Involvement of Mast Cells in α7 Nicotinic Receptor Agonist Exacerbation of Freund's Complete Adjuvant–Induced Monoarthritis in Mice

Activation of antiinflammatory cholinergic (vagal) pathways can reduce inflammation, and in vitro studies support a pivotal role of α7 nicotinic acetylcholine receptors (α7‐nAChR), macrophages, and T cells in these events. The aim of this study was to assess α7‐nAChR agonists as an antiinflammatory treatment for Freund's complete adjuvant (CFA)–induced monoarthritis.

[1]  C. González-Espinosa,et al.  Stimulation of nAchRα7 Receptor Inhibits TNF Synthesis and Secretion in Response to LPS Treatment of Mast Cells by Targeting ERK1/2 and TACE Activation , 2018, Journal of Neuroimmune Pharmacology.

[2]  S. McMahon,et al.  Peripheral inflammatory pain sensitisation is independent of mast cell activation in male mice , 2017, Pain.

[3]  O. Silvennoinen,et al.  The activity of JAK-STAT pathways in rheumatoid arthritis: constitutive activation of STAT3 correlates with interleukin 6 levels. , 2015, Rheumatology.

[4]  J. Tuckermann,et al.  Mast Cell Promotion of T Cell–Driven Antigen‐Induced Arthritis Despite Being Dispensable for Antibody‐Induced Arthritis in Which T Cells Are Bypassed , 2015, Arthritis & rheumatology.

[5]  M. Colombo,et al.  Mast Cells Control the Expansion and Differentiation of IL-10–Competent B Cells , 2014, Journal of Immunology.

[6]  M. Neuman,et al.  Safety of anti-tumor necrosis factor therapies in arthritis patients. , 2014, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[7]  Xianzhong Xiao,et al.  Attenuation of collagen induced arthritis via suppression on Th17 response by activating cholinergic anti-inflammatory pathway with nicotine. , 2014, European journal of pharmacology.

[8]  C. Serhan,et al.  Vagus nerve controls resolution and pro-resolving mediators of inflammation , 2014, The Journal of experimental medicine.

[9]  Sun-Mee Lee,et al.  Stimulation of the α7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation. , 2014, The Journal of infectious diseases.

[10]  K. Sunagawa,et al.  Stimulation of α7 nicotinic acetylcholine receptor by AR-R17779 suppresses atherosclerosis and aortic aneurysm formation in apolipoprotein E-deficient mice. , 2014, Vascular pharmacology.

[11]  T. Mak,et al.  Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex , 2014, Nature Medicine.

[12]  M. Mckinley,et al.  Reflex control of inflammation by sympathetic nerves, not the vagus , 2014, The Journal of physiology.

[13]  M. Kadowaki,et al.  Anti-Allergic Role of Cholinergic Neuronal Pathway via α7 Nicotinic ACh Receptors on Mucosal Mast Cells in a Murine Food Allergy Model , 2014, PloS one.

[14]  G. Boeckxstaens,et al.  Nicotine Attenuates Activation of Tissue Resident Macrophages in the Mouse Stomach through the β2 Nicotinic Acetylcholine Receptor , 2013, PloS one.

[15]  K. Tracey,et al.  A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen , 2013, Gut.

[16]  V. Pavlov,et al.  Central cholinergic activation of a vagus nerve - to spleen circuit alleviates experimental colitis , 2013, Mucosal Immunology.

[17]  J. McDougall,et al.  Murine autoimmune arthritis is exaggerated by infection with the rat tapeworm, Hymenolepis diminuta. , 2013, International journal for parasitology.

[18]  W. D. de Jonge,et al.  The Gut's Little Brain in Control of Intestinal Immunity , 2013, ISRN gastroenterology.

[19]  De Jonge,et al.  The Gut's Little Brain in Control of Intestinal Immunity. , 2013 .

[20]  Bernadette A. Thomas,et al.  Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.

[21]  R. Edwards,et al.  Cytokine-Induced Alterations of α7 Nicotinic Receptor in Colonic CD4 T Cells Mediate Dichotomous Response to Nicotine in Murine Models of Th1/Th17- versus Th2-Mediated Colitis , 2011, The Journal of Immunology.

