Nanomedicine: nanocarriers shape up for long life.

Keeping drug-delivery vehicles in the bloodstream for a long time is a challenge. New results suggest that adopting the filamentous shape of viruses may lead to better nanocarriers.

[1]  Alexander V Kabanov,et al.  Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier. , 2003, Advanced drug delivery reviews.

[2]  R. Duncan.  The dawning era of polymer therapeutics , 2003, Nature Reviews Drug Discovery.

[3]  G. Kwon,et al.  Polymeric micelles for drug delivery. , 2006, Current pharmaceutical design.

[4]  R. Jain,et al.  Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Dennis E. Discher,et al.  Polymer vesicles : Materials science: Soft surfaces , 2002 .

[6]  M. Prato,et al.  Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[7]  Kazunori Kataoka,et al.  Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. , 2006, Pharmacology & therapeutics.

[8]  M. Ferrari.  Cancer nanotechnology: opportunities and challenges , 2005, Nature Reviews Cancer.

[9]  Y. Barenholz,et al.  Development of liposomal anthracyclines: from basics to clinical applications. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[10]  D. Discher,et al.  Shape effects of filaments versus spherical particles in flow and drug delivery. , 2007, Nature nanotechnology.