Low dose exposure to HBCD, CB-153 or TCDD induces histopathological and hormonal effects and changes in brain protein and gene expression in juvenile female BALB/c mice.
暂无分享,去创建一个
A. Mantovani | F. Maranghi | A. Lundebye | R. Tassinari | C. Hogstrand | G. Moracci | I. Altieri | J. Rasinger | T. Carroll | Christer Hogstrand | Josef D. Rasinger | Thomas L. Carroll | Ilaria Altieri | Alberto Mantovani | Gabriele Moracci
[1] A. Lundebye,et al. Parallel in vivo and in vitro transcriptomics analysis reveals calcium and zinc signalling in the brain as sensitive targets of HBCD neurotoxicity , 2017, Archives of Toxicology.
[2] A. Mantovani,et al. The juvenile toxicity study as a tool for a science-based risk assessment in the children population group. , 2017, Reproductive toxicology.
[3] L. Madsen,et al. Lower levels of Persistent Organic Pollutants, metals and the marine omega 3‐fatty acid DHA in farmed compared to wild Atlantic salmon (Salmo salar) , 2017, Environmental research.
[4] A. Lundebye,et al. Methylmercury Induced Neurotoxicity and the Influence of Selenium in the Brains of Adult Zebrafish (Danio rerio) , 2017, International journal of molecular sciences.
[5] M. Mendez,et al. Metabolism disrupting chemicals and metabolic disorders. , 2017, Reproductive toxicology.
[6] C. Cornil. On the role of brain aromatase in females: why are estrogens produced locally when they are available systemically? , 2017, Journal of Comparative Physiology A.
[7] K. Kristiansen,et al. Marine fatty acids aggravate hepatotoxicity of α-HBCD in juvenile female BALB/c mice. , 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[8] A. Covaci,et al. Assessing in-vitro estrogenic effects of currently-used flame retardants. , 2016, Toxicology in vitro : an international journal published in association with BIBRA.
[9] M. Serrano,et al. G6PD protects from oxidative damage and improves healthspan in mice , 2016, Nature Communications.
[10] Jiping Chen,et al. New Insights into the Cytotoxic Mechanism of Hexabromocyclododecane from a Metabolomic Approach. , 2016, Environmental science & technology.
[11] B. Sures,et al. Review of hexabromocyclododecane (HBCD) with a focus on legislation and recent publications concerning toxicokinetics and -dynamics. , 2015, Environmental pollution.
[12] G. T. Marks,et al. Very low-dose (femtomolar) 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) disrupts steroidogenic enzyme mRNAs and steroid secretion by human luteinizing granulosa cells. , 2015, Reproductive toxicology.
[13] L. Madsen,et al. Contaminant levels in Norwegian farmed Atlantic salmon (Salmo salar) in the 13-year period from 1999 to 2011. , 2015, Environment international.
[14] A. Lundebye,et al. Cross-omics gene and protein expression profiling in juvenile female mice highlights disruption of calcium and zinc signalling in the brain following dietary exposure to CB-153, BDE-47, HBCD or TCDD. , 2014, Toxicology.
[15] Z. Ling,et al. Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress , 2014, The EMBO journal.
[16] T. de Wet,et al. Identifying important life stages for monitoring and assessing risks from exposures to environmental contaminants: results of a World Health Organization review , 2014, Regulatory toxicology and pharmacology : RTP.
[17] Matt Cave,et al. Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice. , 2013, The Journal of nutritional biochemistry.
[18] P. G. Wells,et al. Brain glucose-6-phosphate dehydrogenase protects against endogenous oxidative DNA damage and neurodegeneration in aged mice. , 2013, ACS chemical neuroscience.
[19] Chun Cheng,et al. 2,3,7,8-TCDD induces neurotoxicity and neuronal apoptosis in the rat brain cortex and PC12 cell line through the down-regulation of the Wnt/β-catenin signaling pathway. , 2013, Neurotoxicology.