[22]  M. Teixeira,et al.  Resolution of neutrophilic inflammation by H2O2 in antigen-induced arthritis. , 2011, Arthritis and rheumatism.

[23]  S. Verstappen,et al.  What is the outcome of RA in 2011 and can we predict it? , 2011, Best practice & research. Clinical rheumatology.

[24]  Hyo Jeong Kim,et al.  Tristetraprolin Mediates Anti-inflammatory Effects of Nicotine in Lipopolysaccharide-stimulated Macrophages* , 2011, The Journal of Biological Chemistry.

[25]  Jae Heun Lee,et al.  Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine attenuates inflammatory response in macrophages and improves survival in experimental model of sepsis through heme oxygenase-1 induction. , 2011, Antioxidants & redox signaling.

[26]  S. Bevan,et al.  A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis. , 2011, Arthritis and rheumatism.

[27]  K. Kuča,et al.  Macrophage-assisted inflammation and pharmacological regulation of the cholinergic anti-inflammatory pathway. , 2011, Current medicinal chemistry.

[28]  A. Ogata,et al.  Tocilizumab for the treatment of rheumatoid arthritis , 2010, Expert review of clinical immunology.

[29]  P. Tak,et al.  Role of the cholinergic nervous system in rheumatoid arthritis: aggravation of arthritis in nicotinic acetylcholine receptor α7 subunit gene knockout mice , 2010, Annals of the rheumatic diseases.

[30]  E. P. van der Zanden,et al.  Selective α7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis , 2010, British journal of pharmacology.

[31]  Xianzhong Xiao,et al.  The Vagus Nerve and Nicotinic Receptors Involve Inhibition of HMGB1 Release and Early Pro-inflammatory Cytokines Function in Collagen-Induced Arthritis , 2010, Journal of Clinical Immunology.

[32]  K. Hashimoto,et al.  In Vivo Evaluation of α7 Nicotinic Acetylcholine Receptor Agonists [11C]A-582941 and [11C]A-844606 in Mice and Conscious Monkeys , 2010, PloS one.

[33]  C. Chen,et al.  Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice. , 2010, The American journal of pathology.

[34]  A. Orr-Urtreger,et al.  Activation of the Cholinergic Anti-Inflammatory System by Nicotine Attenuates Neuroinflammation via Suppression of Th1 and Th17 Responses , 2009, The Journal of Immunology.

[35]  J. Waring,et al.  Role of α7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-α (TNF-α) as revealed by subtype selective agonists , 2009, Journal of Neuroimmunology.

[36]  E. P. van der Zanden,et al.  agus Nerve Activity Augments Intestinal Macrophage Phagocytosis via icotinic Acetylcholine Receptor 4 2 , 2022 .

[37]  K. Tracey,et al.  The Selective α7 Agonist GTS-21 Attenuates Cytokine Production in Human Whole Blood and Human Monocytes Activated by Ligands for TLR2, TLR3, TLR4, TLR9, and RAGE , 2009, Molecular medicine.

[38]  M. Åbrink,et al.  Mast cell chymase contributes to the antibody response and the severity of autoimmune arthritis , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[39]  Natsuko Kageyama-Yahara,et al.  IgE-induced degranulation of mucosal mast cells is negatively regulated via nicotinic acetylcholine receptors. , 2008, Biochemical and biophysical research communications.

[40]  V. Pavlov,et al.  Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor. , 2008, Arthritis and rheumatism.

[41]  J. McDougall,et al.  Leukocyte trafficking and pain behavioral responses to a hydrogen sulfide donor in acute monoarthritis. , 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

[42]  F. Castellino,et al.  N-methyl-d-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein , 2008, Neuropharmacology.

[43]  Valentin A. Pavlov,et al.  Modulation of TNF Release by Choline Requires α7 Subunit Nicotinic Acetylcholine Receptor-Mediated Signaling , 2008, Molecular medicine.

[44]  V. Pavlov,et al.  Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis * , 2007, Critical care medicine.

