Development of Tumor-Targeting pH Sensitive Hydroxyapatite Porous Nanoplate Based Drug Nanocarrier for Cancer Therapy Applications

Herein, we report an eco-friendly hydrothermal technique was adopted for the synthesis of hydroxyapatite porous nanoplates (HAP PNPs) using carboxymethylcellulose calcium salt as a biomolecular calcium source as well as structure directing template. Systematic characterizations tools were used to analysis the physico-chemical properties of the samples. The formation mechanism was established for understanding the growth of HAp PNPs. Moreover, HAP PNPs used for pH-triggered release of electrostatically bound Andrographolide anticancer drug into A431 cell lines toward cancer therapy applications. Significance of this study confirms that the HAp with porous structure may enhance the drug loading capacity and pH-sensitive drug release, which far greater at acidic pH 4.4 than at pH 7.0 and 9.0. Also, the cytotoxicity studies were confirming that the prepared samples show higher biocompatibility. Therefore, the present results Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 19 November 2018 © 2018 by the author(s). Distributed under a Creative Commons CC BY license. 2 suggest that the distinctive characteristics of HAp PNPs can be exploited for the development of tumor-targeting pH sensitive drug nanocarrier.