Lead toxicity: a review

Abstract Lead toxicity is an important environmental disease and its effects on the human body are devastating. There is almost no function in the human body which is not affected by lead toxicity. Though in countries like US and Canada the use of lead has been controlled up to a certain extent, it is still used vehemently in the developing countries. This is primarily because lead bears unique physical and chemical properties that make it suitable for a large number of applications for which humans have exploited its benefits from historical times and thus it has become a common environmental pollutant. Lead is highly persistent in the environment and because of its continuous use its levels rise in almost every country, posing serious threats. This article reviews the works listed in the literature with recent updates regarding the toxicity of lead. Focus is also on toxic effects of lead on the renal, reproductive and nervous system. Finally the techniques available for treating lead toxicity are presented with some recent updates.

[1]  J. Chisolm,et al.  The exposure of children to lead. , 1956, Pediatrics.

[2]  Dr. B. K. B. Berkovitz,et al.  Teeth , 1860, Handbook of Microscopic Anatomy.

[3]  P. Roberson,et al.  Reproductive toxicity and growth effects in rats exposed to lead at different periods during development. , 1996, Toxicology and applied pharmacology.

[4]  J. Lin,et al.  Body lead stores and urate excretion in men with chronic renal disease. , 1994, The Journal of rheumatology.

[5]  Michigan.,et al.  Toxicological profile for dichloropropenes , 2008 .

[6]  Brian S. Schwartz,et al.  The Epidemiology of Lead Toxicity in Adults: Measuring Dose and Consideration of Other Methodologic Issues , 2006, Environmental health perspectives.

[7]  Rutao Liu,et al.  Binding mode investigations on the interaction of lead(II) acetate with human chorionic gonadotropin. , 2014, The journal of physical chemistry. B.

[8]  F. Mai.  Beethoven's terminal illness and death. , 2006, The journal of the Royal College of Physicians of Edinburgh.

[9]  A. Merklen,et al.  [Lead poisoning]. , 1956, Revue medicale de Nancy.

[10]  Derek R. Smith,et al.  How does lead induce male infertility? , 2011, Iranian journal of reproductive medicine.

[11]  N. Mañay,et al.  Lead contamination in Uruguay: the "La Teja" neighborhood case. , 2008, Reviews of environmental contamination and toxicology.

[12]  Brian S. Schwartz,et al.  Recommendations for Medical Management of Adult Lead Exposure , 2006, Environmental health perspectives.

[13]  Warren Friedman,et al.  The prevalence of lead-based paint hazards in U.S. housing. , 2002, Environmental health perspectives.

[14]  E. Guallar,et al.  Lead Exposure and Cardiovascular Disease—A Systematic Review , 2006, Environmental health perspectives.

[15]  A. Woolf,et al.  Update on the clinical management of childhood lead poisoning. , 2007, Pediatric clinics of North America.

[16]  A. Bennett,et al.  Occupational lead poisoning. , 1998, American family physician.

[17]  J. Ouyang,et al.  Dysplastic changes in erythroid precursors as a manifestation of lead poisoning: report of a case and review of literature. , 2015, International journal of clinical and experimental pathology.

[18]  M. R. Moore.  Lead in drinking water in soft water areas--health hazards. , 1977, The Science of the total environment.

[19]  R. Nevin.  Understanding international crime trends: the legacy of preschool lead exposure. , 2007, Environmental research.

[20]  D. Cory-Slechta,et al.  New and Evolving Concepts in the Neurotoxicology of Lead , 2007 .

[21]  K. Hsu,et al.  Environmental lead exposure and progression of chronic renal diseases in patients without diabetes. , 2003, The New England journal of medicine.

[22]  R. Wedeen,et al.  Occupational lead nephropathy. , 1975, The American journal of medicine.

[23]  H. Haas,et al.  Blockade of mammalian and invertebrate calcium channels by lead. , 1993, Neurotoxicology.

[24]  Zhi Pan,et al.  Puerarin induces the upregulation of glutathione levels and nuclear translocation of Nrf2 through PI3K/Akt/GSK-3β signaling events in PC12 cells exposed to lead. , 2014, Neurotoxicology and teratology.

[25]  Jason A Inzana,et al.  Effects of Combined Exposure to Lead and High-Fat Diet on Bone Quality in Juvenile Male Mice , 2015, Environmental health perspectives.

