Beta activity in the subthalamic nucleus during sleep in patients with Parkinson's disease

The recordings of local field potentials in the subthalamic nucleus in patients with Parkinson's disease (PD), carried out through the stimulators implanted to treat the motor symptoms of the disease, show a prominent basal (“off”) activity in the beta range, which is attenuated after dopaminergic therapy. A recent study described improvement of parkinsonian features during rapid eyes movements (REM) sleep. We describe, for the first time, the changes in activity of the subthlamic nucleus (STN) during different sleep stages in Parkinson's disease with special interest in the beta band. Ten patients with PD treated with deep brain stimulation of the STN were studied. Subthalamic local field potentials (LFPs) were recorded through the stimulation electrodes during wakefulness (“off” medication) and different sleep stages. In Stage 2 and slow‐wave sleep, a significant decrease of beta activity was recorded. During REM sleep, beta power values were similar to wakefulness values or even higher. These findings indicate that STN activity is modulated and modified during different sleep stages. The increased beta activity during REM sleep is a new but unexpected finding, which requires further analysis. © 2008 Movement Disorder Society

[1]  S Cerutti,et al.  300-Hz subthalamic oscillations in Parkinson's disease. , 2003, Brain : a journal of neurology.

[2]  F. Grandas,et al.  Nocturnal problems occurring in Parkinson’s disease , 2004, Neurology.

[3]  M W Mahowald,et al.  Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. , 2007, Brain : a journal of neurology.

[4]  E. Wolpert.  A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. , 1969 .

[5]  J. Dostrovsky,et al.  Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease. , 2006, Journal of neurophysiology.

[6]  R. Lesser,et al.  Functional mapping of human sensorimotor cortex with electrocorticographic spectral analysis. I. Alpha and beta event-related desynchronization. , 1998, Brain : a journal of neurology.

[7]  A. Priori,et al.  Movement-related modulation of neural activity in human basal ganglia and its L-DOPA dependency: recordings from deep brain stimulation electrodes in patients with Parkinson's disease , 2002, Neurological Sciences.

[8]  J A Obeso,et al.  Movement‐related changes in oscillatory activity in the human subthalamic nucleus: ipsilateral vs. contralateral movements , 2005, The European journal of neuroscience.

[9]  T. Gasser,et al.  Transformations towards the normal distribution of broad band spectral parameters of the EEG. , 1982, Electroencephalography and clinical neurophysiology.

[10]  Vladimir Litvak,et al.  Excessive synchronization of basal ganglia neurons at 20 Hz slows movement in Parkinson's disease , 2007, Experimental Neurology.

[11]  J. Artieda,et al.  Movement-related changes in cortical oscillatory activity in ballistic, sustained and negative movements , 2002, Experimental Brain Research.

[12]  G. Bernardi,et al.  Spontaneous sleep modulates the firing pattern of Parkinsonian subthalamic nucleus , 2005, Experimental Brain Research.

[13]  B. Jacobs,et al.  Behavioral correlates of dopaminergic unit activity in freely moving cats , 1983, Brain Research.

[14]  Emmanuel Roze,et al.  Restoration of normal motor control in Parkinson's disease during REM sleep. , 2007, Brain : a journal of neurology.

[15]  A. Lozano,et al.  Targeting the basal ganglia for deep brain stimulation in Parkinson's disease. , 2000, Neurology.

[16]  R. D. Nass,et al.  ACTIGRAPHIC EVIDENCE FOR NIGHT-TIME HYPERKINESIA IN PARKINSON’S DISEASE , 2008, The International journal of neuroscience.

[17]  P. Brown.  Oscillatory nature of human basal ganglia activity: Relationship to the pathophysiology of Parkinson's disease , 2003, Movement disorders : official journal of the Movement Disorder Society.

[18]  A. Oliviero,et al.  Dopamine Dependency of Oscillations between Subthalamic Nucleus and Pallidum in Parkinson's Disease , 2001, The Journal of Neuroscience.

[19]  P. Brown,et al.  Levodopa‐induced modulation of subthalamic beta oscillations during self‐paced movements in patients with Parkinson's disease , 2005, The European journal of neuroscience.

[20]  P. Brown,et al.  Reduction in subthalamic 8–35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease , 2006, The European journal of neuroscience.

[21]  D. German,et al.  Activity of mesencephalic dopamine and non-dopamine neurons across stages of sleep and waking in the rat , 1983, Brain Research.

[22]  H. Bergman,et al.  Pathological synchronization in Parkinson's disease: networks, models and treatments , 2007, Trends in Neurosciences.

[23]  A. Priori,et al.  Rhythm-specific pharmacological modulation of subthalamic activity in Parkinson's disease , 2004, Experimental Neurology.

[24]  J A Obeso,et al.  Slow oscillatory activity and levodopa-induced dyskinesias in Parkinson's disease. , 2006, Brain : a journal of neurology.

[25]  K. Mewes,et al.  The subthalamic nucleus in Parkinson's disease: somatotopic organization and physiological characteristics. , 2001, Brain : a journal of neurology.

[26]  A. Oliviero,et al.  Dopamine-dependent changes in the functional connectivity between basal ganglia and cerebral cortex in humans. , 2002, Brain : a journal of neurology.