Synthesis and screening of potential antimalarial agent alpha-(2-piperidyl)-2-(1-adamantyl)-6,8-dichloro-4-quinolinemethanol hydrochloride.

The synthesis and biological testing of α-(2-piperidyl)-2-(1-adamantyl)-6,8-dichloro-4-quinolinemethanol hydrochloride and its O-acetyl and N-acetyl derivatives are reported. Direct hydrogenation of the α-pyridyl ketone gave very low yields. A novel procedure was developed which permits formation of piperidyl quinolinemethanols in satisfactory yields.

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