A Qualitative Systematic Review

[1]  R. Ledeen,et al.  Chronic opioid treatment of neuroblastoma X dorsal root ganglion neuron hybrid F11 cells results in elevated GM1 ganglioside and cyclic adenosine monophosphate levels and onset of naloxone‐evoked decreases in membrane K+ currents , 1995, Journal of neuroscience research.

[2]  E. Way,et al.  Hyperalgesic effects of divalent cations and antinociceptive effects of a calcium chelator in naive and morphine-dependent mice. , 1980, The Journal of pharmacology and experimental therapeutics.

[3]  R. Lewis,et al.  A withdrawal hyperalgesia test for physical dependence: evaluation of mu and mixed-partial opioid agonists. , 1983, Journal of pharmacological methods.

[4]  N. Barbaro,et al.  Morphine analgesia and acute physical dependence: rapid onset of two opposing, dose-related processes , 1990, Brain Research.

[5]  J. Eisenach,et al.  Intravenous Remifentanil Produces Withdrawal Hyperalgesia in Volunteers with Capsaicin-Induced Hyperalgesia , 2003, Anesthesia and analgesia.

[6]  F. Colpaert,et al.  Opioid hyperalgesia and tolerance versus 5-HT1A receptor-mediated inverse tolerance. , 2003, Trends in pharmacological sciences.

[7]  J. Deleo,et al.  The Role of Spinal Neuroimmune Activation in Morphine Tolerance/Hyperalgesia in Neuropathic and Sham-Operated Rats , 2002, The Journal of Neuroscience.

[8]  R. Hinson,et al.  Conditional hyperalgesia is elicited by environmental signals of morphine. , 1981, Behavioral and neural biology.

[9]  J. Mao,et al.  Chronic Morphine Induces Downregulation of Spinal Glutamate Transporters: Implications in Morphine Tolerance and Abnormal Pain Sensitivity , 2022 .

[10]  A. Basbaum,et al.  Formalin-evoked Fos expression in spinal cord is enhanced in morphine-tolerant rats , 1997, Brain Research.

[11]  C. Mitchell,et al.  Morphine-induced hyperalgesia in rats tested on the hot plate. , 1971, The Journal of pharmacology and experimental therapeutics.

[12]  J. Corcuff,et al.  Fentanyl Enhancement of Carrageenan-induced Long-lasting Hyperalgesia in Rats: Prevention by the N-methyl-d-aspartate Receptor Antagonist Ketamine , 2002, Anesthesiology.

[13]  Lars Arendt-Nielsen,et al.  Modulation of Remifentanil-Induced Analgesia, Hyperalgesia, and Tolerance by Small-Dose Ketamine in Humans , 2003, Anesthesia and analgesia.

[14]  W. Falls,et al.  Procedures that produce context-specific tolerance to morphine in rats also produce context-specific withdrawal. , 1989, Behavioral neuroscience.

[15]  E. Bruera,et al.  Acute neuropsychiatric findings in a patient receiving fentanyl for cancer pain , 1997, Pain.

[16]  M. Moal,et al.  Long‐lasting increased pain sensitivity in rat following exposure to heroin for the first time , 1998, The European journal of neuroscience.

[17]  S. Dunbar,et al.  Repetitive opioid abstinence causes progressive hyperalgesia sensitive to N-methyl-D-aspartate receptor blockade in the rat. , 1998, The Journal of pharmacology and experimental therapeutics.

[18]  N. Rawal,et al.  Clinical experience of long–term treatment with epidural and intrathecal opioids – a nationwide survey , 1988 .

[19]  J. Clark,et al.  Hyperalgesia during opioid abstinence: mediation by glutamate and substance p. , 2002, Anesthesia and analgesia.

[20]  Tat-Leang Lee,et al.  Role of nitric oxide in the induction and expression of morphine tolerance and dependence in mice , 1996, British journal of pharmacology.

[21]  D. Price,et al.  Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[22]  C. Hendrie Opiate dependence and withdrawal— A new synthesis? , 1985, Pharmacology Biochemistry and Behavior.

[23]  C. Ghelardini,et al.  Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine. , 2002, Pharmacological research.

[24]  R. Moore,et al.  Single dose oral dihydrocodeine for acute postoperative pain , 2000 .

