DNA methylation and autoimmune disease.

[1]  S. Hanash,et al.  DNA Methylation and Chromatin Structure Regulate T Cell Perforin Gene Expression1 , 2003, The Journal of Immunology.

[2]  Zhiyong Zhang,et al.  Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling. , 2003, Arthritis & Rheumatism.

[3]  W. Mccune,et al.  The Apoptotic Ligands TRAIL, TWEAK, and Fas Ligand Mediate Monocyte Death Induced by Autologous Lupus T Cells1 , 2002, The Journal of Immunology.

[4]  Richard O Hynes,et al.  Integrins Bidirectional, Allosteric Signaling Machines , 2002, Cell.

[5]  S. Santangelo,et al.  DNA Methylation Changes at Human Th2 Cytokine Genes Coincide with DNase I Hypersensitive Site Formation During CD4+ T Cell Differentiation1 , 2002, The Journal of Immunology.

[6]  M. Ehrlich,et al.  DNA methylation in cancer: too much, but also too little , 2002, Oncogene.

[7]  B. Richardson,et al.  Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancer. , 2002, The Journal of nutrition.

[8]  D. Gutsch,et al.  Effect of DNA methylation and chromatin structure on ITGAL expression , 2002 .

[9]  A. Perl,et al.  Abnormal T cell signal transduction in systemic lupus erythematosus. , 2002, Arthritis and rheumatism.

[10]  Suneet Agarwal,et al.  Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. , 2002, Immunity.

[11]  D. Gutsch,et al.  Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus. , 2002, Arthritis and rheumatism.

[12]  R. Yung,et al.  DNA methylation and the regulation of gene transcription , 2002, Cellular and Molecular Life Sciences CMLS.

[13]  Peter A. Jones DNA methylation and cancer , 2002, Oncogene.

[14]  S. Piantadosi,et al.  Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide. , 2001, Cancer research.

[15]  M. Kaplan,et al.  Autoreactive murine Th1 and Th2 cells kill syngeneic macrophages and induce autoantibodies , 2001, Lupus.

[16]  A. Rosen,et al.  Clearing the way to mechanisms of autoimmunity , 2001, Nature Medicine.

[17]  S. Hanash,et al.  Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. , 2001, Arthritis and rheumatism.

[18]  L. Beretta,et al.  LFA-1 overexpression and T cell autoreactivity: mechanisms. , 2000, Immunological investigations.

[19]  M. Walport Lupus, DNase and defective disposal of cellular debris , 2000, Nature Genetics.

[20]  M. Kaplan,et al.  TRAIL (Apo2 Ligand) and TWEAK (Apo3 Ligand) Mediate CD4+ T Cell Killing of Antigen-Presenting Macrophages1 , 2000, The Journal of Immunology.

[21]  B. Richardson,et al.  Role of DNA methylation in the regulation of cell function. , 1999, The Journal of laboratory and clinical medicine.

[22]  P. Butler,et al.  Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity , 1999, Nature Medicine.

[23]  Chyung-Ru Wang,et al.  Helper T cell differentiation is controlled by the cell cycle. , 1998, Immunity.

[24]  D. Mevorach,et al.  Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production , 1998, The Journal of experimental medicine.

[25]  L. E. McDonald,et al.  Distinct Methylation of the Interferon γ (IFN-γ) and Interleukin 3 (IL-3) Genes in Newly Activated Primary CD8+ T Lymphocytes: Regional IFN-γ Promoter Demethylation and mRNA Expression Are Heritable in CD44highCD8+ T Cells , 1998, The Journal of experimental medicine.

[26]  B. Richardson,et al.  Mechanisms of drug-induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo. , 1997, Arthritis and rheumatism.

[27]  R. Yung,et al.  Mechanisms of drug-induced lupus. III. Sex-specific differences in T cell homing may explain increased disease severity in female mice. , 1997, Arthritis and rheumatism.

[28]  S. Shichijo,et al.  Induction of MAGE Genes in Lymphoid Cells by the Demethylating Agent 5‐Aza‐2′‐deoxycytidine , 1996, Japanese journal of cancer research : Gann.

[29]  E. Amento,et al.  Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice. , 1996, The Journal of clinical investigation.

