Serum eye drops: a survey of international production methods

Serum eye drops (SEDs) are used to treat dry eye syndrome and non‐healing corneal lesions when other treatments fail. Despite many clinical studies demonstrating the efficacy of both autologous and allogeneic SEDs, there is no internationally harmonized method for producing SEDs.

[1]  Ching-Li Tseng,et al.  Reflections on Dry Eye Syndrome Treatment: Therapeutic Role of Blood Products , 2018, Front. Med..

[2]  M. Cifuentes,et al.  Regenerative Therapies in Dry Eye Disease: From Growth Factors to Cell Therapy , 2017, International journal of molecular sciences.

[3]  M. Méndez,et al.  Stability of Growth Factors in Autologous Serum Eyedrops After Long-Term Storage , 2015, Current eye research.

[4]  J. Bartlett,et al.  Ophthalmic Procedures for Treatment of Advanced Ocular Surface Diseases. , 2015, Optometry and vision science : official publication of the American Academy of Optometry.

[5]  G. Sivertsen,et al.  Implementation of a standardised method for the production of allogeneic serum eye drops from regular blood donors in a Norwegian University Hospital: Some methodological aspects and clinical considerations. , 2015, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[6]  D. Branch,et al.  Anti‐A and anti‐B: what are they and where do they come from? , 2015, Transfusion.

[7]  R. Cardigan,et al.  Thawed and liquid plasma – what do we know? , 2015, Vox sanguinis.

[8]  Karam A. Alawa,et al.  Therapeutic Strategies to Treat Dry Eye in an Aging Population , 2015, Drugs & Aging.

[9]  Na Hee Kang,et al.  Comparison of epitheliotrophic factors in autologous serum eyedrops from sera of chronic renal failure patients vs. normal controls , 2015, Graefe's Archive for Clinical and Experimental Ophthalmology.

[10]  M. Momin,et al.  A Comprehensive Review on Dry Eye Disease: Diagnosis, Medical Management, Recent Developments, and Future Challenges , 2015 .

[11]  H. Ullum,et al.  Ready‐made allogeneic ABO‐specific serum eye drops: production from regular male blood donors, clinical routine, safety and efficacy , 2014, Acta ophthalmologica.

[12]  Roni M. Shtein,et al.  Long-term Use of Autologous Serum 50% Eye Drops for the Treatment of Dry Eye Disease , 2014, Cornea.

[13]  T. Kim,et al.  Proposal of standardized guidelines for the production and quality control of autologous serum eye drops in Korea: based on a nationwide survey , 2014, Transfusion.

[14]  E. Akpek,et al.  Dry Eye: an Inflammatory Ocular Disease , 2014, Journal of ophthalmic & vision research.

[15]  A. Celebi,et al.  The efficacy of autologous serum eye drops for severe dry eye syndrome: a randomized double-blind crossover study , 2014, Graefe's Archive for Clinical and Experimental Ophthalmology.

[16]  K. Jirsova,et al.  The Application of Autologous Serum Eye Drops in Severe Dry Eye Patients; Subjective and Objective Parameters Before and After Treatment , 2014, Current eye research.

[17]  J. S. López-García,et al.  Use of containers with sterilizing filter in autologous serum eyedrops. , 2012, Ophthalmology.

[18]  J. Y. Ku,et al.  Topical fresh frozen plasma and heparin treatment of ligneous conjunctivitis in a Canadian hospital setting. , 2012, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie.

[19]  M. Kim,et al.  Allogeneic serum eye drops for the treatment of dry eye patients with chronic graft-versus-host disease. , 2012, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[20]  H. Platokouki,et al.  Management of ligneous conjunctivitis in a child with plasminogen deficiency , 2011, European Journal of Pediatrics.

[21]  Sandra M. Brown,et al.  Time- and Temperature-Dependent Stability of Growth Factor Peptides in Human Autologous Serum Eye Drops , 2009, Cornea.

[22]  J. Bradley,et al.  Serum growth factor analysis in dry eye syndrome , 2008, Clinical & experimental ophthalmology.

[23]  A. Shapiro,et al.  Plasminogen deficiency , 2008, Haemophilia : the official journal of the World Federation of Hemophilia.

[24]  G. Vogelsang,et al.  Chronic graft versus host disease , 2004, British journal of haematology.

[25]  T. Nishida,et al.  Correlation of proliferative and anti-apoptotic effects of HGF, insulin, IGF-1, IGF-2, and EGF in SV40-transformed human corneal epithelial cells. , 2006, Experimental eye research.

[26]  K. Tsubota,et al.  The effect of autologous serum eyedrops in the treatment of severe dry eye disease: a prospective randomized case-control study. , 2005, American journal of ophthalmology.

[27]  K. Pesudovs,et al.  Comparison of autologous serum eye drops with conventional therapy in a randomised controlled crossover trial for ocular surface disease , 2004, British Journal of Ophthalmology.

[28]  K. Tsubota,et al.  Treatment of dry eye by autologous serum application in Sjögren’s syndrome , 1999 .

[29]  K. Tsubota,et al.  Treatment of dry eye by autologous serum application in Sjögren’s syndrome , 1998, The British journal of ophthalmology.

[30]  B. Mclaughlin,et al.  Is another mannose receptor-like lectin present in retinal pigment epithelium? , 1999, Current Eye Research.

[31]  Napier.  Guide to the Preparation, Use and Quality Assurance of Blood Components. , 1998 .

[32]  G. Seong,et al.  TGF-beta s stimulate cell proliferation via an autocrine production of FGF-2 in corneal stromal fibroblasts. , 1998, Current eye research.

[33]  K. Tadokoro,et al.  Activation of the contact system by filtration of platelet concentrates with a negatively charged white cell‐removal filter and measurement of venous blood bradykinin level in patients who received filtered platelets , 1997, Transfusion.

[34]  R. Davenport,et al.  Removal of soluble biologic response modifiers (complement and chemokines) by a bedside white cell‐reduction filter , 1996, Transfusion.

[35]  T. Kamiya,et al.  Adsorption of Anaphylatoxins and Platelet‐Specific Proteins by Filtration of Platelet Concentrates with a Polyester Leukocyte Reduction Filter , 1994, Vox sanguinis.

[36]  J. Belmont,et al.  Beneficial effect of artificial tears made with autologous serum in patients with keratoconjunctivitis sicca. , 1984, Arthritis and rheumatism.