论文信息 - Serum Mutant K‐ras in the Colorectal Adenoma‐to‐Carcinoma Sequence: Implications for Diagnosis, Postoperative Follow‐up, and Early Detection of Recurrent Disease

Serum Mutant K‐ras in the Colorectal Adenoma‐to‐Carcinoma Sequence: Implications for Diagnosis, Postoperative Follow‐up, and Early Detection of Recurrent Disease

The aim of this study is to detect mutant K-ras in the plasma/serum of patients with colorectal adenomata and carcinomas, and to correlate this with the presence or absence of K-ras mutation in the primary tumor. In addition, we intend to investigate the prevalence of mutant K-ras in the serum of the postresection patient and to investigate if postoperative appearance or persistence of mutant DNA in the serum correlates with disease recurrence.

[1] V. Vasioukhin,et al. K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer. , 1997, Gastroenterology.

[2] D. Swinkels,et al. Detection of tumour DNA in serum of colorectal cancer patients. , 1997, Scandinavian journal of clinical and laboratory investigation.

[3] F. A. Benko,et al. Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer. , 1997, British Journal of Cancer.

[4] B. Vogelstein,et al. Prevalence of ras gene mutations in human colorectal cancers , 1987, Nature.