Symposium review: drug discovery, development and clinical research in academia.

The development of new drugs for the pharmacological treatment of diseases is a costly and time-consuming process. The pharmaceutical industry has traditionally played the main role in the discovery, development, manufacturing and marketing of new drugs. However, in recent years, the role of academia in the process of drug discovery and development, and its eventual translation into clinical applications has steadily increased. At the occasion of their 95th anniversary, the School of Pharmacy at the University of Puerto Rico organized a symposium titled "Drug Discovery, Development and Clinical Research in Academia". This article presents a summary of the symposium presentations and the potential role of academic drug discovery and development as a complement to the pharmaceutical manufacturing industry in Puerto Rico.

[1]  Z. Estrov,et al.  WP744, a novel anthracycline with enhanced proapoptotic and antileukemic activity. , 2001, Anticancer research.

[2]  A. Verkman Drug discovery in academia. , 2004, American journal of physiology. Cell physiology.

[3]  S. Franzblau,et al.  Low-Oxygen-Recovery Assay for High-Throughput Screening of Compounds against Nonreplicating Mycobacterium tuberculosis , 2007, Antimicrobial Agents and Chemotherapy.

[4]  I. Kola,et al.  Can the pharmaceutical industry reduce attrition rates? , 2004, Nature Reviews Drug Discovery.

[5]  K. Ginalski,et al.  Efficacy of 2-halogen substituted d-glucose analogs in blocking glycolysis and killing “hypoxic tumor cells” , 2006, Cancer Chemotherapy and Pharmacology.

[6]  John S Lazo,et al.  Building a Pharmacological Lexicon: Small Molecule Discovery in Academia , 2007, Molecular Pharmacology.

[7]  C. Tralau-Stewart,et al.  Drug discovery: new models for industry-academic partnerships. , 2009, Drug discovery today.

[8]  K. Hess,et al.  A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo , 2007, Oncogene.

[9]  E. Kennelly,et al.  A traditional method of Cinnamomum carolinense preparation eliminates safrole from a therapeutic Pohnpean tea. , 2005, Journal of ethnopharmacology.

[10]  Aled Edwards,et al.  Open-source science to enable drug discovery. , 2008, Drug discovery today.

[11]  E. Zerhouni The NIH Roadmap , 2003, Science.

[12]  R. Azizkhan,et al.  WP744 is a novel anthracycline with enhanced activity against neuroblastoma. , 2004, The Journal of surgical research.

[13]  L. Romero,et al.  The Belize Ethnobotany Project: safeguarding medicinal plants and traditional knowledge in Belize , 2002 .

[14]  E. Zerhouni US biomedical research: basic, translational, and clinical sciences. , 2005, JAMA.

[15]  D. Newman,et al.  Natural products as sources of new drugs over the last 25 years. , 2007, Journal of natural products.

[16]  M. Balick,et al.  Screening of anti-bacterial activity of medicinal plants from Belize (Central America). , 2003, Journal of ethnopharmacology.

[17]  L. Brady,et al.  NIMH Initiatives to Facilitate Collaborations Among Industry, Academia, and Government for the Discovery and Clinical Testing of Novel Models and Drugs for Psychiatric Disorders , 2009, Neuropsychopharmacology.

[18]  Didier Leroy,et al.  Drugging the Plasmodium kinome: the benefits of academia-industry synergy. , 2008, Trends in pharmacological sciences.

[19]  S. Cole,et al.  New Approaches to Filling the Gap in Tuberculosis Drug Discovery , 2007, PLoS medicine.

[20]  R. W. Hansen,et al.  The price of innovation: new estimates of drug development costs. , 2003, Journal of health economics.