High prevalence of relapse in children with Philadelphia-like acute lymphoblastic leukemia despite risk-adapted treatment

Acute lymphoblastic leukemia (ALL) remains a leading cause of cancer-related death in children and young adults. Since the 1960s, improvements in the treatment of children with ALL have led to 10-year survival rates now exceeding 85%.[1][1] Philadelphia-like (Ph-like) ALL is characterized by a gene

[1]  M. Loh,et al.  Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group. , 2017, Blood.

[2]  C. Bloomfield,et al.  High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults. , 2017, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[3]  M. D. Den Boer,et al.  Tyrosine kinase fusion genes in pediatric BCR-ABL1-like acute lymphoblastic leukemia , 2016, Oncotarget.

[4]  W. Evans,et al.  BCR-ABL1-like cases in pediatric acute lymphoblastic leukemia: a comparison between DCOG/Erasmus MC and COG/St. Jude signatures , 2015, Haematologica.

[5]  T. Révész,et al.  Persistent MRD before and after allogeneic BMT predicts relapse in children with acute lymphoblastic leukaemia , 2015, British journal of haematology.

[6]  O. Kallioniemi,et al.  FusionCatcher – a tool for finding somatic fusion genes in paired-end RNA-sequencing data , 2014, bioRxiv.

[7]  J. Downing,et al.  Outcomes of children with BCR-ABL1–like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[8]  Heather L. Mulder,et al.  Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. , 2014, The New England journal of medicine.

[9]  J. Downing,et al.  A Revised Definition for Cure of Childhood Acute Lymphoblastic Leukemia , 2014, Leukemia.

[10]  Michael C. Rusch,et al.  Development and Validation Of a Highly Sensitive and Specific Gene Expression Classifier To Prospectively Screen and Identify B-Precursor Acute Lymphoblastic Leukemia (ALL) Patients With a Philadelphia Chromosome-Like (“Ph-like” or “BCR-ABL1-Like”) Signature For Therapeutic Targeting and Clinical In , 2013 .

[11]  Daniel Catchpoole,et al.  Improving the Identification of High Risk Precursor B Acute Lymphoblastic Leukemia Patients with Earlier Quantification of Minimal Residual Disease , 2013, PloS one.

[12]  W. Evans,et al.  Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL. , 2013, Blood.

[13]  Jin Billy Li,et al.  Reliable identification of genomic variants from RNA-seq data. , 2013, American journal of human genetics.

[14]  R. Pieters,et al.  High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation , 2013, Leukemia.

[15]  Ryan D. Morin,et al.  Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia. , 2012, Cancer cell.

[16]  Süleyman Cenk Sahinalp,et al.  deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data , 2011, PLoS Comput. Biol..

[17]  J. Downing,et al.  Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia. , 2010, Blood.

[18]  Heidi Dvinge,et al.  HTqPCR: high-throughput analysis and visualization of quantitative real-time PCR data in R , 2009, Bioinform..

[19]  W. Evans,et al.  A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. , 2009, The Lancet. Oncology.

[20]  Christopher B. Miller,et al.  Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. , 2009, The New England journal of medicine.

[21]  J. Cayuela,et al.  Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data , 2007, Leukemia.

[22]  R. Tibshirani,et al.  Diagnosis of multiple cancer types by shrunken centroids of gene expression , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[23]  W. Evans,et al.  BCR-ABL 1-like cases in pediatric acute lymphoblastic leukemia : a comparison between DCOG / Erasmus MC and COG / St , 2015 .

[24]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[25]  C. Pratt,et al.  St. Jude Children's Research Hospital. , 1997, Pediatric hematology and oncology.