What makes a champion? Explaining variation in human athletic performance

[1]  E. Barrey,et al.  Heritability of percentage of fast myosin heavy chains in skeletal muscles and relationship with performance. , 2010, Equine veterinary journal. Supplement.

[2]  G. Beunen,et al.  Quantitative trait loci for human muscle strength: linkage analysis of myostatin pathway genes. , 2005, Physiological genomics.

[3]  Elizabeth L. Ogburn,et al.  Demonstrating stratification in a European American population , 2005, Nature Genetics.

[4]  D. MacArthur,et al.  Genes and human elite athletic performance , 2005, Human Genetics.

[5]  Imran Y. Khan,et al.  Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals? , 2004, The Journal of physiology.

[6]  J. Kere,et al.  The effects of the ACE gene insertion/deletion polymorphism on glucose tolerance and insulin secretion in elderly people are modified by birth weight. , 2004, The Journal of clinical endocrinology and metabolism.

[7]  G. Beunen,et al.  Gene Powered? Where to Go from Heritability (h2) in Muscle Strength and Power? , 2004, Exercise and sport sciences reviews.

[8]  Guoyao Wu,et al.  Maternal nutrition and fetal development. , 2004, The Journal of nutrition.

[9]  Rachael W Taylor,et al.  Rate of fat gain is faster in girls undergoing early adiposity rebound. , 2004, Obesity research.

[10]  M. Bray,et al.  Gene-nutrition interaction in human performance and exercise response. , 2004, Nutrition.

[11]  J. González-Barranco,et al.  Early malnutrition and metabolic abnormalities later in life. , 2004, Nutrition reviews.

[12]  G. Beunen,et al.  Linkage of myostatin pathway genes with knee strength in humans. , 2004, Physiological genomics.

[13]  M. Daly,et al.  Methods for high-density admixture mapping of disease genes. , 2004, American journal of human genetics.

[14]  C. Hoggart,et al.  Design and analysis of admixture mapping studies. , 2004, American journal of human genetics.

[15]  C. Bouchard,et al.  Exploration of myostatin polymorphisms and the angiotensin-converting enzyme insertion/deletion genotype in responses of human muscle to strength training , 2004, European Journal of Applied Physiology.

[16]  N. Geladas,et al.  Heritability in neuromuscular coordination: implications for motor control strategies. , 2004, Medicine and science in sports and exercise.

[17]  C. Bouchard,et al.  Quantitative trait loci for maximal exercise capacity phenotypes and their responses to training in the HERITAGE Family Study. , 2004, Physiological genomics.

[18]  C. Bouchard,et al.  Titin is a candidate gene for stroke volume response to endurance training: the HERITAGE Family Study , 2003 .

[19]  K. Myburgh.  What makes an endurance athlete world-class? Not simply a physiological conundrum. , 2003, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[20]  J. Rupert.  The search for genotypes that underlie human performance phenotypes. , 2003, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[21]  C. Bouchard,et al.  Genome-wide linkage scan for physical activity levels in the Quebec Family study. , 2003, Medicine and science in sports and exercise.

[22]  C. Bouchard,et al.  The human gene map for performance and health-related fitness phenotypes: the 2005 update. , 2003 .

[23]  C. Bouchard,et al.  A quantitative trait locus on 7q31 for the changes in plasma insulin in response to exercise training: the HERITAGE Family Study. , 2003, Diabetes.

[24]  C. Bouchard,et al.  Titin is a candidate gene for stroke volume response to endurance training: the HERITAGE Family Study. , 2003, Physiological genomics.

[25]  J. Barrett,et al.  Heritability of features of the insulin resistance syndrome in a community‐based study of healthy families , 2002, Diabetic medicine : a journal of the British Diabetic Association.

[26]  N. Cameron,et al.  Critical periods in human growth and their relationship to diseases of aging. , 2002, American journal of physical anthropology.

[27]  C. Cooper,et al.  Polymorphism of the IGF2 gene, birth weight and grip strength in adult men. , 2002, Age and ageing.

[28]  Kei-Hoi Cheung,et al.  ALFRED: An allele frequency database for anthropology. , 2002, American journal of physical anthropology.

[29]  C. Bouchard,et al.  Genome-wide linkage scan for exercise stroke volume and cardiac output in the HERITAGE Family Study. , 2002, Physiological genomics.

[30]  G. Wolff,et al.  Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring. , 2002, The Journal of nutrition.

[31]  D. Patel,et al.  Genes and athletes. , 2002, Adolescent Medicine.

