Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective

[1]  J. Schwartz,et al.  Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease , 2004, Molecular Psychiatry.

[2]  Matthew P. Frosch,et al.  The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease , 2004, Neuron.

[3]  R. Tanzi,et al.  Clearance of Alzheimer's Aβ Peptide The Many Roads to Perdition , 2004, Neuron.

[4]  M. Citron,et al.  Strategies for disease modification in Alzheimer's disease , 2004, Nature Reviews Neuroscience.

[5]  Peter J. Lenting,et al.  LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms , 2004, Neuron.

[6]  D. Lahiri,et al.  Metal and inflammatory targets for Alzheimer's disease. , 2004, Current drug targets.

[7]  S. Duan,et al.  Insulin-degrading enzyme and Alzheimer disease , 2004, Neurology.

[8]  H. Soininen,et al.  Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population , 2004, Neurology.

[9]  C. van Broeckhoven,et al.  A novel presenilin 1 mutation associated with Pick's disease but not β‐amyloid plaques , 2004, Annals of neurology.

[10]  B. Zlokovic Clearing amyloid through the blood–brain barrier , 2004, Journal of neurochemistry.

[11]  Xi Chen,et al.  Materials and Methods Som Text Figs. S1 and S2 Table S1 References Abad Directly Links A␤ to Mitochondrial Toxicity in Alzheimer's Disease , 2022 .

[12]  K. Blennow,et al.  Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease , 2004, Neurogenetics.

[13]  E. Kandel,et al.  Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration , 2004, Neuron.

[14]  R. Tanzi,et al.  Alzheimer's disease: one disorder, too many genes? , 2004, Human molecular genetics.

[15]  R. Petersen,et al.  Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Aβ42 levels and risk for Alzheimer disease , 2004, Human mutation.

[16]  D. Selkoe,et al.  Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. , 2004, The American journal of pathology.

[17]  Mitsutoshi Yamamoto,et al.  Association of the Neprilysin Gene with Susceptibility to Late-Onset Alzheimer’s Disease , 2004, Dementia and Geriatric Cognitive Disorders.

[18]  Mitsutoshi Yamamoto,et al.  No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population , 2004, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[19]  D. Blacker,et al.  PEN2 is not a genetic risk factor for Alzheimer’s disease in a large family sample , 2004, Neurology.

[20]  Bruce J Aronow,et al.  ApoE and Clusterin Cooperatively Suppress Aβ Levels and Deposition Evidence that ApoE Regulates Extracellular Aβ Metabolism In Vivo , 2004, Neuron.

[21]  D. Selkoe,et al.  Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death , 2003, Neuron.

[22]  M. Franceschi,et al.  Nicastrin gene in familial and sporadic Alzheimer's disease , 2003, Neuroscience Letters.

[23]  A. Mackinnon,et al.  Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. , 2003, Archives of neurology.

[24]  P. Lansbury,et al.  Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. , 2003, Annual review of neuroscience.

[25]  J. Herz LRP: a bright beacon at the blood-brain barrier. , 2003, The Journal of clinical investigation.

[26]  M. Daly,et al.  Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. , 2003, Human molecular genetics.

[27]  J. Gilbert,et al.  Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22. , 2003, American journal of human genetics.

[28]  L. Feuk,et al.  Genetic variation in a haplotype block spanning IDE influences Alzheimer disease , 2003, Human mutation.

[29]  A. Padovani,et al.  Association analysis between anterior-pharynx defective-1 genes polymorphisms and Alzheimer's disease , 2003, Neuroscience Letters.

[30]  C. Masters,et al.  Copper, β-amyloid, and Alzheimer's disease: Tapping a sensitive connection , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[31]  S. Weggen,et al.  Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid β42 Production by Direct Modulation of γ-Secretase Activity* , 2003, Journal of Biological Chemistry.

[32]  Jaume Bertranpetit,et al.  Possible increased risk for Alzheimer's disease associated with neprilysin gene , 2003, Journal of Neural Transmission.

[33]  S. Antonarakis,et al.  Specific BACE1 genotypes provide additional risk for late‐onset alzheimer disease in APOE ε4 carriers , 2003, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[34]  L. Hersh,et al.  Amyloid-β peptide levels in brain are inversely correlated with insulysin activity levels in vivo , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[35]  J. Regula,et al.  Reconstitution of γ-secretase activity , 2003, Nature Cell Biology.

[36]  C. van Broeckhoven,et al.  Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expression. , 2003, Human molecular genetics.

