The influence of commonly prescribed synthetic drugs for peptic ulcer on the pharmacokinetic fate of glycyrrhizin from Shaoyao-Gancao-tang.

The influence of synthetic drugs prescribed for peptic ulcer on the pharmacokinetic fate of glycyrrhizin (GL) from Shaoyao-Gancao-tang (SGT, a traditional Chinese formulation, Shakuyaku-Kanzo-to in Japanese) was investigated in rats. Co-administration of histamine H2-receptor antagonist (cimetidine) and anticholinergic drug (scopolamine butyl bromide) with SGT didn't influence the area under the plasma concentration-time curves (AUC) of glycyrrhetic acid (GA), an active metabolite derived from GL in SGT. The AUC of GA from SGT were significantly reduced by co-administration of synthetic drugs commonly used for peptic ulcer in a triple therapy (OAM), a combination of a proton pump inhibitor (omeprazole) and two antibiotics (amoxicillin and metronidazole). We found that the reduction of AUC in OAM treatment was due to the antibacterial effect of amoxicillin and metronidazole on intestinal bacteria in rat which lead to the decrease of GL-hydrolysis activity. The present study suggests that it may not be a proper way to use triple therapy containing antibiotics simultaneously with SGT for healing of chronic ulcers.

[1]  A. Olukoga,et al.  Liquorice and its health implications , 2000, The journal of the Royal Society for the Promotion of Health.

[2]  C. Nord,et al.  Microbial Ecology and Treatment of Helicobacter pylori Infections: Review , 2000, Journal of chemotherapy.

[3]  N. Nishimura,et al.  A Chinese traditional medicine, sho-saiko-to (xiao-chaihu-tang), reduces the bioavailability of tolbutamide after oral administration in rats. , 1999, The American journal of Chinese medicine.

[4]  J. Chung.  Inhibitory actions of glycyrrhizic acid on arylamine N-acetyltransferase activity in strains of Helicobacter pylori from peptic ulcer patients. , 1998, Drug and chemical toxicology.

[5]  Soll Ah.  Consensus conference. Medical treatment of peptic ulcer disease. Practice guidelines. Practice Parameters Committee of the American College of Gastroenterology. , 1996 .

[6]  L. Imamura.  Inhibition of urease and growth of Helicobacter pylori by herb extracts , 1995 .

[7]  K. Kobashi,et al.  Intestinal bacterial hydrolysis is indispensable to absorption of 18β‐glycyrrhetic acid after oral administration of glycyrrhizin in rats , 1994, The Journal of pharmacy and pharmacology.

[8]  D. An,et al.  Determination of glycyrrhizin and its metabolite glycyrrhetinic acid in rabbit plasma by high-performance liquid chromatography after oral administration of licorzin. , 1989, Journal of chromatography.

[9]  K. Kobashi,et al.  Glycyrrhizin β-D-Glucuronidase of Eubacterium sp. from Human Intestinal Flora , 1987 .

[10]  K. Wormsley,et al.  Adverse Reactions and Interactions with H2-Receptor Antagonists , 1986, Medical toxicology.

[11]  S. Amagaya,et al.  Studies on the combination of Glycyrrhizae Radix in Shakuyakukanzo-To. , 1984, Journal of Pharmacobio-Dynamics.

[12]  H. Bergmann,et al.  Effects of oral cyclotropium bromide, hyoscine N-butylbromide and placebo on gastric emptying and antral motor activity in healthy man. , 1984, Gut.

[13]  S. Okabe,et al.  A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing. , 1969, Japanese journal of pharmacology.