CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis.
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Charles M Perou | Matthew D. Smith | Feng Bai | Yue Xiong | C. Fan | C. Perou | S. Pai | Y. Xiong | X. Pei | F. Bai | J. Usary | I. Ho | Cheng Fan | Xin-Hai Pei | Matthew D Smith | Jerry Usary | Sung-Yun Pai | I-Cheng Ho | Jerry E. Usary
[1] R. Tibshirani,et al. Repeated observation of breast tumor subtypes in independent gene expression data sets , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[2] R. Ullrich,et al. Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice: the difference is as clear as black and white. , 1997, Radiation research.
[3] M. García-Closas,et al. Etiology of hormone receptor-defined breast cancer: a systematic review of the literature. , 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
[4] A. Ashworth,et al. Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland , 2007, The Journal of cell biology.
[5] A. Nobel,et al. Concordance among Gene-Expression – Based Predictors for Breast Cancer , 2011 .
[6] Howard Y. Chang,et al. Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[7] G. Stamp,et al. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. , 1995, Genes & development.
[8] Emma Lees,et al. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice , 1994, Nature.
[9] C. Eaves,et al. Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue , 2001, Breast Cancer Research and Treatment.
[10] P. Pandolfi,et al. p18Ink4c and Pten Constrain a Positive Regulatory Loop between Cell Growth and Cell Cycle Control , 2006, Molecular and Cellular Biology.
[11] Marie-Liesse Asselin-Labat,et al. Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation , 2007, Nature Cell Biology.
[12] M. Hatten,et al. The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. , 2005, Genes & development.
[13] E. Harlow,et al. Monoclonal antibodies specific for underphosphorylated retinoblastoma protein identify a cell cycle regulated phosphorylation site targeted by CDKs , 1997, Oncogene.
[14] Yudong D. He,et al. A Gene-Expression Signature as a Predictor of Survival in Breast Cancer , 2002 .
[15] K. Ligon,et al. p16INK4a induces an age-dependent decline in islet regenerative potential , 2006, Nature.
[16] Gilbert H. Smith,et al. Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands , 2005, Development.
[17] G. Dontu,et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. , 2003, Genes & development.
[18] Zhiyuan Hu,et al. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors , 2007, Genome Biology.
[19] V. Godfrey,et al. Haploinsufficiency of p18INK4c Sensitizes Mice to Carcinogen-Induced Tumorigenesis , 2003, Molecular and Cellular Biology.
[20] D. Carrasco,et al. Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues. , 2007, Cancer research.
[21] R. DePinho,et al. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a , 2006, Nature.
[22] François Vaillant,et al. Generation of a functional mammary gland from a single stem cell , 2006, Nature.
[23] A. Ashworth,et al. CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells , 2005, Breast Cancer Research.
[24] V. Godfrey,et al. CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. , 1998, Genes & development.
[25] E. Ramsay,et al. Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[26] A. Nobel,et al. The molecular portraits of breast tumors are conserved across microarray platforms , 2006, BMC Genomics.
[27] M. Barbacid,et al. Limited overlapping roles of P15INK4b and P18INK4c cell cycle inhibitors in proliferation and tumorigenesis , 2000, The EMBO journal.
[28] D. Medina,et al. A morphologically distinct candidate for an epithelial stem cell in mouse mammary gland. , 1988, Journal of cell science.
[29] Matthew D. Smith,et al. p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers. , 2007, Cancer research.
[30] Christian A. Rees,et al. Molecular portraits of human breast tumours , 2000, Nature.
[31] Haiyan I. Li,et al. Purification and unique properties of mammary epithelial stem cells , 2006, Nature.
[32] R. Tibshirani,et al. Copyright © American Society for Investigative Pathology Short Communication Expression of Cytokeratins 17 and 5 Identifies a Group of Breast Carcinomas with Poor Clinical Outcome , 2022 .
[33] E. Ramsay,et al. Cdkn 2 a , the cyclin-dependent kinase inhibitor encoding p 16 INK 4 a and p 19 ARF , is a candidate for the plasmacytoma susceptibility locus , Pctr 1 , 1998 .
[34] S. Pai,et al. Critical roles for transcription factor GATA-3 in thymocyte development. , 2003, Immunity.
[35] S. Morrison,et al. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing , 2006, Nature.
[36] Zena Werb,et al. GATA-3 Maintains the Differentiation of the Luminal Cell Fate in the Mammary Gland , 2006, Cell.
[37] D. Carrasco,et al. Expression of p 16 Ink 4 a Compensates for p 18 Ink 4 c Loss in Cyclin-Dependent Kinase 4 / 6 – Dependent Tumors and Tissues , 2007 .
[38] T. Graubert,et al. Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population. , 2002, Developmental biology.
[39] K. Leibundgut,et al. MCM4 shares homology to a replication/DNA-binding domain in CTF and is contacted by pRb. , 2004, Biochemical and biophysical research communications.
[40] Z. Werb,et al. GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. , 2008, Cancer cell.
[41] F. Zindy,et al. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging , 1997, Oncogene.
[42] Y. Geng,et al. Specific protection against breast cancers by cyclin D1 ablation , 2001, Nature.
[43] Robert L. Sutherland,et al. Cyclin D1, EMS1 and 11q13 Amplification in Breast Cancer , 2003, Breast Cancer Research and Treatment.
[44] R. Ullrich,et al. Strain-dependent susceptibility to radiation-induced mammary cancer is a result of differences in epithelial cell sensitivity to transformation. , 1996, Radiation research.
[45] R. Dickson,et al. Differential alteration of stem and other cell populations in ducts and lobules of TGFalpha and c-Myc transgenic mouse mammary epithelium. , 2005, Tissue & cell.
[46] Debashis Ghosh,et al. Identification of GATA3 as a breast cancer prognostic marker by global gene expression meta-analysis. , 2005, Cancer research.
[47] N. Sharpless,et al. Ink4a/Arf expression is a biomarker of aging. , 2004, The Journal of clinical investigation.
[48] C. Sherr. Cancer Cell Cycles , 1996, Science.
[49] S. Elledge,et al. Cyclin D1 provides a link between development and oncogenesis in the retina and breast , 1995, Cell.
[50] Yan Geng,et al. Requirement for CDK4 kinase function in breast cancer. , 2006, Cancer cell.