[25]  C. Rivat,et al.  Opioid-induced hyperalgesia: abnormal or normal pain? , 2003, Neuroreport.

[26]  M. Rowbotham,et al.  Effect of Remifentanil on Pain and Secondary Hyperalgesia Associated with the Heat–Capsaicin Sensitization Model in Healthy Volunteers , 2001, Anesthesiology.

[27]  H. Fields,et al.  Hyperalgesia during acute opioid abstinence: evidence for a nociceptive facilitating function of the rostral ventromedial medulla , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[28]  Intraadministration associations: conditional hyperalgesia elicited by morphine onset cues. , 2002 .

[29]  A. Somogyi,et al.  Steady‐state pharmacokinetics and pharmacodynamics in methadone maintenance patients: Comparison of those who do and do not experience withdrawal and concentration‐effect relationships , 1999, Clinical pharmacology and therapeutics.

[30]  J. Sloan,et al.  Opioid and nicotinic medullary hyperalgesic influences in the decerebrated rat , 1988, Pharmacology Biochemistry and Behavior.

[31]  S. Dunbar,et al.  Periodic abstinence enhances nociception without significantly altering the antinociceptive efficacy of spinal morphine in the rat , 2003, Neuroscience Letters.

[32]  K. Shen,et al.  Neuraminidase inhibitor, oseltamivir blocks GM1 ganglioside-regulated excitatory opioid receptor-mediated hyperalgesia, enhances opioid analgesia and attenuates tolerance in mice , 2004, Brain Research.

[33]  J. Levine,et al.  Mu-opioid agonist enhancement of prostaglandin-induced hyperalgesia in the rat: A G-protein βγ subunit-mediated effect? , 1995, Neuroscience.

[34]  J. Levine,et al.  Dissociation of Tolerance and Dependence for Opioid Peripheral Antinociception in Rats , 1997, The Journal of Neuroscience.

[35]  D. Price,et al.  Increases in protein kinase C gamma immunoreactivity in the spinal cord dorsal horn of rats with painful mononeuropathy , 1995, Neuroscience Letters.

[36]  M. Angst,et al.  A murine model of opioid-induced hyperalgesia. , 2001, Brain research. Molecular brain research.

[37]  R. A. Hughes Codeine analgesic and morphine hyperalgesic effects on thermal nociception in domestic fowl , 1990, Pharmacology Biochemistry and Behavior.

[38]  D. Kooy,et al.  Hyperalgesia mediated by peripheral opiate receptors in the rat , 1985, Behavioural Brain Research.

[39]  W. Ling,et al.  Pain responses in methadone-maintained opioid abusers. , 2000, Journal of pain and symptom management.

[40]  G. McNally,et al.  Effects of systemic, intracerebral, or intrathecal administration of an N-methyl-D-aspartate receptor antagonist on associative morphine analgesic tolerance and hyperalgesia in rats. , 1998, Behavioral neuroscience.

[41]  A. Caraceni,et al.  Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine , 1991, Pain.

[42]  The role of contextual cues on counterirritation in the development process of analgesic tolerance to morphine. , 2002, Life sciences.

[43]  Xiao-jun Xu,et al.  Genetic differences in the antinociceptive effect of morphine and its potentiation by dextromethorphan in rats , 1999, Neuroscience Letters.

[44]  R. Macdonald,et al.  Opiate alkaloids antagonize postsynaptic glycine and GABA responses: Correlation with convulsant action , 1982, Brain Research.

[45]  J. Mao Opioid-induced abnormal pain sensitivity: implications in clinical opioid therapy , 2002, Pain.

[46]  S. Maier,et al.  Route of morphine administration modulates conditioned analgesic tolerance and hyperalgesia , 1994, Pharmacology Biochemistry and Behavior.

[47]  C. Himmelsbach THE MORPHINE ABSTINENCE SYNDROME, ITS NATURE AND TREATMENT* , 1941 .

[48]  T. Yaksh,et al.  High Doses of Spinal Morphine Produce a Nonopiate Receptormediated Hyperesthesia: Clinical and Theoretic Implications , 1986, Anesthesiology.

[49]  S. Tiffany,et al.  Associative morphine tolerance in the rat: examinations of compensatory responding and cross-tolerance with stress-induced analgesia. , 1989, Behavioral and neural biology.

