Memory CD4+ T Lymphocytes in the Gastrointestinal Tract Are a Major Source of Cell-Associated Simian Immunodeficiency Virus in Chronic Nonpathogenic Infection of African Green Monkeys

ABSTRACT Simian immunodeficiency virus (SIV) infection of natural hosts is characterized by nonpathogenic chronic viremia, maintenance of gastrointestinal epithelial barrier integrity, and low numbers of target cells. Assessment of cell-associated virus load in T cell subsets in multiple anatomic compartments of chronically SIV-infected sabeus African green monkeys (AGMs) revealed that gastrointestinal memory CD4+ T lymphocytes are a major source of cell-associated virus and a significant contributor to SIV viremia in AGMs.

[1]  M. Seaman,et al.  High Cell-Free Virus Load and Robust Autologous Humoral Immune Responses in Breast Milk of Simian Immunodeficiency Virus-Infected African Green Monkeys , 2011, Journal of Virology.

[2]  Brigitte E. Sanders-Beer,et al.  CD4-Like Immunological Function by CD4− T Cells in Multiple Natural Hosts of Simian Immunodeficiency Virus , 2011, Journal of Virology.

[3]  J. Brenchley,et al.  Low levels of SIV infection in sooty mangabey central-memory CD4+ T-cells is associated with limited CCR5 expression , 2011, Nature Medicine.

[4]  J. Brenchley,et al.  Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells. , 2011, The Journal of clinical investigation.

[5]  S. Pittaluga,et al.  Damaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections , 2010, PLoS pathogens.

[6]  D. Montefiori,et al.  Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease. , 2010, Blood.

[7]  J. Brenchley,et al.  Down-regulation of CD4 by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection , 2009, Nature Medicine.

[8]  Aarti Gautam,et al.  Cutting Edge: Experimentally Induced Immune Activation in Natural Hosts of Simian Immunodeficiency Virus Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion1 , 2008, The Journal of Immunology.

[9]  G. Freeman,et al.  Simian Immunodeficiency Virus (SIV)-Specific CD8+ T-Cell Responses in Vervet African Green Monkeys Chronically Infected with SIVagm , 2008, Journal of Virology.

[10]  D. Douek,et al.  Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. , 2008, Blood.

[11]  A. Haase,et al.  Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys. , 2008, The Journal of clinical investigation.

[12]  A. Perelson,et al.  Simian Immunodeficiency Virus SIVagm Dynamics in African Green Monkeys , 2008, Journal of Virology.

[13]  S. Staprans,et al.  Severe Depletion of Mucosal CD4+ T Cells in AIDS-Free Simian Immunodeficiency Virus-Infected Sooty Mangabeys1 , 2007, The Journal of Immunology.

[14]  S. Staprans,et al.  Virally Induced CD4+ T Cell Depletion Is Not Sufficient to Induce AIDS in a Natural Host1 , 2007, The Journal of Immunology.

[15]  A. Perelson,et al.  Acute Loss of Intestinal CD4+ T Cells Is Not Predictive of Simian Immunodeficiency Virus Virulence1 , 2007, The Journal of Immunology.

[16]  Ronald S Veazey,et al.  Paucity of CD4 (cid:1) CCR5 (cid:1) T cells is a typical feature of natural SIV hosts , 2022 .

[17]  S. Staprans,et al.  Correlates of Preserved CD4+ T Cell Homeostasis during Natural, Nonpathogenic Simian Immunodeficiency Virus Infection of Sooty Mangabeys: Implications for AIDS Pathogenesis , 2007, The Journal of Immunology.

[18]  J. Brenchley,et al.  Microbial translocation is a cause of systemic immune activation in chronic HIV infection , 2006, Retrovirology.

[19]  F. Barré-Sinoussi,et al.  Simian Immunodeficiency Virus SIVagm.sab Infection of Caribbean African Green Monkeys: a New Model for the Study of SIV Pathogenesis in Natural Hosts , 2006, Journal of Virology.

[20]  V. Maino,et al.  Insufficient Production and Tissue Delivery of CD4+Memory T Cells in Rapidly Progressive Simian Immunodeficiency Virus Infection , 2004, The Journal of experimental medicine.

[21]  D. Price,et al.  CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract , 2004, The Journal of experimental medicine.

[22]  Mario Roederer,et al.  T-Cell Subsets That Harbor Human Immunodeficiency Virus (HIV) In Vivo: Implications for HIV Pathogenesis , 2004, Journal of Virology.

[23]  L. White,et al.  High levels of SIVmnd-1 replication in chronically infected Mandrillus sphinx. , 2003, Virology.

[24]  R. Koup,et al.  Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. , 2003, Immunity.

[25]  D. Ho,et al.  Normal T-Cell Turnover in Sooty Mangabeys Harboring Active Simian Immunodeficiency Virus Infection , 2000, Journal of Virology.

[26]  Yoshikawa,et al.  An African green monkey lacking peripheral CD4 lymphocytes that retains helper T cell activity and coexists with SIVagm , 1999, Clinical and experimental immunology.

[27]  Y. Murayama,et al.  CD4 and CD8 expressions in African green monkey helper T lymphocytes: implication for resistance to SIV infection. , 1997, International immunology.

[28]  Division on Earth.  Guide for the Care and Use of Laboratory Animals , 1996 .