Retinal blood vessel width measured on color fundus photographs by image analysis.

The purpose of this paper was to develop a technique using computerized image analysis to measure the width of retinal arteries and veins on color fundus photographs. The width of the retinal vessel was determined from digitized fundus photographs by programs based on edge detection and boundary tracing. The average vessel width was determined at different distances or eccentricities from the center of the optic disc and using various lengths of vessel segment. Measurements of superior and inferior temporal vessel width for 20 eyes by 2 operators showed that about 75% of the measurements could be obtained without the use of plan points. The average percent coefficient of variation of the measurements was 2.17% for 3 measurements of each vessel. This technique provides a reproducible and objective method for obtaining the following parameters: the edges of the vessel, the length of the vessel segment to be measured, location of the measurement along the vessel and subsequent retinal vessel width. This technique is readily suitable for application to clinical studies particularly clinical trials.

[1]  J. C. Parr,et al.  Comparison of methods of measuring vessel widths on retinal photographs and the effect of fluorescein injection on apparent retinal vessel calibers. , 1969, American journal of ophthalmology.

[2]  J. Griffiths,et al.  Measurement of Apparent Vessel Width in Fluorescence Angiography of the Fundus oculi , 1974 .

[3]  K. Majewska,et al.  Computer data processing in the examination of retinal vessels in essential hypertension and atherosclerosis. , 1976, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde.

[4]  T. Sandor,et al.  Reproducibility of the densitometric analysis of fluorescein angiograms. , 1981, International journal of bio-medical computing.

[5]  I. Constable,et al.  Image splitting--a technique for measuring retinal vascular reactivity. , 1981, The British journal of ophthalmology.

[6]  P. Nagin,et al.  Measurement of fluorescein angiograms of the optic disc and retina using computerized image analysis. , 1985, Ophthalmology.

[7]  P. Nagin,et al.  The reproducibility of computerized boundary analysis for measuring optic disc pallor in the normal optic disc. , 1985, Ophthalmology.

[8]  B. Petrig,et al.  Autoregulation of human retinal blood flow. An investigation with laser Doppler velocimetry. , 1986, Investigative ophthalmology & visual science.

[9]  Oddbjørn Engvold,et al.  Microphotometry of the blood column and the light streak on retinal vessels in fundus photographs , 1986 .

[10]  D. Hatchell,et al.  Measurement of retinal blood vessel width using computerized image analysis. , 1988, Investigative ophthalmology & visual science.

[11]  The calibre changes of retinal vessels subject to prolonged hyperoxia. , 1988, Experimental eye research.

[12]  J. Weiter,et al.  Effects of optic atrophy on retinal blood flow and oxygen saturation in humans. , 1989, Archives of ophthalmology.

[13]  J. Jonas,et al.  Parapapillary retinal vessel diameter in normal and glaucoma eyes. I. Morphometric data. , 1989, Investigative ophthalmology & visual science.

[14]  A Cymerman,et al.  An automated method of quantifying retinal vascular responses during exposure to novel environmental conditions. , 1990, Ophthalmology.

[15]  O. Brinchmann‐Hansen,et al.  The response of the light reflex of retinal vessels to reduced blood pressure in hypertensive patients , 1990, Acta ophthalmologica.

[16]  E. Kohner,et al.  The Effect of ß Blockers on Retinal Blood Flow in Diabetic Patients , 1991, European journal of ophthalmology.

[17]  Automatische Messung retinaler Gefässdurchmesser , 1991 .

[18]  Dian X. Shi,et al.  Intraocular Pressure-denpendent Retinal Vascular Change in Adult Chronic Open-angle Glaucoma Patients , 1991 .

[19]  W. Vilser,et al.  [Measuring retinal vascular diameter using the scanning laser ophthalmoscope and computer. Initial results]. , 1992, Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft.

[20]  E. Kohner,et al.  Vessel diameter changes during the cardiac cycle , 1994, Eye.

[21]  E M Kohner,et al.  Accurate vessel width measurement from fundus photographs: a new concept. , 1994, The British journal of ophthalmology.