[50]  G. Lighthall,et al.  Heme oxygenase type 2 modulates behavioral and molecular changes during chronic exposure to morphine , 2003, Neuroscience.

[51]  L. Cox,et al.  Context-specific morphine tolerance on the paw-pressure and tail-shock vocalization tests: evidence of associative tolerance without conditioned compensatory responding , 1999, Psychopharmacology.

[52]  N. Barbaro,et al.  Hyperalgesia during naloxone-precipitated withdrawal from morphine is associated with increased on-cell activity in the rostral ventromedial medulla. , 1990, Somatosensory & motor research.

[53]  B. Blumenkopf,et al.  Comparison of subjective and objective analgesic effects of intravenous and intrathecal morphine in chronic pain patients by heat beam dolorimetry , 1989, Pain.

[54]  G. Wilson,et al.  Morphine hyperalgesia: A case report , 2003, The American journal of hospice & palliative care.

[55]  H. Akil,et al.  Role of corticotropin-releasing hormone in the amygdala and bed nucleus of the stria terminalis in the behavioral, pain modulatory, and endocrine consequences of opiate withdrawal , 2002, Neuroscience.

[56]  D. Carr,et al.  Addition of ultralow dose naloxone to postoperative morphine PCA: unchanged analgesia and opioid requirement but decreased incidence of opioid side effects , 2004, Pain.

[57]  Xiao-jun Xu,et al.  The development of morphine tolerance and dependence in rats with chronic pain , 1997, Brain Research.

[58]  R. F. Westbrook,et al.  Conditioned Tolerance to Morphine Hypoalgesia: Compensatory Hyperalgesia in the Experimental Group or Conditioned Hypoalgesia in the Control Group? , 1992, The Quarterly journal of experimental psychology. B, Comparative and physiological psychology.

[59]  T. Yaksh,et al.  Pharmacology of the allodynia in rats evoked by high dose intrathecal morphine. , 1988, The Journal of pharmacology and experimental therapeutics.

[60]  T. Kanui,et al.  Hyperalgesia following administration of morphine and pethidine in the root rat (Tachyoryctes splendens). , 1995, Journal of veterinary pharmacology and therapeutics.

[61]  G. Guilbaud,et al.  Paradoxical hyperalgesic effect of exceedingly low doses of systemic morphine in an animal model of persistent pain (Freund's adjuvant-induced arthritic rats) , 1987, Brain Research.

[62]  B. Milne,et al.  Intrathecal Clonidine: Analgesia and Effect on Opiate Withdrawal in the Rat , 1985, Anesthesiology.

[63]  Xiao-jun Xu,et al.  Treatment of chronic allodynia in spinally injured rats: effects of intrathecal selective opioid receptor agonists , 1998, Pain.

[64]  S. Dunbar,et al.  The Effect of Spinal Ibuprofen on Opioid Withdrawal in the Rat , 2000, Anesthesia and analgesia.

[65]  J. Harro,et al.  Cholecystokinin receptor binding in morphine analgesia: Tolerance, withdrawal and abstinence , 1994, Neuropeptides.

[66]  D. M. Grilly,et al.  Acute morphine dependence: Effects observed in shock and light discrimination tasks , 2004, Psychopharmacology.

[67]  M. Moal,et al.  Opiate tolerance to daily heroin administration: an apparent phenomenon associated with enhanced pain sensitivity , 1999, Neuroscience.

[68]  J. Kessler,et al.  Kappa opioid receptors participate in nerve growth factor-induced hyperalgesia , 1995, Neuroscience.

[69]  Jason M. White,et al.  Methadone maintenance patients are cross-tolerant to the antinociceptive effects of morphine , 2001, Pain.

[70]  H. Muñoz,et al.  No clinical evidence of acute opioid tolerance after remifentanil-based anaesthesia. , 2001, British journal of anaesthesia.

[71]  J. Kendig,et al.  Mechanical allodynia and thermal hyperalgesia upon acute opioid withdrawal in the neonatal rat , 2004, Pain.

[72]  T. Jensen,et al.  Disappearance of morphine-induced hyperalgesia after discontinuing or substituting morphine with other opioid agonists , 1994, Pain.