[26]  Ashish Mehta,et al.  Heavy metal induced oxidative stress & its possible reversal by chelation therapy. , 2008, The Indian journal of medical research.

[27]  C Waternaux,et al.  Longitudinal analyses of prenatal and postnatal lead exposure and early cognitive development. , 1987, The New England journal of medicine.

[28]  J. Pearce.  Burton’s Line in Lead Poisoning , 2006, European Neurology.

[29]  J. Turnbull.  Lead on. , 1994, Nursing times.

[30]  J. Kasperczyk,et al.  THE INFLUENCE OF β-CAROTENE ON HOMOCYSTEINE LEVEL AND OXIDATIVE STRESS IN LEAD-EXPOSED WORKERS , 2014 .

[31]  Ja‐Liang Lin,et al.  Environmental exposure to lead and progression of chronic renal diseases: a four-year prospective longitudinal study. , 2004, Journal of the American Society of Nephrology : JASN.

[32]  Chun-Hsun Huang,et al.  Evaluation of the hepatotoxic risk caused by lead acetate via skin exposure using a proteomic approach , 2014, Proteomics.

[33]  S. Porru,et al.  Male reproductive toxicity of lead in animals and humans. ASCLEPIOS Study Group. , 1998, Occupational and environmental medicine.

[34]  A. Kasperczyk,et al.  Effect of N-acetylcysteine administration on homocysteine level, oxidative damage to proteins, and levels of iron (Fe) and Fe-related proteins in lead-exposed workers , 2016, Toxicology and industrial health.

[35]  C. Nishitani,et al.  Lead, chemical porphyria, and heme as a biological mediator. , 2002, The Tohoku journal of experimental medicine.

[36]  T. Clarkson,et al.  Toxic effects of metals , 2001 .

[37]  M. Shannon.  Severe lead poisoning in pregnancy. , 2003, Ambulatory pediatrics : the official journal of the Ambulatory Pediatric Association.

[38]  Jonathan Watts.  Lead poisoning cases spark riots in China , 2009, The Lancet.

[39]  J. Timbrell,et al.  Casarett and Doull's Toxicology: The Basic Science of Poisons , 1981 .

[40]  B. Schwartz,et al.  Cumulative Lead Dose and Cognitive Function in Adults: A Review of Studies That Measured Both Blood Lead and Bone Lead , 2006, Environmental health perspectives.

[41]  A. Cohen,et al.  Reassessment of the microcytic anemia of lead poisoning. , 1981, Pediatrics.

[42]  Monica Campbell,et al.  Identifying and managing adverse environmental health effects: 3. Lead exposure. , 2002, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[43]  Michael R. Schock,et al.  Lead Exposures in U.S. Children, 2008: Implications for Prevention , 2008, Environmental health perspectives.

[44]  Enrico Rossi,et al.  Low level environmental lead exposure--a continuing challenge. , 2008, The Clinical biochemist. Reviews.

[45]  Wright Lf,et al.  Occult Lead Intoxication in Patients With Gout and Kidney Disease , 1984 .

[46]  T. Erickson.  Pediatric Toxicology: Diagnosis and Management of the Poisoned Child , 2004 .

[47]  B. Jaar,et al.  Lead-related nephrotoxicity: a review of the epidemiologic evidence. , 2006, Kidney international.

[48]  D. Bellinger,et al.  Very low lead exposures and children's neurodevelopment , 2008, Current opinion in pediatrics.

[49]  Paul B Tchounwou,et al.  Neurotoxic Effects and Biomarkers of Lead Exposure: A Review , 2009, Reviews on environmental health.

[50]  R. Sokol.  Reversibility of the toxic effect of lead on the male reproductive axis. , 1989, Reproductive toxicology.

[51]  L. Patrick.  Lead toxicity, a review of the literature. Part 1: Exposure, evaluation, and treatment. , 2006, Alternative medicine review : a journal of clinical therapeutic.

[52]  R. Barkin.  Disposition of Toxic Drugs and Chemicals in Man, 8th ed , 2009 .

[53]  L. Fuortes,et al.  A cluster of lead poisoning among consumers of Ayurvedic medicine , 2015, International journal of occupational and environmental health.

[54]  D. Bellinger.  Teratogen update: lead and pregnancy. , 2005, Birth defects research. Part A, Clinical and molecular teratology.

