Physical Stress as a Factor in Tissue Growth and Remodeling

The science of tissue engineering seeks to understand the behavior of living tissues, to control their growth and resorption, to produce them in desired quantities and to make them work for the benefit of man. It rests on several foundations, of which the most important are the molecular biological one and the biomechanical one. The importance of physical stress is well known. For example, high blood pressure or excessive flow causes hypertrophy of the heart.; whether a healing fracture in bone will calcify or not depends on the nature and magnitude of the stress acting in the bone. Similarly, the success of culturing and application of artificial tissues to man will depend on proper stress conditions.

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