[73]  R. Hill,et al.  Intrathecal injection of a ϰ opioid agonist produces hyperalgesia in the guinea pig , 1988 .

[74]  M. Moal,et al.  Evidence for opiate-activated NMDA processes masking opiate analgesia in rats , 1999, Brain Research.

[75]  Z. Wiesenfeld‐Hallin,et al.  Genetic differences in morphine sensitivity, tolerance and withdrawal in rats , 1998, Brain Research.

[76]  M. Davies,et al.  Dexmedetomidine fails to cause hyperalgesia after cessation of chronic administration. , 2003, Anesthesia and analgesia.

[77]  H. Fields,et al.  Naloxone dose dependently produces analgesia and hyperalgesia in postoperative pain , 1979, Nature.

[78]  J. Wesevich,et al.  Effects of prophylactic nalmefene on the incidence of morphine-related side effects in patients receiving intravenous patient-controlled analgesia. , 1999, Anesthesiology.

[79]  D. Carr,et al.  The combination of low dose of naloxone and morphine in PCA does not decrease opioid requirements in the postoperative period , 2002, Pain.

[80]  C. Woolf Analgesia and hyperalgesia produced in the rat by intrathecal naloxone , 1980, Brain Research.

[81]  D. Price,et al.  Spatial patterns of increased spinal cord membrane-bound protein kinase C and their relation to increases in 14C-2-deoxyglucose metabolic activity in rats with painful peripheral mononeuropathy. , 1993, Journal of neurophysiology.

[82]  H. L. Andrews THE EFFECT OF OPIATES ON THE PAIN THRESHOLD IN POST-ADDICTS. , 1943, The Journal of clinical investigation.

[83]  V. Kayser,et al.  The development of pain-related behaviour and opioid tolerance after neuropathy-inducing surgery and sham surgery , 2000, PAIN.

[84]  S. Heger,et al.  Morphine induced allodynia in a child with brain tumour. , 1999, BMJ.

[85]  M. Morgan,et al.  EHAVIORAL AND ELECTROPHYSIOLOGICAL EVIDENCE FOR OLERANCE TO CONTINUOUS MORPHINE ADMINISTRATION INTO HE VENTROLATERAL PERIAQUEDUCTAL , 2004 .

[86]  D. Price,et al.  Pain-related increases in spinal cord membrane-bound protein kinase C following peripheral nerve injury , 1992, Brain Research.

[87]  M. Le Moal,et al.  Progressive Enhancement of Delayed Hyperalgesia Induced by Repeated Heroin Administration: A Sensitization Process , 2001, Journal of Neuroscience.

[88]  S. Maeda,et al.  Intracerebroventricular treatment of mice with pertussis toxin induces hyperalgesia and enhances 3H-nitrendipine binding to synaptic membranes: Similarity with morphine tolerance , 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

[89]  W. Martin,et al.  Hyperalgesic and analgesic actions of morphine, U50-488, naltrexone, and (−)-lobeline in the rat brainstem , 1994, Pharmacology Biochemistry and Behavior.

[90]  G. Guilbaud,et al.  Dose-dependent analgesic and hyperalgesic effects of systemic naloxone in arthritic rats , 1981, Brain Research.

[91]  C. Woolf Intrathecal high dose morphine produces hyperalgesia in the rat , 1981, Brain Research.

[92]  J. Deleo,et al.  Attenuation of Morphine Tolerance, Withdrawal-Induced Hyperalgesia, and Associated Spinal Inflammatory Immune Responses by Propentofylline in Rats , 2004, Neuropsychopharmacology.

[93]  Chih-Shung Wong,et al.  Morphine tolerance increases [3H]MK‐801 binding affinity and constitutive neuronal nitric oxide synthase expression in rat spinal cord , 2000 .

[94]  N. Salimova,et al.  Interaction between alcohol deprivation and morphine withdrawal in mice. , 1993, Drug and alcohol dependence.

[95]  J. C. Doerr,et al.  Amniotic-fluid ingestion enhances morphine analgesia during morphine tolerance and withdrawal in rats , 1991, Physiology & Behavior.

[96]  J. Eisenach,et al.  Intrathecal Ketorolac Reverses Hypersensitivity following Acute Fentanyl Exposure , 2002, Anesthesiology.

