LTP and memory: can we enhance the connection?

ploration-induced effects are short lived, leading to the name 'shortterm exploratory modulation' (STEM). In addition, while both LTP and STEM are characterized by an increased EPSP, they differ with respect to the evoked population spike, which is enhanced in LTP, and reduced in STEM. However, this discrepancy was interpreted as STEM involving the summed strengthening of synapses on a select few excitatory cells and on many inhibitory cells that produce a feedforward inhibition 5. These exciting discoveries, combined with replications of STEM, including controls for EEG state and locomotion 5, caused many of us to embrace the notion that STEM might reflect specific information processing. Enthusiasm was further raised by a neuro

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