[37]  Matthew P. Frosch,et al.  Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[38]  Doo Yeon Kim,et al.  Nectin-1α, an Immunoglobulin-like Receptor Involved in the Formation of Synapses, Is a Substrate for Presenilin/γ-Secretase-like Cleavage* , 2002, The Journal of Biological Chemistry.

[39]  E. Masliah,et al.  Increased Extracellular Amyloid Deposition and Neurodegeneration in Human Amyloid Precursor Protein Transgenic Mice Deficient in Receptor-Associated Protein , 2002, The Journal of Neuroscience.

[40]  B. Tycko,et al.  Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease. , 2002, Archives of neurology.

[41]  D. Campion,et al.  Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease , 2002, Neuroscience Letters.

[42]  Rustam Azimov,et al.  The channel hypothesis of Alzheimer’s disease: current status , 2002, Peptides.

[43]  Wei Xu,et al.  aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation , 2002 .

[44]  P. S. St George-Hyslop,et al.  The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample. , 2002, American journal of human genetics.

[45]  C. Haass,et al.  Insulin-degrading Enzyme Rapidly Removes the β-Amyloid Precursor Protein Intracellular Domain (AICD)* , 2002, The Journal of Biological Chemistry.

[46]  Rajesh Pahwa,et al.  Age at onset in two common neurodegenerative diseases is genetically controlled. , 2002, American journal of human genetics.

[47]  A. LeBlanc,et al.  Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons , 2002, The Journal of cell biology.

[48]  D. Easton,et al.  Genome-wide linkage disequilibrium mapping of late-onset Alzheimer’s disease in Finland , 2001, Neurology.

[49]  D. Selkoe Clearing the Brain's Amyloid Cobwebs , 2001, Neuron.

[50]  M. Owen,et al.  Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease , 2001, Human Genetics.

[51]  K. Goddard,et al.  The amyloid precursor protein locus and very-late-onset Alzheimer disease. , 2001, American journal of human genetics.

[52]  You-Qiang Song,et al.  Screening for PS1 mutations in a referral-based series of AD cases , 2001, Neurology.

[53]  G. Landreth,et al.  Microglial interaction with β‐amyloid: Implications for the pathogenesis of Alzheimer's disease , 2001 .

[54]  Thomas C. Südhof,et al.  A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60 , 2001, Science.

[55]  J. Morris,et al.  Association studies using novel polymorphisms in BACE1 and BACE2 , 2001, Neuroreport.

[56]  D. Mann,et al.  The −48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Aβ load in brain , 2001, Journal of medical genetics.

[57]  J. Blangero,et al.  Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. , 2000, Science.

[58]  M. Owen,et al.  Susceptibility locus for Alzheimer's disease on chromosome 10. , 2000, Science.

[59]  M G McInnis,et al.  Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. , 2000, Science.

[60]  D. Holtzman,et al.  Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. , 2000, The Journal of clinical investigation.

[61]  M. McInnis,et al.  Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies , 2000, Experimental Gerontology.

[62]  G. Rebeck Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer's disease , 2000, Neuroscience Letters.

[63]  H. Soininen,et al.  Genome-wide linkage disequilibrium mapping of late onset Alzheimer's disease in Finland , 2000, Neurobiology of Aging.

[64]  M. Franceschi,et al.  Association of early‐onset Alzheimer's disease with an interleukin‐1α gene polymorphism , 2000, Annals of neurology.

[65]  B. Strooper,et al.  Alzheimer's disease: A firm base for drug development , 1999, Nature.

[66]  Rudolph E. Tanzi,et al.  BACE Maps to Chromosome 11 and a BACE Homolog, BACE2, Reside in the Obligate Down Syndrome Region of Chromosome 21 , 1999 .

[67]  J. Treanor,et al.  Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. , 1999, Science.

[68]  F. Jessen,et al.  A genetic variation of the inflammatory cytokine interleukin‐6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease , 1999, Annals of neurology.

[69]  D. Selkoe,et al.  Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity , 1999, Nature.

[70]  M. Owen,et al.  A full genome scan for late onset Alzheimer's disease , 1999 .

[71]  L. Harrell,et al.  Polymorphic tetranucleotide repeat site within intron 7 of the β-amyloid precursor protein gene and its lack of association with Alzheimer’s disease , 1998, Human Genetics.

[72]  K. Welsh-Bohmer,et al.  APOE genotype predicts when — not whether — one is predisposed to develop Alzheimer disease , 1998, Nature Genetics.

