Ulcerative Infiltrated Plaques in a Bolivian Boy

Case Report A5-year-oldboy fromBoliviawhohadarrived inSpain only 15 days previouslywas referred to our department with a 3-week history of worsening cutaneous lesions. The lesions started with erythema and induration, and gradually progressed to become ulcerative plaques localized on his right leg, lumbar region, right temple, and right eyebrow. All lesions were asymptomatic and the patient was afebrile. Examination of the lumbar region demonstrated a 5 cm erythematous, indurated plaque containing small punched-out ulcers with a yellow base. A similar, smaller lesion was nearby. On the right leg he had a large indurated plaque with extensive ulceration (Fig. 1). Similar plaques on the right temple and right eyebrow had superficial yellow crusting. Examination of the oral cavity revealed black tooth remnants, and two yellow papules on the upper gingiva (Fig. 2). Lymphadenopathy was found in the right groin. Ear, nose, and throat examinations showed no abnormality. Complete blood count, liver function tests, glucose, urea, creatinine, lipoproteins, and protein electrophoresis were within normal range. Chest radiograph was unremarkable. Mantoux skin test, leishmania serology, and cultures from surface swabs formycobacteria and leishmaniawere all negative. Skin biopsy was performed. On the basis of the findings (Fig. 3) further investigations were undertaken.

[1]  C. Gillberg,et al.  Oculo‐auriculo‐vertebral spectrum: Associated anomalies, functional deficits and possible developmental risk factors , 2007, American journal of medical genetics. Part A.

[2]  D. Wieczorek,et al.  A family with autosomal dominant oculo-auriculo-vertebral spectrum , 2007, Clinical dysmorphology.

[3]  Eli Schwartz,et al.  New world cutaneous leishmaniasis in travellers. , 2006, The Lancet. Infectious diseases.

[4]  J. Soto,et al.  Miltefosine: oral treatment of leishmaniasis , 2006, Expert review of anti-infective therapy.

[5]  C. Jaffe,et al.  Comparison of PCR Assays for Diagnosis of Cutaneous Leishmaniasis , 2006, Journal of Clinical Microbiology.

[6]  D. David,et al.  Spinal Anomalies in Goldenhar Syndrome , 2005, The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.

[7]  C. Bodemer,et al.  Skin markers of occult spinal dysraphism in children: a review of 54 cases. , 2004, Archives of dermatology.

[8]  D. Metry,et al.  Multiple accessory tragi as a clue to the diagnosis of the oculo-auriculo-vertebral (Goldenhar) syndrome. , 2004, Journal of the American Academy of Dermatology.

[9]  P. Desjeux,et al.  Treatment of cutaneous leishmaniasis among travellers. , 2004, The Journal of antimicrobial chemotherapy.

[10]  L D Edmonds,et al.  Goldenhar syndrome among infants born in military hospitals to Gulf War veterans. , 1997, Teratology.

[11]  C. Tifft,et al.  Neurodevelopmental profile of infants and toddlers with oculo-auriculo-vertebral spectrum and the correlation of prognosis with physical findings. , 1995, American journal of medical genetics.

[12]  L. Clowry,et al.  The hair collar sign: marker for cranial dysraphism. , 1995, Pediatrics.

[13]  Anil Kumar,et al.  Pattern of cardiac malformation in oculoauriculovertebral spectrum. , 1993, American journal of medical genetics.

[14]  M. Rogers,et al.  Heterotropic brain tissue presenting as bald cysts with a collar of hypertrophic hair. The 'hair collar' sign. , 1989, Archives of dermatology.

[15]  E. Kanavakis,et al.  Clinical manifestations in 17 Greek patients with Goldenhar syndrome. , 2006, Genetic counseling.

[16]  S. Croft,et al.  Chemotherapy in the treatment and control of leishmaniasis. , 2006, Advances in parasitology.

[17]  Arfan ul Bari,et al.  Correlation of clinical, histopathological, and microbiological findings in 60 cases of cutaneous leishmaniasis. , 2006, Indian journal of dermatology, venereology and leprology.