[45]  T. van der Poll,et al.  LOCAL STIMULATION OF α7 CHOLINERGIC RECEPTORS INHIBITS LPS-INDUCED TNF-α RELEASE IN THE MOUSE LUNG , 2007, Shock.

[46]  E. Brodin,et al.  Spontaneous nociceptive behaviour in female mice with Freund's complete adjuvant- and carrageenan-induced monoarthritis , 2007, Brain Research.

[47]  T. van der Poll,et al.  STIMULATION OF &agr;7 CHOLINERGIC RECEPTORS INHIBITS LIPOPOLYSACCHARIDE-INDUCED NEUTROPHIL RECRUITMENT BY A TUMOR NECROSIS FACTOR &agr;-INDEPENDENT MECHANISM , 2007, Shock.

[48]  F. Cunha,et al.  Hypernociception elicited by tibio-tarsal joint flexion in mice: A novel experimental arthritis model for pharmacological screening , 2006, Pharmacology Biochemistry and Behavior.

[49]  A. Yoshimura,et al.  The neuropeptide neuromedin U promotes inflammation by direct activation of mast cells , 2005, The Journal of experimental medicine.

[50]  A. Orr-Urtreger,et al.  Increased severity of experimental colitis in alpha5 nicotinic acetylcholine receptor subunit-deficient mice , 2005, Neuroreport.

[51]  K. Tracey,et al.  Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis , 2004, Nature Medicine.

[52]  F. Cunha,et al.  An electronic pressure-meter nociception paw test for rats. , 2004, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[53]  L. Donaldson,et al.  Characterisation of a Freund's complete adjuvant-induced model of chronic arthritis in mice , 2003, Journal of Neuroscience Methods.

[54]  Kevin J. Tracey,et al.  Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation , 2002, Nature.

[55]  R. Teshima,et al.  Nerve-mast cell (RBL) interaction: RBL membrane ruffling occurs at the contact site with an activated neurite. , 2002, American journal of physiology. Cell physiology.

[56]  G. Panagis,et al.  Effects of methyllycaconitine (MLA), an α7 nicotinic receptor antagonist, on nicotine- and cocaine-induced potentiation of brain stimulation reward , 2000, Psychopharmacology.

[57]  J. McDougall,et al.  Cholinergic vasoregulation in normal and adjuvant monoarthritic rat knee joints. , 1998, Journal of the autonomic nervous system.

[58]  R. Stead,et al.  Effect of truncal vagotomy and capsaicin on mast cells and IgA‐positive plasma cells in rat jejunal mucosa , 1997, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[59]  F. Levi-Schaffer,et al.  Mast cell activity in experimental allergic encephalomyelitis. , 1991, Molecular and chemical neuropathology.

[60]  T. Frieling,et al.  Synaptic transmission in submucosal ganglia of guinea pig distal colon. , 1991, The American journal of physiology.

[61]  T. Poll,et al.  STIMULATION OF ! 7 CHOLINERGIC RECEPTORS INHIBITS LIPOPOLYSACCHARIDE-INDUCED NEUTROPHIL RECRUITMENT BY A TUMOR NECROSIS FACTOR ! Y INDEPENDENT MECHANISM , 2018 .

[62]  A. Ogata,et al.  Targeting of Interleukin-6 for the Treatment of Rheumatoid Arthritis: A Review and Update , 2014 .

[63]  B. Bonaz,et al.  Brain-gut interactions in inflammatory bowel disease. , 2013, Gastroenterology.

[64]  Y. Okayama,et al.  Activation of human synovial mast cells from rheumatoid arthritis or osteoarthritis patients in response to aggregated IgG through Fcγ receptor I and Fcγ receptor II. , 2013, Arthritis and rheumatism.

[65]  T. van der Poll,et al.  Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice. , 2009, Arthritis and rheumatism.

[66]  E. Sternberg,et al.  Neuroendocrine factors alter host defense by modulating immune function. , 2008, Cellular immunology.

[67]  F. Cunha,et al.  An electronic pressure-meter nociception paw test for mice. , 2004, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.