNA Expression in Human Primary Keratinocytes , 2013, PloS one.

[25]  R. Hamoudi,et al.  Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling , 2013, British Journal of Cancer.

[26]  A. Jegga,et al.  Identification of new p53 target microRNAs by bioinformatics and functional analysis , 2013, BMC Cancer.

[27]  Shuxia Zhao,et al.  Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. , 2013, Cancer discovery.

[28]  R. Dahiya,et al.  miR-23b represses proto-oncogene Src kinase and functions as methylation-silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer. , 2012, Cancer research.

[29]  D. Grandér,et al.  MicroRNA-125b Down-regulates Matrix Metallopeptidase 13 and Inhibits Cutaneous Squamous Cell Carcinoma Cell Proliferation, Migration, and Invasion* , 2012, The Journal of Biological Chemistry.

[30]  Romain M. Larive,et al.  The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development , 2012, Molecular biology of the cell.

[31]  Changhong Sun,et al.  Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis. , 2011, Nature communications.

[32]  D. W. Kim,et al.  Greater expression of TC21/R‐ras2 in highly aggressive malignant skin cancer , 2011, International journal of dermatology.

[33]  E. Olson,et al.  Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23∼27∼24 clusters , 2011, Proceedings of the National Academy of Sciences.

[34]  L. Cranmer,et al.  Treatment of unresectable and metastatic cutaneous squamous cell carcinoma. , 2010, The oncologist.

[35]  N. Saini,et al.  Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases , 2010, Molecular Cancer.

[36]  S. Euvrard,et al.  Organ transplantation and skin cancer: basic problems and new perspectives , 2010, Experimental dermatology.

[37]  C. Burge,et al.  Most mammalian mRNAs are conserved targets of microRNAs. , 2008, Genome research.

[38]  H. Ruohola-Baker,et al.  Stem cell division is regulated by the microRNA pathway , 2005, Nature.

[39]  H. Horvitz,et al.  MicroRNA expression profiles classify human cancers , 2005, Nature.

[40]  S. Lippman,et al.  Mortality risk from squamous cell skin cancer. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[41]  D. Bartel.  MicroRNAs Genomics, Biogenesis, Mechanism, and Function , 2004, Cell.

[42]  R. Russell,et al.  bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila , 2003, Cell.

[43]  Michelle L. Varney,et al.  IL-8 Directly Enhanced Endothelial Cell Survival, Proliferation, and Matrix Metalloproteinases Production and Regulated Angiogenesis1 , 2003, The Journal of Immunology.

[44]  Jean-Paul Ortonne,et al.  From actinic keratosis to squamous cell carcinoma , 2002, The British journal of dermatology.

[45]  D Ratner,et al.  Cutaneous squamous-cell carcinoma. , 2001, The New England journal of medicine.

[46]  F. Hobbs,et al.  Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase* , 1998, The Journal of Biological Chemistry.

[47]  Y. Kubo,et al.  p53 gene mutations in human skin cancers and precancerous lesions: comparison with immunohistochemical analysis. , 1994, The Journal of investigative dermatology.

[48]  W. Deppert,et al.  A comprehensive analysis of microRNA expression during human keratinocyte differentiation in vitro and in vivo. , 2011, The Journal of investigative dermatology.

[49]  C. Cockerell,et al.  Histopathology of incipient intraepidermal squamous cell carcinoma ("actinic keratosis"). , 2000, Journal of the American Academy of Dermatology.