[30]  R. Herrera,et al.  Adhesion through the Interaction of Lymphocyte Function-associated Antigen-1 with Intracellular Adhesion Molecule-1 Induces Tyrosine Phosphorylation of p130 and Its Association with c-CrkII (*) , 1996, The Journal of Biological Chemistry.

[31]  C. Morimoto,et al.  CD27-CD70 interactions regulate B-cell activation by T cells. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[32]  B. Richardson,et al.  Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo. , 1995, Journal of immunology.

[33]  N. Lalwani,et al.  Fas ligation triggers apoptosis in macrophages but not endothelial cells , 1994, European journal of immunology.

[34]  S. Clark,et al.  High sensitivity mapping of methylated cytosines. , 1994, Nucleic acids research.

[35]  K. O'rourke,et al.  Lymphocyte function-associated antigen 1 overexpression and T cell autoreactivity. , 1994, Arthritis and rheumatism.

[36]  T. Takeuchi,et al.  Upregulated expression and function of integrin adhesive receptors in systemic lupus erythematosus patients with vasculitis. , 1993, The Journal of clinical investigation.

[37]  E. Amento,et al.  Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice. , 1993, The Journal of clinical investigation.

[38]  B. Richardson,et al.  Evidence that macrophages are programmed to die after activating autologous, cloned, antigen‐specific, CD4+ T cells , 1993, European journal of immunology.

[39]  S. Hanash,et al.  Phenotypic and functional similarities between 5-azacytidine-treated T cells and a T cell subset in patients with active systemic lupus erythematosus. , 1992, Arthritis and rheumatism.

[40]  B. Richardson,et al.  Procainamide inhibits DNA methyltransferase in a human T cell line. , 1991, The Journal of rheumatology.

[41]  S Hanash,et al.  Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. , 1990, Arthritis and rheumatism.

[42]  J. Hudson,et al.  CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation. , 1990, Clinical immunology and immunopathology.

[43]  J. Trowsdale,et al.  Cotransfection of ICAM-1 and HLA-DR reconstitutes human antigen-presenting cell function in mouse L cells , 1989, Nature.

[44]  R. Coffman,et al.  Heterogeneity of cytokine secretion patterns and functions of helper T cells. , 1989, Advances in immunology.

[45]  S. Hanash,et al.  Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. , 1988, Journal of immunology.

[46]  R. Coffman,et al.  IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses. , 1988, Journal of immunology.

[47]  J. Hudson,et al.  Increased immunoglobulin response to gamma-interferon by lymphocytes from patients with systemic lupus erythematosus. , 1988, Clinical immunology and immunopathology.

[48]  B. Leyland-Jones,et al.  Biochemistry of azacitidine: a review. , 1987, Cancer treatment reports.

[49]  M. Sneller,et al.  DNA methylation alters chromatin structure and regulates Thy-1 expression in EL-4 T cells. , 1987, Journal of immunology.

[50]  B. Richardson,et al.  Effect of an inhibitor of DNA methylation on T cells. II. 5-Azacytidine induces self-reactivity in antigen-specific T4+ cells. , 1986, Human immunology.

[51]  S. Pals,et al.  Chronic progressive polyarthritis and other symptoms of collagen vascular disease induced by graft-vs-host reaction. , 1985, Journal of immunology.

[52]  T. Hirano,et al.  Effect of recombinant IL 2 and gamma-IFN on proliferation and differentiation of human B cells. , 1985, Journal of immunology.

[53]  T. Waldmann,et al.  Activators of protein kinase C and 5‐azacytidine induce IL‐2 receptor expression on human T lymphocytes , 1985, Journal of cellular biochemistry.

[54]  Z. Ballas The use of 5-azacytidine to establish constitutive interleukin 2-producing clones of the EL4 thymoma. , 1984, Journal of immunology.

[55]  P. Jones,et al.  Mechanism of action of eukaryotic DNA methyltransferase. Use of 5-azacytosine-containing DNA. , 1982, Journal of molecular biology.

[56]  E. Gleichmann,et al.  Diseases caused by reactions of T lymphocytes towards incompatible structures of the major histocompatibility complex. VI. Autoantibodies characteristic of systemic lupus erythematosus induced by abnormal T-B cell cooperation across I-E , 1982, The Journal of experimental medicine.

[57]  R. Palmiter,et al.  DNA methylation controls the inducibility of the mouse metallothionein-I gene in lymphoid cells , 1981, Cell.