论文信息 - The interaction of antibiotics with synthetic steroids in the rat [proceedings].

The interaction of antibiotics with synthetic steroids in the rat [proceedings].

this level in vitro produced 77 + 3% inhibition of DNA synthesis. The duration of greater than 50% inhibition of DNA synthesis in vivo would be expected to be 5 h based on plasma Ara-C levels. However, based on intracellular Ara-CTP levels, DNA synthesis would be inhibited by more than 50%o for 11 h, at which time plasma Ara-C would be expected to have no effect on DNA synthesis. It is apparent when considering dosage schedules of Ara-C in the treatment of leukaemia, the cellular pharmacokinetics and pharmacodynamics of Ara-CTP may be more important determinants than plasma Ara-C levels. References

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