Exploration in the cascade working mechanisms of liver injury induced by total saponins extracted from Rhizoma Dioscorea bulbifera.

[1]  Zhengtao Wang,et al.  Protection of Angelica sinensis (Oliv) Diels against hepatotoxicity induced by Dioscorea bulbifera L. and its mechanism. , 2014, Bioscience trends.

[2]  Jin Ren,et al.  Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters , 2014, Acta Pharmacologica Sinica.

[3]  Guangmin Yao,et al.  New norclerodane diterpenoids from the tubers of Dioscorea bulbifera. , 2014, Chemical & pharmaceutical bulletin.

[4]  M. Yuki,et al.  Green Tea Extract-induced Acute Hepatotoxicity in Rats , 2014, Journal of toxicologic pathology.

[5]  A. Wen,et al.  Antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis in experimental type 2 diabetic rats. , 2014, Journal of ethnopharmacology.

[6]  Zhengtao Wang,et al.  Cytokines as potential biomarkers of liver toxicity induced by Dioscorea bulbifera L. , 2014, Bioscience trends.

[7]  Weida Tong,et al.  High lipophilicity and high daily dose of oral medications are associated with significant risk for drug‐induced liver injury , 2013, Hepatology.

[8]  B. Cumurcu,et al.  Analysis of manganese superoxide dismutase (MnSOD: Ala-9Val) and glutathione peroxidase (GSH-Px: Pro 197 Leu) gene polymorphisms in mood disorders. , 2013, Bosnian journal of basic medical sciences.

[9]  Y. Hsieh,et al.  Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines , 2013, Archives of Toxicology.

[10]  H. Sohn,et al.  The antifungal activity and membrane-disruptive action of dioscin extracted from Dioscorea nipponica. , 2013, Biochimica et biophysica acta.

[11]  S. Nyberg,et al.  Role of Kupffer cells and toll-like receptor 4 in acetaminophen-induced acute liver failure. , 2013, Journal of Surgical Research.

[12]  Hartmut Jaeschke,et al.  Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. , 2012, Toxicology and applied pharmacology.

[13]  Jinyong Peng,et al.  A 90-day subchronic toxicological assessment of dioscin, a natural steroid saponin, in Sprague-Dawley rats. , 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[14]  Zheng Wang,et al.  Antitumor activity of Dioscorea bulbifera L. rhizome in vivo. , 2012, Fitoterapia.

[15]  Martin L Yarmush,et al.  Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure , 2012, Nature Biotechnology.

[16]  William M. Lee,et al.  Drug‐induced acute liver failure: Results of a U.S. multicenter, prospective study , 2010, Hepatology.

[17]  A. Jetter,et al.  Pharmacogenetics of drug‐induced liver injury , 2010, Hepatology.

[18]  Hua-Bin Li,et al.  Total Phenolic Contents and Antioxidant Capacities of Selected Chinese Medicinal Plants , 2010, International journal of molecular sciences.

[19]  G. Wang,et al.  Two New Furanoid Norditerpenes from Dioscorea bulbifera , 2009 .

[20]  Ignazio Grattagliano,et al.  Current Concepts of Mechanisms in Drug-Induced Hepatotoxicity , 2009, Current medicinal chemistry.

[21]  S. Ramaiah A toxicologist guide to the diagnostic interpretation of hepatic biochemical parameters. , 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[22]  A. Vandenberg,et al.  Risperidone- and Quetiapine-Induced Cholestasis , 2007, The Annals of pharmacotherapy.

[23]  P. Meier,et al.  Enterohepatic transport of bile salts and genetics of cholestasis. , 2005, Journal of hepatology.

[24]  Neil Kaplowitz,et al.  Idiosyncratic drug hepatotoxicity , 2005, Nature Reviews Drug Discovery.

[25]  E. Levin,et al.  Oxidative stress in toxicology: established mammalian and emerging piscine model systems. , 1998, Environmental health perspectives.

[26]  R. Edwards,et al.  Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues. , 1995, Biochemical pharmacology.

[27]  Lei Rong-rong Macroporous resin enrichment and purification of total saponins of Airpotato yam , 2011 .

[28]  M. Black,et al.  Acetaminophen hepatotoxicity. , 1980, Gastroenterology.

[29]  R. Drotman,et al.  Serum enzymes as indicators of chemically induced liver damage. , 1978, Drug and chemical toxicology.