Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers

[1]  G. le Naour,et al.  Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice , 2015, Nature Communications.

[2]  A. Vaughan,et al.  Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice. , 2015, Cell host & microbe.

[3]  T. Richie,et al.  Humanized HLA-DR4.RagKO.IL2RγcKO.NOD (DRAG) mice sustain the complex vertebrate life cycle of Plasmodium falciparum malaria , 2014, Malaria Journal.

[4]  M. Vignali,et al.  Of men in mice: the success and promise of humanized mouse models for human malaria parasite infections , 2014, Cellular microbiology.

[5]  Roger Le Grand,et al.  Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures , 2014, Nature Medicine.

[6]  G. van Gemert,et al.  Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection. , 2014, The Journal of clinical investigation.

[7]  G. Superti-Furga,et al.  Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection , 2013, Nature Medicine.

[8]  S. Bhatia,et al.  Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro , 2013, Disease Models & Mechanisms.

[9]  W. Mccarthy,et al.  Primaquine failure and cytochrome P-450 2D6 in Plasmodium vivax malaria. , 2013, The New England journal of medicine.

[10]  Mario Roederer,et al.  Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine , 2013, Science.

[11]  Iñigo Angulo-Barturen,et al.  Humanised models of infection in the evaluation of anti-malarial drugs. , 2013, Drug discovery today. Technologies.

[12]  Anne E Carpenter,et al.  A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax. , 2013, Cell host & microbe.

[13]  D. Caridha,et al.  The metabolism of primaquine to its active metabolite is dependent on CYP 2D6 , 2013, Malaria Journal.

[14]  S. Thiberge,et al.  Role of host cell traversal by the malaria sporozoite during liver infection , 2013, The Journal of experimental medicine.

[15]  Ricardo D. Solorzano,et al.  Geometric control of vascular networks to enhance engineered tissue integration and function , 2013, Proceedings of the National Academy of Sciences.

[16]  A. Vaughan,et al.  Complete Plasmodium falciparum liver-stage development in liver-chimeric mice. , 2012, The Journal of clinical investigation.

[17]  Richard J Sciotti,et al.  CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine , 2012, Malaria Journal.

[18]  S. Kappe,et al.  Plasmodium yoelii Macrophage Migration Inhibitory Factor Is Necessary for Efficient Liver-Stage Development , 2012, Infection and Immunity.

[19]  M. Mota,et al.  A toolbox to study liver stage malaria. , 2011, Trends in parasitology.

[20]  Luvena L. Ong,et al.  Humanized mice with ectopic artificial liver tissues , 2011, Proceedings of the National Academy of Sciences.

[21]  C. Rice,et al.  A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease. , 2011, Gastroenterology.

[22]  M. Suematsu,et al.  The reconstituted 'humanized liver' in TK-NOG mice is mature and functional. , 2011, Biochemical and biophysical research communications.

[23]  Pedro M. Baptista,et al.  The use of whole organ decellularization for the generation of a vascularized liver organoid , 2011, Hepatology.

[24]  Ogobara K. Doumbo,et al.  A Research Agenda to Underpin Malaria Eradication , 2011, PLoS medicine.

[25]  T. Wells,et al.  New medicines to improve control and contribute to the eradication of malaria , 2010, Malaria Journal.

[26]  S. Thiberge,et al.  Development of the malaria parasite in the skin of the mammalian host , 2010, Proceedings of the National Academy of Sciences.

[27]  Hiroshi Yagi,et al.  Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix , 2010, Nature Medicine.

[28]  C. Rice,et al.  New horizons for studying human hepatotropic infections. , 2010, The Journal of clinical investigation.

[29]  Robert W. Sauerwein,et al.  Visualisation and Quantitative Analysis of the Rodent Malaria Liver Stage by Real Time Imaging , 2009, PloS one.

[30]  L. Rénia,et al.  A pre-emptive strike against malaria's stealthy hepatic forms , 2009, Nature Reviews Drug Discovery.

[31]  K. Bendixen,et al.  Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue , 2009, Proceedings of the National Academy of Sciences.

[32]  A. Aly,et al.  Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design , 2009, Proceedings of the National Academy of Sciences.

[33]  P. Sinnis,et al.  Plasmodium sporozoite-host interactions from the dermis to the hepatocyte. , 2009, Current opinion in microbiology.

[34]  M. Manns,et al.  Humanized mice for modeling human infectious disease: challenges, progress, and outlook. , 2009, Cell host & microbe.

[35]  Hiroshi Mizumoto,et al.  An approach for formation of vascularized liver tissue by endothelial cell-covered hepatocyte spheroid integration. , 2009, Tissue engineering. Part A.

[36]  Philip Timmerman,et al.  Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development. , 2009, Chemical research in toxicology.

[37]  Zhigang Tian,et al.  Liver: An organ with predominant innate immunity , 2007, Hepatology.

