Journal Pre-proof Characteristics, Treatment Patterns, and Clinical Outcomes After Heart Failure Hospitalizations in COVID-19 Pandemic, 2020

Objective To compare clinical characteristics, treatment patterns, and 30-day all-cause readmission and mortality between patients hospitalized for heart failure (HF) before and during the COVID-19 pandemic. Methods The study was conducted at 16 hospitals across 3 geographically dispersed US states. The study included 6769 adults (mean age, 74 years; 56% men) with cumulative 8989 HF hospitalizations: 2341 hospitalizations in COVID-19 pandemic (Mar- Oct 2020) and 6648 in the pre-COVID-19 (Oct 2018 – Feb 2020) comparator group. We used Poisson regression, Kaplan-Meier estimates, multivariable logistic, and Cox regression analysis to determine whether pre-specified study outcomes vary by timeframes. Socio-demographic indicators. Data-related to age, sex at birth (male and female), race (white and non-white), marital status (married and others), and body mass index (BMI). Physiological and laboratory measures . Values for systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, blood urea nitrogen (BUN), and creatinine on the day of admission. An average of 3 consecutive measurements of SBP, DBP, or heart rate were used for data analysis.

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