[32]  John Kwagyan,et al.  CYP3A4-V and prostate cancer in African Americans: causal or confounding association because of population stratification? , 2002, Human Genetics.

[33]  G. Beunen,et al.  Birth weight and body composition in young women: a prospective twin study. , 2002, The American journal of clinical nutrition.

[34]  N. Martin,et al.  Heritabilities of apolipoprotein and lipid levels in three countries. , 2002, Twin research : the official journal of the International Society for Twin Studies.

[35]  C. Bouchard,et al.  Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE study. , 2002, Journal of applied physiology.

[36]  Andrea F. Huberty,et al.  ACE insertion/deletion polymorphism and submaximal exercise hemodynamics in postmenopausal women. , 2002, Journal of applied physiology.

[37]  C. Bouchard,et al.  A genomewide linkage scan for abdominal subcutaneous and visceral fat in black and white families: The HERITAGE Family Study. , 2002, Diabetes.

[38]  N. Dickson,et al.  Early growth, menarche, and adiposity rebound , 2002, The Lancet.

[39]  C. Bouchard,et al.  Familial resemblance in ventilatory threshold: the HERITAGE Family Study. , 2001, Medicine and science in sports and exercise.

[40]  G. Beunen,et al.  Birth weight and body composition in young adult men—a prospective twin study , 2001, International Journal of Obesity.

[41]  C. Maltin,et al.  Impact of manipulations of myogenesis in utero on the performance of adult skeletal muscle. , 2001, Reproduction.

[42]  C. Bouchard,et al.  Familial resemblance for free androgens and androgen glucuronides in sedentary black and white individuals: the HERITAGE Family Study. Health, Risk Factors, Exercise Training and Genetics. , 2001, The Journal of endocrinology.

[43]  T. Rice,et al.  Race differences in the pattern of familial aggregation for dehydroepiandrosterone sulfate and its responsiveness to training in the HERITAGE Family Study. , 2001, Metabolism: clinical and experimental.

[44]  C. Bouchard,et al.  Genomic Scan for Exercise Blood Pressure in the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study , 2001, Hypertension.

[45]  C. Bouchard,et al.  The human gene map for performance and health-related fitness phenotypes. , 2001, Medicine and science in sports and exercise.

[46]  Y. Chagnon,et al.  Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE. , 2001, Journal of applied physiology.

[47]  A. Petronis,et al.  Human morbid genetics revisited: relevance of epigenetics. , 2001, Trends in genetics : TIG.

[48]  Timothy B. Stockwell,et al.  The Sequence of the Human Genome , 2001, Science.

[49]  J. V. Moran,et al.  Initial sequencing and analysis of the human genome. , 2001, Nature.

[50]  R M Malina,et al.  Physical activity and fitness: Pathways from childhood to adulthood , 2001, American journal of human biology : the official journal of the Human Biology Council.

[51]  R. Noll.  It's Not About the Bike: My Journey Back to Life. , 2000 .

[52]  C. Bouchard,et al.  Genome-Wide Linkage Analysis of Systolic and Diastolic Blood Pressure: The Québec Family Study , 2000, Circulation.

[53]  C. Fischer,et al.  Abnormal Pulmonary Artery Pressure Response in Asymptomatic Carriers of Primary Pulmonary Hypertension Gene , 2000, Circulation.

[54]  T. Rice,et al.  A genetic study of sex hormone--binding globulin measured before and after a 20-week endurance exercise training program: the HERITAGE Family Study. , 2000, Metabolism: clinical and experimental.

[55]  N. Ahuja,et al.  Aging, methylation and cancer. , 2000, Histology and histopathology.

[56]  N. Risch.  Searching for genetic determinants in the new millennium , 2000, Nature.

[57]  C. Bouchard,et al.  Tracking of familial resemblance for resting blood pressure over time in the Québec Family Study. , 2000, Human Biology: The Official Publication of the American Association of Anthropological Genetics.

[58]  D. Williamson,et al.  Relation of birth weight to lean and fat thigh tissue in young men , 2000, International Journal of Obesity.

[59]  C. Bouchard,et al.  Familial resemblance in fatness and fat distribution , 2000, American journal of human biology : the official journal of the Human Biology Council.

[60]  J. Carpenter,et al.  Estimation of admixture and detection of linkage in admixed populations by a Bayesian approach: application to African‐American populations , 2000, Annals of human genetics.

[61]  C. Bouchard,et al.  Genomic scan for maximal oxygen uptake and its response to training in the HERITAGE Family Study. , 2000, Journal of applied physiology.

[62]  W. Ewens.  Genetics and analysis of quantitative traits , 1999 .