[38]  Aarati R. Ranade,et al.  Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice , 2007, Nature Biotechnology.

[39]  Y. Nahmias,et al.  Endothelium-mediated hepatocyte recruitment in the establishment of liver-like tissue in vitro. , 2006, Tissue engineering.

[40]  L. Rénia,et al.  Liver-stage development of Plasmodium falciparum, in a humanized mouse model. , 2006, The Journal of infectious diseases.

[41]  Toshihiro Akaike,et al.  Enhanced liver functions of hepatocytes cocultured with NIH 3T3 in the alginate/galactosylated chitosan scaffold. , 2006, Biomaterials.

[42]  J. Sacci,et al.  Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers. , 2006, International journal for parasitology.

[43]  L. Samson,et al.  A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction. , 2005, Current drug metabolism.

[44]  D. Kohane,et al.  Engineering vascularized skeletal muscle tissue , 2005, Nature Biotechnology.

[45]  T. Roskams,et al.  Morphological and biochemical characterization of a human liver in a uPA‐SCID mouse chimera , 2005, Hepatology.

[46]  David J Mooney,et al.  Locally enhanced angiogenesis promotes transplanted cell survival. , 2004, Tissue engineering.

[47]  H. Shimizu,et al.  Macrophage Migration Inhibitory Factor Is Induced by Thrombin and Factor Xa in Endothelial Cells* , 2004, Journal of Biological Chemistry.

[48]  Masao Yuda,et al.  Cell-Passage Activity Is Required for the Malarial Parasite to Cross the Liver Sinusoidal Cell Layer , 2004, PLoS biology.

[49]  Simona Corso,et al.  Hepatocyte growth factor and its receptor are required for malaria infection , 2003, Nature Medicine.

[50]  Kenneth J. Hillan,et al.  Angiogenesis-Independent Endothelial Protection of Liver: Role of VEGFR-1 , 2003, Science.

[51]  Jonathan E. Allen,et al.  Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii , 2002, Nature.

[52]  L. Griffith,et al.  A microfabricated array bioreactor for perfused 3D liver culture. , 2002, Biotechnology and bioengineering.

[53]  Wei-Shou Hu,et al.  Structural polarity and functional bile canaliculi in rat hepatocyte spheroids. , 2002, Experimental cell research.

[54]  D. Mooney,et al.  Polymeric system for dual growth factor delivery , 2001, Nature Biotechnology.

[55]  J. Vacanti,et al.  Silicon micromachining to tissue engineer branched vascular channels for liver fabrication. , 2000, Tissue engineering.

[56]  M L Yarmush,et al.  Effect of cell–cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[57]  J. Hubbell,et al.  Characterization of permeability and network structure of interfacially photopolymerized poly(ethylene glycol) diacrylate hydrogels. , 1998, Biomaterials.

[58]  J. Nishihira,et al.  Identification of macrophage migration inhibitory factor (MIF) in human vascular endothelial cells and its induction by lipopolysaccharide. , 1998, Cytokine.

[59]  L G Griffith,et al.  In Vitro Organogenesis of Liver Tissue a , 1997, Annals of the New York Academy of Sciences.

[60]  A. Moreno,et al.  In vitro development of infectious liver stages of P. yoelii and P. berghei malaria in human cell lines. , 1994, Experimental parasitology.

[61]  N. Marceau,et al.  Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities , 1985, The Journal of cell biology.

[62]  D. Mazier,et al.  Complete development of hepatic stages of Plasmodium falciparum in vitro. , 1985, Science.

[63]  M. Hollingdale,et al.  In vitro cultivation of the exoerythrocytic stage of Plasmodium berghei in a hepatoma cell line. , 1983, The American journal of tropical medicine and hygiene.

[64]  M. Hollingdale,et al.  In vitro cultivation of the exoerythrocytic stage of Plasmodium berghei from sporozoites. , 1981, Science.

[65]  A. Kleinman,et al.  Primaquine Failure and Cytochrome P-450 2D6 in Plasmodium vivax Malaria , 2013 .

[66]  S. Varghese,et al.  Poly(ethylene glycol) cryogels as potential cell scaffolds: effect of polymerization conditions on cryogel microstructure and properties , 2010 .

[67]  S. Bhatia,et al.  Microscale culture of human liver cells for drug development , 2008, Nature Biotechnology.

[68]  Weltgesundheitsorganisation World malaria report , 2005 .

[69]  D. Waxman,et al.  Long-term enhancement of cytochrome P450 2B1/2 expression in rat hepatocyte spheroids through adenovirus-mediated gene transfer , 2004, Cell Biology and Toxicology.

[70]  S. Levy,et al.  Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity , 2003, Nature Medicine.

[71]  C. Guguen-Guillouzo,et al.  Cultivation of the liver forms of Plasmodium vivax in human hepatocytes , 1984, Nature.