[73]  Bruce A. Yankner,et al.  Aging renders the brain vulnerable to amyloid β-protein neurotoxicity , 1998, Nature Medicine.

[74]  Hugo Vanderstichele,et al.  Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein , 1998, Nature.

[75]  C. L. Harris,et al.  Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors* , 1997, The Journal of Biological Chemistry.

[76]  J. Haines,et al.  Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. , 1997, JAMA.

[77]  J. Haines,et al.  Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis , 1997 .

[78]  S. Ralston,et al.  Polymorphisms of the interleukin-6 gene are associated with bone mineral density , 1997, Osteoporosis International.

[79]  J. Haines,et al.  ApoE-4 and Age at Onset of Alzheimer's Disease , 1997, Neurology.

[80]  G. Schellenberg,et al.  Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease , 1996, Nature Medicine.

[81]  A. Goate,et al.  Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease , 1996, The Lancet.

[82]  J. Rommens,et al.  Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene , 1995, Nature.

[83]  G. Schellenberg,et al.  Candidate gene for the chromosome 1 familial Alzheimer's disease locus , 1995, Science.

[84]  D. Pollen,et al.  Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease , 1995, Nature.

[85]  A D Roses,et al.  Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[86]  P. Lansbury,et al.  The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. , 1993, Biochemistry.

[87]  M. Pericak-Vance,et al.  Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[88]  M. Pericak-Vance,et al.  Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. , 1991, American journal of human genetics.

[89]  M. Pericak-Vance,et al.  Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease , 1991, Nature.

[90]  J. Hardy,et al.  Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch). , 1990, Science.

[91]  I. Lieberburg,et al.  Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. , 1990, Science.

[92]  H. Wiśniewski,et al.  Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[93]  M. Lerman,et al.  Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. , 1987, Science.

[94]  D. Pollen,et al.  The genetic defect causing familial Alzheimer's disease maps on chromosome 21. , 1987, Science.

[95]  P. S. St George-Hyslop,et al.  Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. , 1987, Science.

[96]  C. Masters,et al.  Amyloid plaque core protein in Alzheimer disease and Down syndrome. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[97]  G. Glenner,et al.  Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. , 1984, Biochemical and biophysical research communications.

[98]  V. Anderson,et al.  Dementia of the Alzheimer Type: Clinical Genetics, Natural History, and Associated Conditions , 1981 .

[99]  S. Guénette Mechanisms of Aβ clearance and catabolism , 2007, NeuroMolecular Medicine.

[100]  R. Tanzi,et al.  Clearance of Alzheimer's Abeta peptide: the many roads to perdition. , 2004, Neuron.

[101]  R. Deane,et al.  LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. , 2004, Neuron.

[102]  C. Masters,et al.  Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection. , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[103]  D. Selkoe,et al.  Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[104]  J. Regula,et al.  Reconstitution of gamma-secretase activity. , 2003, Nature cell biology.

[105]  S. Guénette Mechanisms of Abeta clearance and catabolism. , 2003, Neuromolecular medicine.

[106]  S. Weggen,et al.  Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. , 2003, The Journal of biological chemistry.

[107]  M. Albert,et al.  Results of a high-resolution genome screen of 437 Alzheimer's disease families. , 2003, Human molecular genetics.

[108]  M. C. Ellis,et al.  aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. , 2002, Developmental cell.

[109]  L. Hersh,et al.  Regulation of amyloid beta-peptide levels by enzymatic degradation. , 2002, Journal of Alzheimer's disease : JAD.

[110]  L. Hersh,et al.  Regulation of amyloid β-peptide levels by enzymatic degradation , 2002 .

[111]  T. Südhof,et al.  A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. , 2001, Science.

[112]  E M Wijsman,et al.  The number of trait loci in late-onset Alzheimer disease. , 2000, American journal of human genetics.

[113]  C. Geula,et al.  Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. , 1998, Nature medicine.

[114]  D L Price,et al.  Alzheimer's disease: genetic studies and transgenic models. , 1998, Annual review of genetics.

[115]  J. Hardy,et al.  Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. , 1996, Nature medicine.

[116]  M. Hutton,et al.  Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group. , 1996, Lancet.

[117]  M. Lerman,et al.  Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimerʼs disease , 1988 .

[118]  K. Grzeschik,et al.  The precursor of Alzheimer??s disease amyloid A4 protein resembles a cell-surface receptor , 1987 .

[119]  A. Alzheimer Uber eine eigenartige Erkrankung der Hirnrinde , 1907 .