[63]  Y. Chagnon,et al.  Association and linkage between an insulin-like growth FACTOR-1 GENE polymorphism and fat free mass in the HERITAGE Family Study , 1999, International Journal of Obesity.

[64]  C. Bouchard,et al.  Familial aggregation of VO(2max) response to exercise training: results from the HERITAGE Family Study. , 1999, Journal of applied physiology.

[65]  J. Connell,et al.  Angiotensin‐converting enzyme gene and diabetes mellitus , 1999, Diabetic medicine : a journal of the British Diabetic Association.

[66]  R. Lyle,et al.  Previous milk consumption is associated with greater bone density in young women. , 1999, The American journal of clinical nutrition.

[67]  B. Ponder,et al.  Accumulation of p53 protein is frequent in ovarian cancers associated with BRCA1 and BRCA2 germline mutations. , 1999, Journal of clinical pathology.

[68]  C. Bouchard,et al.  Linkage between a muscle-specific CK gene marker and VO2max in the HERITAGE Family Study. , 1999, Medicine and science in sports and exercise.

[69]  K. Weiss,et al.  Linkage disequilibrium mapping of complex disease: fantasy or reality? , 1998, Current opinion in biotechnology.

[70]  J. Després,et al.  Familial clustering of insulin and abdominal visceral fat: the HERITAGE Family Study. , 1998, The Journal of clinical endocrinology and metabolism.

[71]  P. McKeigue,et al.  Mapping genes that underlie ethnic differences in disease risk: methods for detecting linkage in admixed populations, by conditioning on parental admixture. , 1998, American journal of human genetics.

[72]  Ian N. M. Day,et al.  Molecules in focus Insulin-like growth factor II (IGF-II) , 1998 .

[73]  F. Rasmussen,et al.  The relation of weight, length and ponderal index at birth to body mass index and overweight among 18-year-old males in Sweden , 1998, European Journal of Epidemiology.

[74]  E. Garrido,et al.  Heritability of running economy: a study made on twin brothers , 1998, European Journal of Applied Physiology and Occupational Physiology.

[75]  J H Wilmore,et al.  Familial resemblance for VO2max in the sedentary state: the HERITAGE family study. , 1998, Medicine and science in sports and exercise.

[76]  T. Spector,et al.  Genetic Influences on Muscle Strength, Lean Body Mass, and Bone Mineral Density: A Twin Study , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[77]  C. Bouchard,et al.  Familial resemblance for body composition measures: the HERITAGE Family Study. , 1997, Obesity research.

[78]  K. Rothman,et al.  Relation between weight and length at birth and body mass index in young adulthood: cohort study , 1997, BMJ.

[79]  J. Blangero,et al.  Quantitative genetic analysis of arterial oxygen saturation in Tibetan highlanders. , 1997, Human biology.

[80]  M. Goran.  Genetic Influences on Human Energy Expenditure and Substrate Utilization , 1997, Behavior genetics.

[81]  J. Diamond,et al.  Maximal sustained energy budgets in humans and animals , 1997, Nature.

[82]  C. Slemenda,et al.  Reduced Rates of Skeletal Remodeling Are Associated with Increased Bone Mineral Density During the Development of Peak Skeletal Mass , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[83]  G. Radda,et al.  Fetal growth and insulin resistance in adult life: role of skeletal muscle morphology. , 1997, Clinical science.

[84]  N Risch,et al.  The Future of Genetic Studies of Complex Human Diseases , 1996, Science.

[85]  S. Katsuta,et al.  Heredity of muscle fiber composition and correlated response of the synergistic muscle in rats. , 1996, The American journal of physiology.

[86]  S. Leung,et al.  A follow-up study on the effects of calcium-supplement withdrawal and puberty on bone acquisition of children. , 1996, The American journal of clinical nutrition.

[87]  C. Bouchard,et al.  Genetic pleiotropy for resting metabolic rate with fat-free mass and fat mass: the Québec Family Study. , 1996, Obesity research.

[88]  D. Barlow,et al.  Gametic Imprinting in Mammals , 1995, Science.

[89]  G. Radda,et al.  A relationship between impaired fetal growth and reduced muscle glycolysis revealed by 31P magnetic resonance spectroscopy , 1995, Diabetologia.

[90]  M. Kerin,et al.  Linkage analysis and the susceptibility gene (BRCA-1) in familial breast cancer. , 1995, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[91]  T. Brutsaert,et al.  Developmental, genetic, and environmental components of aerobic capacity at high altitude. , 1995, American journal of physical anthropology.

