Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing

[1]  D. Silberberg,et al.  Enhanced survival of rat neonatal cerebral cortical neurons at subatmospheric oxygen tensions in vitro , 1986, Brain Research.

[2]  T. Reinheckel,et al.  Proteolysis in Cultured Liver Epithelial Cells during Oxidative Stress , 1995, The Journal of Biological Chemistry.

[3]  J. M. Davies,et al.  Transient adaptation to oxidative stress in yeast. , 1995, Archives of biochemistry and biophysics.

[4]  K. Davies,et al.  Transient adaptation of oxidative stress in mammalian cells. , 1995, Archives of biochemistry and biophysics.

[5]  A. Jaiswal,et al.  Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[6]  T. Reinheckel,et al.  Degradation of Oxidized Proteins in K562 Human Hematopoietic Cells by Proteasome* , 1996, The Journal of Biological Chemistry.

[7]  T. Reinheckel,et al.  Degradation of oxidized proteins in mammalian cells , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[8]  K. Davies,et al.  Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[9]  K. Davies,et al.  Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II—aging of nondividing cells , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[10]  D. Housman,et al.  Functional genomics reveals a family of eukaryotic oxidation protection genes. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[11]  K. Davies,et al.  Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I— effects of proliferative senescence , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[12]  T. Grune,et al.  Proteolysis of oxidised proteins and cellular senescence , 2000, Experimental Gerontology.

[13]  E. Stadtman,et al.  Oxidative modification of proteins during aging , 2001, Experimental Gerontology.

[14]  K. Davies Degradation of oxidized proteins by the 20S proteasome. , 2001, Biochimie.

[15]  K. Davies,et al.  Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism , 2002, Nature Cell Biology.

[16]  S. Biswal,et al.  Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. , 2002, Cancer research.

[17]  K. Davies,et al.  Protein turnover by the proteasome in aging and disease. , 2002, Free radical biology & medicine.

[18]  K. Davies,et al.  Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress , 2002, FEBS letters.

[19]  T. Reinheckel,et al.  Ezrin turnover and cell shape changes catalyzed by proteasome in oxidatively stressed cells , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[20]  C. Wolf,et al.  Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. , 2002, The Biochemical journal.

[21]  K. Davies,et al.  The proteasomal system and HNE-modified proteins. , 2003, Molecular aspects of medicine.

[22]  A. I. Rojo,et al.  Regulation of Heme Oxygenase-1 Expression through the Phosphatidylinositol 3-Kinase/Akt Pathway and the Nrf2 Transcription Factor in Response to the Antioxidant Phytochemical Carnosol* , 2004, Journal of Biological Chemistry.

[23]  Anil K. Jaiswal,et al.  Bach1 Competes with Nrf2 Leading to Negative Regulation of the Antioxidant Response Element (ARE)-mediated NAD(P)H:Quinone Oxidoreductase 1 Gene Expression and Induction in Response to Antioxidants* , 2005, Journal of Biological Chemistry.

[24]  L. Herzenberg,et al.  Culturing at atmospheric oxygen levels impacts lymphocyte function. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[25]  Tilman Grune,et al.  Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains , 2006, Neurobiology of Aging.

[26]  Linda Partridge,et al.  Minireview Stress-response Hormesis and Aging: ''that Which Does Not Kill Us Makes Us Stronger'' Figure 1. Dose-response Curve of a Treatment with a Hormetic Effect Minireview Cell Metabolism , 2022 .

[27]  K. Davies,et al.  Mitochondrial Lon protease is a human stress protein. , 2009, Free radical biology & medicine.

[28]  N. Breusing,et al.  Inverse correlation of protein oxidation and proteasome activity in liver and lung , 2009, Mechanisms of Ageing and Development.

[29]  Tobias Jung,et al.  Age-related differences in oxidative protein-damage in young and senescent fibroblasts. , 2009, Archives of biochemistry and biophysics.

[30]  H. Forman,et al.  C‐Myc is a Nrf2‐interacting protein that negatively regulates phase II genes through their electrophile responsive elements , 2010, IUBMB life.

[31]  K. Davies,et al.  THE IMMUNOPROTEASOME, THE 20S PROTEASOME, AND THE PA28αβ PROTEASOME REGULATOR ARE OXIDATIVE STRESS‐ADAPTIVE PROTEOLYTIC COMPLEXES , 2010, The Biochemical journal.

[32]  H. Fox,et al.  Oxygen matters: tissue culture oxygen levels affect mitochondrial function and structure as well as responses to HIV viroproteins , 2011, Cell Death and Disease.

[33]  L. C. Pomatto,et al.  Impairment of lon-induced protection against the accumulation of oxidized proteins in senescent wi-38 fibroblasts. , 2011, The journals of gerontology. Series A, Biological sciences and medical sciences.

[34]  K. Davies,et al.  HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress. , 2011, Free radical biology & medicine.

[35]  K. Davies,et al.  Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration , 2011, PLoS genetics.

[36]  Christiane Ott,et al.  Advanced-glycation-end-product-induced formation of immunoproteasomes: involvement of RAGE and Jak2/STAT1. , 2012, The Biochemical journal.

[37]  T. Morgan,et al.  Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments. , 2012, Free radical biology & medicine.

[38]  K. Davies,et al.  Degradation of damaged proteins: the main function of the 20S proteasome. , 2012, Progress in molecular biology and translational science.

