Stereoselective Complete Reduction of a-Alkyl--ketonitriles toanti ?-Amino Alcohols

The one-pot reduction of α-alkyl-β-ketonitriles to anti γ-amino alcohols can be efficiently performed by borane/dimethyl sulfide complex in the presence of cerium chloride as Lewis acid. Selectivities are slightly worse than monoreduction but this drawback is overcome by much better yields. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)

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