[97]  D. M. Grilly,et al.  Morphine dependence in rats assessed in a shock discrimination task , 2004, Psychopharmacology.

[98]  F. Graeff,et al.  Opioid mediation of the antiaversive and hyperalgesic actions of bradykinin injected into the dorsal periaqueductal gray of the rat , 1992, Physiology & Behavior.

[99]  W. Martin,et al.  Opioid and nicotinic analgesic and hyperalgesic loci in the rat brain stem. , 1992, The Journal of pharmacology and experimental therapeutics.

[100]  S. Hansen,et al.  Is development of hyperalgesia, allodynia and myoclonus related to morphine metabolism during long‐term administration?: Six case histories , 1998, Acta anaesthesiologica Scandinavica.

[101]  Martin S Angst,et al.  Short-term infusion of the μ-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal , 2003, Pain.

[102]  P. Glass,et al.  Opioid‐sparing Effects of a Low‐dose Infusion of Naloxone in Patient‐administered Morphine Sulfate , 1997, Anesthesiology.

[103]  T. Yaksh,et al.  Effect of transient naloxone antagonism on tolerance development in rats receiving continuous spinal morphine infusion , 1997, Pain.

[104]  K. Tan-No,et al.  Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors. , 2002, Brain research. Molecular brain research.

[105]  Peter A. Smith,et al.  Morphine-3 (cid:1) - D -glucuronide Suppresses Inhibitory Synaptic Transmission in Rat Substantia Gelatinosa , 2002 .

[106]  H. Tilson,et al.  The effects of p-chlorophenylalanine on morphine analgesia, tolerance and dependence development in two strains of rats , 1974, Psychopharmacologia.

[107]  D. Price,et al.  Continuous co-administration of dextromethorphan or MK-801 with morphine: attenuation of morphine dependence and naloxone-reversible attenuation of morphine tolerance , 1996, Pain.

[108]  L. Paalzow,et al.  Modeling of tolerance development and rebound effect during different intravenous administrations of morphine to rats. , 1993, The Journal of pharmacology and experimental therapeutics.

[109]  M. Angst,et al.  Opioid-Induced Hyperalgesia and Incisional Pain , 2001, Anesthesia and analgesia.

[110]  J. Schüttler,et al.  Naloxone provokes similar pain facilitation as observed after short-term infusion of remifentanil in humans , 2003, Pain.

[111]  B. Bie,et al.  Presynaptic Mechanism for Anti-Analgesic and Anti-Hyperalgesic Actions of κ-Opioid Receptors , 2003, The Journal of Neuroscience.

[112]  A. Basbaum,et al.  Contribution of sacral spinal cord neurons to the autonomic and somatic consequences of withdrawal from morphine in the rat , 1997, Brain Research.

[113]  S. Siegel,et al.  The role of cholecystokinin in conditional compensatory responding and morphine tolerance in rats. , 2001, Behavioral neuroscience.

[114]  T. Yaksh,et al.  Spinal amino acid release and repeated withdrawal in spinal morphine tolerant rats , 2003, British journal of pharmacology.

[115]  P. Siddall,et al.  Allodynia after acute intrathecal morphine administration in a patient with neuropathic pain after spinal cord injury. , 2003, Anesthesia and analgesia.

[116]  D. Sessler,et al.  Acute Opioid Tolerance: Intraoperative Remifentanil Increases Postoperative Pain and Morphine Requirement , 2000, Anesthesiology.

[117]  T. Vanderah,et al.  Tonic Descending Facilitation from the Rostral Ventromedial Medulla Mediates Opioid-Induced Abnormal Pain and Antinociceptive Tolerance , 2001, The Journal of Neuroscience.

[118]  M. Angst,et al.  Management of Perioperative Pain in Patients Chronically Consuming Opioids , 2004, Regional Anesthesia & Pain Medicine.

[119]  J. Kendig,et al.  Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C ε and γ , 2004, Pain.

[120]  E. Okuda‐Ashitaka,et al.  Characterization of nociceptin hyperalgesia and allodynia in conscious mice , 1997, British journal of pharmacology.

[121]  S. Eldabe,et al.  Does intrathecal fentanyl produce acute cross-tolerance to i.v. morphine? , 1997, British journal of anaesthesia.