[39]  K. Davies,et al.  Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress* , 2012, The Journal of Biological Chemistry.

[40]  K. Davies,et al.  Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins. , 2012, Archives of biochemistry and biophysics.

[41]  V. Gorgoulis,et al.  Proteasome dysfunction in Drosophila signals to an Nrf2‐dependent regulatory circuit aiming to restore proteostasis and prevent premature aging , 2013, Aging cell.

[42]  K. Davies,et al.  A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster , 2013, Journal of Experimental Biology.

[43]  J. Tower,et al.  Oxidative stress adaptation with acute, chronic, and repeated stress. , 2013, Free radical biology & medicine.

[44]  L. C. Pomatto,et al.  Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging , 2013, Redox biology.

[45]  V. Gorgoulis,et al.  Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[46]  B. Friguet,et al.  Deletion of the mitochondrial Pim1/Lon protease in yeast results in accelerated aging and impairment of the proteasome. , 2013, Free radical biology & medicine.

[47]  J. Hayes,et al.  The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. , 2014, Trends in biochemical sciences.

[48]  M. S. Fernández-García,et al.  ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity. , 2014, Cell reports.

[49]  M. Bjørås,et al.  Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21. , 2014, Free radical biology & medicine.

[50]  A. Giaccia,et al.  Dual roles of NRF2 in tumor prevention and progression: possible implications in cancer treatment. , 2015, Free radical biology & medicine.

[51]  Richard A. Miller,et al.  Lifespan of mice and primates correlates with immunoproteasome expression. , 2015, The Journal of clinical investigation.

[52]  K. Davies,et al.  Oxidative stress response and Nrf2 signaling in aging. , 2015, Free radical biology & medicine.

[53]  E. Calabrese,et al.  What is hormesis and its relevance to healthy aging and longevity? , 2015, Biogerontology.

[54]  L. C. Pomatto,et al.  Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways. , 2016, Molecular aspects of medicine.

[55]  K. Davies,et al.  The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome , 2016, Free radical biology & medicine.

[56]  Joel N. Meyer,et al.  Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest , 2016, Redox biology.

[57]  M. Arno,et al.  Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels. , 2016, Free radical biology & medicine.

[58]  S. Giordano,et al.  The Dual Roles of NRF2 in Cancer. , 2016, Trends in molecular medicine.

[59]  K. Davies,et al.  Adaptive homeostasis. , 2016, Molecular aspects of medicine.

[60]  M. Arno,et al.  Quantifying the magnitude of the oxygen artefact inherent in culturing airway cells under atmospheric oxygen versus physiological levels , 2016, FEBS letters.

[61]  Sarah Wong,et al.  The Mitochondrial Lon Protease Is Required for Age-Specific and Sex-Specific Adaptation to Oxidative Stress , 2017, Current Biology.

[62]  K. Davies,et al.  Diminished stress resistance and defective adaptive homeostasis in age-related diseases. , 2017, Clinical science.

[63]  N. B. Sepuri,et al.  Mitochondrial LON protease-dependent degradation of cytochrome c oxidase subunits under hypoxia and myocardial ischemia. , 2017, Biochimica et biophysica acta. Bioenergetics.

[64]  L. C. Pomatto,et al.  The role of declining adaptive homeostasis in ageing , 2017, The Journal of physiology.

[65]  K. Davies,et al.  Aging and SKN-1-dependent Loss of 20S Proteasome Adaptation to Oxidative Stress in C. elegans , 2017, The journals of gerontology. Series A, Biological sciences and medical sciences.

[66]  Rong Li,et al.  Cytosolic proteostasis through importing of misfolded proteins into mitochondria , 2017, Nat..

[67]  L. C. Pomatto,et al.  Sexual dimorphism in oxidant-induced adaptive homeostasis in multiple wild-type D. melanogaster strains. , 2017, Archives of biochemistry and biophysics.

[68]  L. Florens,et al.  Cytosolic Proteostasis via Importing of Misfolded Proteins into Mitochondria , 2018 .

[69]  L. C. Pomatto,et al.  The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster , 2017, Aging.

[70]  L. C. Pomatto,et al.  Adaptive homeostasis and the free radical theory of ageing , 2018, Free radical biology & medicine.

[71]  K. Davies,et al.  Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells , 2017, Redox biology.

[72]  Jie Liu,et al.  Ontogeny and aging of Nrf2 pathway genes in livers of rats , 2018, Life sciences.

[73]  Aging effects on basal and lipopolysaccharide inducible expression of antioxidant and inflammatory genes in human blood monocytes , 2018 .

[74]  T. Morgan,et al.  Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic‐derived nanoparticles (‘vehicular smog’) , 2018, Free radical biology & medicine.

[75]  Ruth E. Thomas,et al.  Lon protease inactivation in Drosophila causes unfolded protein stress and inhibition of mitochondrial translation , 2018, Cell Death Discovery.

[76]  P. Biggin,et al.  Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase , 2018, Molecular Neurobiology.

[77]  J. P. Castro,et al.  Impaired proteostasis during skeletal muscle aging , 2019, Free radical biology & medicine.

[78]  L. C. Pomatto,et al.  To adapt or not to adapt: Consequences of declining Adaptive Homeostasis and Proteostasis with age , 2019, Mechanisms of Ageing and Development.

[79]  P. Oliver,et al.  Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum , 2018, Free radical biology & medicine.