[92]  T. Meade,et al.  Fetal and infant growth and cardiovascular risk factors in women , 1995, BMJ.

[93]  J. Blangero,et al.  Major gene for percent of oxygen saturation of arterial hemoglobin in Tibetan highlanders. , 1994, American journal of physical anthropology.

[94]  J. Stephens,et al.  Mapping by admixture linkage disequilibrium in human populations: limits and guidelines. , 1994, American journal of human genetics.

[95]  A. Razin,et al.  DNA methylation and genomic imprinting , 1994, Cell.

[96]  M. D. De Latour,et al.  Detection of allelic losses on 17q12-q21 chromosomal region in benign lesions and malignant tumors occurring in a familial context. , 1994, Oncogene.

[97]  C. Martyn,et al.  Growth in utero and serum cholesterol concentrations in adult life. , 1993, BMJ.

[98]  C. Osmond,et al.  Fetal growth and impaired glucose tolerance in men and women , 1993, Diabetologia.

[99]  David J. P. Barker.  Fetal origins of coronary heart disease. , 1993, British heart journal.

[100]  N. Stickland,et al.  Does the anatomical location of a muscle affect the influence of undernutrition on muscle fibre number? , 1992, Journal of anatomy.

[101]  C. Slemenda,et al.  Calcium supplementation and increases in bone mineral density in children. , 1992, The New England journal of medicine.

[102]  J. Weber,et al.  Closing in on a breast cancer gene on chromosome 17q. , 1992, American journal of human genetics.

[103]  S L Hui,et al.  Role of physical activity in the development of skeletal mass in children , 1991, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[104]  A. Amery,et al.  Inheritance of acute cardiac changes during bicycle exercise: an echocardiographic study in twins. , 1991, Medicine and science in sports and exercise.

[105]  C Osmond,et al.  Fetal and infant growth and impaired glucose tolerance at age 64. , 1991, BMJ.

[106]  A. Amery,et al.  Inheritance of blood pressure and haemodynamic phenotypes measured at rest and during supine dynamic exercise. , 1991, Journal of hypertension.

[107]  A. Amery,et al.  The Inheritance of Left Ventricular Structure and Function Assessed by Imaging and Doppler Echocardiography , 1991, American heart journal.

[108]  C. Bouchard,et al.  Genetic effect in resting and exercise metabolic rates. , 1989, Metabolism: clinical and experimental.

[109]  K. Weiss,et al.  Admixture as a tool for finding linked genes and detecting that difference from allelic association between loci. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[110]  S. J. Wilson,et al.  A critical period for formation of secondary myotubes defined by prenatal undernourishment in rats. , 1988, Development.

[111]  D. Mccormick.  Sequence the Human Genome , 1986, Bio/Technology.

[112]  C. Bouchard,et al.  Genetic effects in human skeletal muscle fiber type distribution and enzyme activities. , 1986, Canadian journal of physiology and pharmacology.

[113]  Rudolph Am.  The fetal circulation and its response to stress. , 1984 .

[114]  A. Young,et al.  A polymorphic DNA marker genetically linked to Huntington's disease , 1983, Nature.

[115]  C. Bouchard,et al.  GENETICS OF PHYSIOLOGICAL FITNESS AND MOTOR PERFORMANCE , 1983, Exercise and sport sciences reviews.

[116]  N. Cameron,et al.  Longitudinal comparison of aerobic power in active and inactive boys aged 7.0 to 17.0 years. , 1981, Annals of human biology.

[117]  F. Rothhammer,et al.  Part IV: Genes and epidemiology in anthropological adaptation studies: Familial correlations in lung function in populations residing at different altitudes in Chile , 1980 .

[118]  A. Thorstensson,et al.  Skeletal muscle fibres and muscle enzyme activities in monozygous and dizygous twins of both sexes. , 1977, Acta physiologica Scandinavica.

[119]  J. Dempsey,et al.  Effects of acute through life-long hypoxic exposure on exercise pulmonary gas exchange. , 1971, Respiration physiology.

[120]  R. Elston,et al.  A general model for the genetic analysis of pedigree data. , 1971, Human heredity.

[121]  Cedric A. B. Smith,et al.  Introduction to Quantitative Genetics , 1960 .

[122]  P. Poulsen,et al.  Heritability of insulin secretion, peripheral and hepatic insulin action, and intracellular glucose partitioning in young and old Danish twins. , 2005, Diabetes.

[123]  C. Bouchard,et al.  The human gene map for performance and health-related fitness phenotypes: the 2004 update. , 2005, Medicine and science in sports and exercise.