[122]  E. Bruera,et al.  Severe opioid toxicity and somatization of psychosocial distress in a cancer patient with a background of chemical dependence. , 1997, Journal of pain and symptom management.

[123]  S. Maier,et al.  A Role for Proinflammatory Cytokines and Fractalkine in Analgesia, Tolerance, and Subsequent Pain Facilitation Induced by Chronic Intrathecal Morphine , 2004, The Journal of Neuroscience.

[124]  K. Shen,et al.  Acute thermal hyperalgesia elicited by low-dose morphine in normal mice is blocked by ultra-low-dose naltrexone, unmasking potent opioid analgesia , 2001, Brain Research.

[125]  S. Ho,et al.  Intraoperative high dose fentanyl induces postoperative fentanyl tolerance , 1999, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[126]  G. Guilbaud,et al.  Cross-tolerance between analgesic low doses of morphine and naloxone in arthritic rats , 1987, Brain Research.

[127]  W. Ma,et al.  Expression of calcitonin gene-related peptide, substance P and protein kinase C in cultured dorsal root ganglion neurons following chronic exposure to mu, delta and kappa opiates , 2002, Neuroscience.

[128]  S. Siegel,et al.  Evidence from rats that morphine tolerance is a learned response. , 1975, Journal of comparative and physiological psychology.

[129]  J. Fujimoto,et al.  Differential contribution of descending serotonergic and noradrenergic systems to central Tyr-D-Ala2-Gly-NMePhe4-Gly-ol5 (DAMGO) and morphine-induced antinociception in mice. , 1991, The Journal of pharmacology and experimental therapeutics.

[130]  T. Jensen,et al.  Hyperalgesia and myoclonus in terminal cancer patients treated with continuous intravenous morphine , 1993, Pain.

[131]  D. Elashoff,et al.  Withdrawal hyperalgesia after acute opioid physical dependence in nonaddicted humans: a preliminary study. , 2003, The journal of pain : official journal of the American Pain Society.

[132]  K. Shen,et al.  Antagonists at excitatory opioid receptors on sensory neurons in culture increase potency and specificity of opiate analgesics and attenuate development of tolerance/dependence , 1994, Brain Research.

[133]  U. Schall,et al.  Pain perception of intravenous heroin users on maintenance therapy with levomethadone. , 1996, Pharmacopsychiatry.

[134]  E. Zhang,et al.  Dynorphin Promotes Abnormal Pain and Spinal Opioid Antinociceptive Tolerance , 2000, The Journal of Neuroscience.

[135]  J. Clark,et al.  Chronic pain prevalence and analgesic prescribing in a general medical population. , 2002, Journal of pain and symptom management.

[136]  D. Elashoff,et al.  Precipitated opioid withdrawal across acute physical dependence induction methods , 2004, Pharmacology Biochemistry and Behavior.

[137]  J. Levine,et al.  Multiple Receptors Involved in Peripheral α2, μ, and A1 Antinociception, Tolerance, and Withdrawal , 1997, The Journal of Neuroscience.

[138]  T. Kanui,et al.  Effects of pethidine, acetylsalicylic acid, and indomethacin on pain and behavior in the mole-rat , 1993, Pharmacology Biochemistry and Behavior.

[139]  J. Mogil,et al.  Genetic variation in morphine analgesic tolerance A survey of 11 inbred mouse strains , 2002, Pharmacology Biochemistry and Behavior.

[140]  P. Pauwels,et al.  Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia , 2002, Neuropharmacology.

[141]  E. Bradley,et al.  The Effect of Ketamine on Opioid-Induced Acute Tolerance: Can It Explain Reduction of Opioid Consumption with Ketamine-Opioid Analgesic Combinations? , 2000, Anesthesia and analgesia.

[142]  C. Hendrie Naloxone-sensitive hyperalgesia follows analgesia induced by morphine and environmental stimulation , 1989, Pharmacology Biochemistry and Behavior.

[143]  J. Levine,et al.  Different Mechanisms Mediate Development and Expression of Tolerance and Dependence for Peripheral μ-Opioid Antinociception in Rat , 1997, The Journal of Neuroscience.

[144]  M. Moal,et al.  Acute tolerance associated with a single opiate administration: involvement of N-methyl-d-aspartate-dependent pain facilitatory systems , 1998, Neuroscience.

