A Resource-Optimized VLSI Implementation of a Patient-Specific Seizure Detection Algorithm on a Custom-Made 2.2 cm$^2$ Wireless Device for Ambulatory Epilepsy Diagnostics

A patient-specific epilepsy diagnostic solution in the form of a wireless wearable ambulatory device is presented. First, the design, VLSI implementation, and experimental validation of a resource-optimized machine learning algorithm for epilepsy seizure detection are described. Next, the development of a mini-PCB that integrates a low-power wireless data transceiver and a programmable processor for hosting the seizure detection algorithm is discussed. The algorithm uses only EEG signals from the frontal lobe electrodes while yielding a seizure detection sensitivity and specificity competitive to the standard full EEG systems. The experimental validation of the algorithm VLSI implementation proves the possibility of conducting accurate seizure detection using quickly-mountable dry-electrode headsets without the need for uncomfortable/painful through-hair electrodes or adhesive gels. Details of design and optimization of the algorithm, the VLSI implementation, and the mini-PCB development are presented and resource optimization techniques are discussed. The optimized implementation is uploaded on a low-power Microsemi Igloo FPGA, requires 1237 logic elements, consumes 110 $\mu$W dynamic power, and yields a minimum detection latency of 10.2 $\mu$s. The measurement results from the FPGA implementation on data from 23 patients (198 seizures in total) shows a seizure detection sensitivity and specificity of 92.5% and 80.1%, respectively. Comparison to the state of the art is presented from system integration, the VLSI implementation, and the wireless communication perspectives.