[124]  J. Kaprio,et al.  Heritability of maximal isometric muscle strength in older female twins. , 2004, Journal of applied physiology.

[125]  C. Bouchard,et al.  The human gene map for performance and health-related fitness phenotypes: the 2003 update. , 2004, Medicine and science in sports and exercise.

[126]  C. Osmond,et al.  Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth , 2004, Diabetologia.

[127]  C. Bouchard,et al.  A Quantitative Trait Locus on 7 q 31 for the Changes in Plasma Insulin in Response to Exercise Training The HERITAGE Family Study , 2003 .

[128]  C. Bouchard,et al.  Familial aggregation of exercise heart rate and blood pressure in response to 20 weeks of endurance training: the HERITAGE family study. , 2003, International journal of sports medicine.

[129]  I. Rudan,et al.  Interpretation of genetic association studies in complex disease , 2002, The Pharmacogenomics Journal.

[130]  C. Bouchard,et al.  The human gene map for performance and health-related fitness phenotypes: the 2001 update. , 2002, Medicine and science in sports and exercise.

[131]  G. Rodas,et al.  Heritability of explosive power and anaerobic capacity in humans , 2002, European Journal of Applied Physiology.

[132]  International Human Genome Sequencing Consortium.  Initial sequencing and analysis of the human genome , 2001, Nature.

[133]  A. Jackson,et al.  Nutrients, growth, and the development of programmed metabolic function. , 2000, Advances in experimental medicine and biology.

[134]  C. Bouchard,et al.  The Na+-K+-ATPase α2 gene and trainability of cardiorespiratory endurance: The HERITAGE Family Study , 2000 .

[135]  R. Lorentzon,et al.  Influence of Heredity and Environment on Bone Density in Adolescent Boys: A Parent–Offspring Study , 1999, Osteoporosis International.

[136]  C. Bouchard,et al.  Familial aggregation of body mass index and subcutaneous fat measures in the longitudinal Québec family study , 1999, Genetic epidemiology.

[137]  C. Bouchard,et al.  Genetics of abdominal visceral fat levels , 1999, American journal of human biology : the official journal of the Human Biology Council.

[138]  P. Poulsen,et al.  Heritability of Type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance – a population-based twin study , 1999, Diabetologia.

[139]  L. Pérusse,et al.  Role of genetic factors in childhood obesity and in susceptibility to dietary variations. , 1999, Annals medicus.

[140]  J Blangero,et al.  Percent of oxygen saturation of arterial hemoglobin among Bolivian Aymara at 3,900-4,000 m. , 1999, American journal of physical anthropology.

[141]  C. Bouchard,et al.  Role of genetic factors in childhood obesity and in susceptibility to dietary variations. , 1999, Annals of medicine.

[142]  I. Day,et al.  Insulin-like growth factor II (IGF-II). , 1998, The international journal of biochemistry & cell biology.

[143]  E. Devor.  Genetics of fitness and physical performance. , 1998 .

[144]  A. R. Frisancho,et al.  Developmental, genetic, and environmental components of lung volumes at high altitude , 1997, American journal of human biology : the official journal of the Human Biology Council.

[145]  P. McKeigue,et al.  Mapping genes underlying ethnic differences in disease risk by linkage disequilibrium in recently admixed populations. , 1997, American journal of human genetics.

[146]  J. Stephens,et al.  Linkage disequilibrium in admixed populations: applications in gene mapping. , 1994, The Journal of heredity.

[147]  R. Eckhardt.  Population Studies on Human Adaptation and Evolution in the Peruvian Andes , 1993 .

[148]  J. Blangero,et al.  Multivariate segregation analysis using the mixed model , 1991, Genetic epidemiology.

[149]  A. Amery,et al.  Inheritance of heart structure and physical exercise capacity: a study of left ventricular structure and exercise capacity in 7-year-old twins. , 1990, European heart journal.

[150]  A. Rudolph.  The fetal circulation and its response to stress. , 1984, Journal of developmental physiology.

[151]  J. Karlsson,et al.  Physical performance, skeletal muscle enzyme activities, and fibre types in monozygous and dizygous twins of both sexes. , 1979, Acta physiologica Scandinavica. Supplementum.

[152]  R. Fisher.  XV.—The Correlation between Relatives on the Supposition of Mendelian Inheritance. , 1919, Transactions of the Royal Society of Edinburgh.

[153]  L. Penrose,et al.  THE CORRELATION BETWEEN RELATIVES ON THE SUPPOSITION OF MENDELIAN INHERITANCE , 2022 .