[145]  Jason M. White,et al.  Hyperalgesic responses in methadone maintenance patients , 2001, Pain.

[146]  K. Shen,et al.  Cholera toxin-B subunit blocks excitatory opioid receptor-mediated hyperalgesic effects in mice, thereby unmasking potent opioid analgesia and attenuating opioid tolerance/dependence , 2001, Brain Research.

[147]  A. Basbaum,et al.  Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKCγ mutant mice , 2001, Pain.

[148]  M. Nessly,et al.  Acute pain management in patients with prior opioid consumption: a case-controlled retrospective review , 1995, Pain.

[149]  R. Maldonado,et al.  Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking the protein kinase Cγ gene , 2004, Neuropharmacology.

[150]  S. Kamerling,et al.  Possible medullary kappa hyperalgesic mechanism. I. A new potential role for endogenous opioid peptides in pain perception. , 1983, Life sciences.

[151]  S. Siegel,et al.  DRUG-ONSET CUES AS SIGNALS : INTRAADMINISTRATION ASSOCIATIONS AND TOLERANCE , 1999 .

[152]  S. Mercadante,et al.  Hyperalgesia: an emerging iatrogenic syndrome. , 2003, Journal of pain and symptom management.

[153]  A. Basbaum,et al.  Spinal cord mechanisms of opioid tolerance and dependence: Fos-like immunoreactivity expression increases in subpopulations of spinal cord neurons during withdrawal , 1996, Neuroscience.

[154]  R. A. Hughes,et al.  Morphine hyperalgesic effects on the formalin test in domestic fowl (Gallus gallus) , 1991, Pharmacology Biochemistry and Behavior.

[155]  J. Corcuff,et al.  The Role of Ketamine in Preventing Fentanyl-Induced Hyperalgesia and Subsequent Acute Morphine Tolerance , 2002, Anesthesia and analgesia.

[156]  H. Fields,et al.  Roles of α1- and α2-Adrenoceptors in the Nucleus Raphe Magnus in Opioid Analgesia and Opioid Abstinence-Induced Hyperalgesia , 2003, The Journal of Neuroscience.

[157]  E. Heinzen,et al.  Pharmacodynamics of morphine-induced neuronal nitric oxide production and antinociceptive tolerance development , 2004, Brain Research.

[158]  J. Devulder Hyperalgesia induced by high-dose intrathecal sufentanil in neuropathic pain. , 1997, Journal of neurosurgical anesthesiology.

[159]  W. Ling,et al.  Pain intolerance in opioid-maintained former opiate addicts: effect of long-acting maintenance agent. , 2001, Drug and alcohol dependence.

[160]  A. Phillips,et al.  Associative factors in tolerance to analgesia produced by electrical stimulation in the brainstem. , 1990, Behavioral neuroscience.

[161]  T. Vanderah,et al.  Sustained Morphine Exposure Induces a Spinal Dynorphin-Dependent Enhancement of Excitatory Transmitter Release from Primary Afferent Fibers , 2002, The Journal of Neuroscience.

[162]  C. Rivat,et al.  Long-lasting Hyperalgesia Induced by Fentanyl in Rats: Preventive Effect of Ketamine , 2000, Anesthesiology.

[163]  H. Tilson,et al.  Hyperalgesia during withdrawal as a means of measuring the degree of dependence in morphine dependent rats , 2004, Psychopharmacologia.

[164]  G. Rolly,et al.  A case of uncommon withdrawal symptoms after a short period of spinal morphine administration , 1996, Pain.

[165]  J. Schüttler,et al.  Differential Modulation of Remifentanil-induced Analgesia and Postinfusion Hyperalgesia by S-Ketamine and Clonidine in Humans , 2003, Anesthesiology.

[166]  J. Levine,et al.  Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[167]  M. Compton,et al.  Cold-pressor pain tolerance in opiate and cocaine abusers: correlates of drug type and use status. , 1994, Journal of pain and symptom management.

[168]  M. Kock,et al.  Questioning the cardiocirculatory excitatory effects of opioids under volatile anaesthesia. , 2004, British journal of anaesthesia.

[169]  J. Gewirtz,et al.  Potentiated startle and hyperalgesia during withdrawal from acute morphine: effects of multiple opiate exposures , 2004, Psychopharmacology.