[55]  N. Berman,et al.  The effect of age of exposure on lead-induced testicular toxicity. , 1991, Toxicology.

[56]  S. Kales,et al.  Lead encephalopathy due to traditional medicines. , 2008, Current drug safety.

[57]  A. Tiwari,et al.  Toxicity of lead: A review with recent updates , 2012, Interdisciplinary toxicology.

[58]  Robert L. Jones,et al.  The effect of chelation therapy with succimer on neuropsychological development in children exposed to lead. , 2001, The New England journal of medicine.

[59]  C. Sobin,et al.  Early chronic lead exposure reduces exploratory activity in young C57BL/6J mice , 2015, Journal of applied toxicology : JAT.

[60]  Lisa H. Mason,et al.  Pb Neurotoxicity: Neuropsychological Effects of Lead Toxicity , 2014, BioMed research international.

[61]  M. Kurti,et al.  Investigation of lead and cadmium in counterfeit cigarettes seized in the United States. , 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[62]  D Bellinger,et al.  The long-term effects of exposure to low doses of lead in childhood. An 11-year follow-up report. , 1990, The New England journal of medicine.

[63]  P. Gać,et al.  Function of respiratory system evaluated using selected spirometry parameters in persons occupationally exposed to lead without evident health problems. , 2015, Environmental toxicology and pharmacology.

[64]  J. Tanus-Santos,et al.  A Critical Review of Biomarkers Used for Monitoring Human Exposure to Lead: Advantages, Limitations, and Future Needs , 2005, Environmental health perspectives.

[65]  G. Pinon-Lataillade,et al.  Impairment of testicular endocrine function after lead intoxication in the adult rat. , 1995, Toxicology.

[66]  Elena I. Queirolo,et al.  Association of blood lead levels with urinary F₂-8α isoprostane and 8-hydroxy-2-deoxy-guanosine concentrations in first-grade Uruguayan children. , 2015, Environmental research.

[67]  K R Mahaffey,et al.  Environmental lead toxicity: nutrition as a component of intervention. , 1990, Environmental health perspectives.

[68]  Ying Tian,et al.  Effects of lead exposure on hippocampal metabotropic glutamate receptor subtype 3 and 7 in developmental rats , 2009, Journal of Negative Results in BioMedicine.

[69]  D. Barceloux,et al.  Disposition of Toxic Drugs and Chemicals in Man , 2015 .

[70]  Kathryn R. Mahaffey,et al.  Lead and compounds. , 2000 .

[71]  Philip J Landrigan,et al.  Environmental pollutants and disease in American children: estimates of morbidity, mortality, and costs for lead poisoning, asthma, cancer, and developmental disabilities. , 2002, Environmental health perspectives.

[72]  G. Ahmad,et al.  Effects of lead on the male reproductive system in mice. , 1999, Journal of toxicology and environmental health. Part A.

[73]  M. Mcgeehin,et al.  A global approach to childhood lead poisoning prevention. , 2003, International journal of hygiene and environmental health.

[74]  G. Schoeters,et al.  Endocrine disruptors and abnormalities of pubertal development. , 2008, Basic & clinical pharmacology & toxicology.

[75]  Joel Schwartz,et al.  Air Pollution and Heart Rate Variability: Effect Modification by Chronic Lead Exposure , 2008, Epidemiology.

[76]  A. A. Scott,et al.  Lead hazards for pregnant women and children: part 2: more can still be done to reduce the chance of exposure to lead in at-risk populations. , 2008, The American journal of nursing.

[77]  R. Nevin.  How lead exposure relates to temporal changes in IQ, violent crime, and unwed pregnancy. , 2000, Environmental research.

[78]  F. Cecere,et al.  Occult lead intoxication in patients with gout and kidney disease. , 1984, The Journal of rheumatology.

[79]  Indran Amirthanayagam,et al.  Lead , 2006, Pediatric Environmental Health.

[80]  Lynn L. Bergeson,et al.  The proposed lead NAAQS: Is consideration of cost in the clean air act's future? , 2008 .

[81]  P. Landrigan,et al.  A case report of lead paint poisoning during renovation of a Victorian farmhouse. , 1990, American journal of public health.

[82]  J. McCulloch,et al.  CHAPTER 7 – Implications for Prevention , 1972 .