[20] A. Mantovani,et al. Dietary exposure of juvenile female mice to polyhalogenated seafood contaminants (HBCD, BDE-47, PCB-153, TCDD): comparative assessment of effects in potential target tissues. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[21] Haiying Xiao,et al. Elevated T/E2 Ratio Is Associated with an Increased Risk of Cerebrovascular Disease in Elderly Men , 2013, PloS one.
[22] S. Gupte,et al. Glucose-6-Phosphate Dehydrogenase and NADPH Redox Regulates Cardiac Myocyte L-Type Calcium Channel Activity and Myocardial Contractile Function , 2012, PloS one.
[23] Alena Bartonova,et al. Environmental exposure to xenoestrogens and oestrogen related cancers: reproductive system, breast, lung, kidney, pancreas, and brain , 2012, Environmental Health.
[24] A. Mantovani,et al. Targeted toxicological testing to investigate the role of endocrine disrupters in puberty disorders. , 2012, Reproductive toxicology.
[25] Laura N. Vandenberg,et al. Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. , 2012, Endocrine reviews.
[26] M. van den Berg,et al. Some OH-PCBs are more potent inhibitors of aromatase activity and (anti-) glucocorticoids than non-dioxin like (NDL)-PCBs and MeSO₂-PCBs. , 2011, Toxicology letters.
[27] C. Tohyama,et al. Molecular targets that link dioxin exposure to toxicity phenotypes , 2011, The Journal of Steroid Biochemistry and Molecular Biology.
[28] A. Lundebye,et al. Cerebral gene expression and neurobehavioural development after perinatal exposure to an environmentally relevant polybrominated diphenylether (BDE47) , 2011, Cell Biology and Toxicology.
[29] A. Boobis,et al. Scientific Opinion on Hexabromocyclododecanes (HBCDDs) in Food , 2011 .
[30] A. Boobis,et al. Scientific Opinion on Polybrominated Diphenyl Ethers (PBDEs) in Food , 2011 .
[31] N. Koibuchi,et al. 1,2,5,6,9,10-αHexabromocyclododecane (HBCD) Impairs Thyroid Hormone-Induced Dendrite Arborization of Purkinje Cells and Suppresses Thyroid Hormone Receptor-Mediated Transcription , 2011, The Cerebellum.
[32] K. Poppe,et al. Thyroid function and human reproductive health. , 2010, Endocrine reviews.
[33] M. Mattson,et al. “Control” laboratory rodents are metabolically morbid: Why it matters , 2010, Proceedings of the National Academy of Sciences.
[34] Pamela J Lein,et al. Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity. , 2010, Pharmacology & therapeutics.
[35] E. Blalock,et al. Estradiol Reverses a Calcium-Related Biomarker of Brain Aging in Female Rats , 2009, The Journal of Neuroscience.
[36] A. Piersma,et al. Effects of the brominated flame retardant hexabromocyclododecane (HBCD) on dopamine-dependent behavior and brainstem auditory evoked potentials in a one-generation reproduction study in Wistar rats. , 2009, Toxicology Letters.
[37] A. Piersma,et al. Endocrine effects of hexabromocyclododecane (HBCD) in a one-generation reproduction study in Wistar rats. , 2009, Toxicology letters.
[38] Yanan Tian. Ah receptor and NF-kappaB interplay on the stage of epigenome. , 2009, Biochemical pharmacology.
[39] M. van den Berg,et al. Hexabromocyclododecane inhibits depolarization-induced increase in intracellular calcium levels and neurotransmitter release in PC12 cells. , 2009, Toxicological sciences : an official journal of the Society of Toxicology.
[40] So-Young Park,et al. 2,3,7,8-TCDD neurotoxicity in neuroblastoma cells is caused by increased oxidative stress, intracellular calcium levels, and tau phosphorylation. , 2009, Toxicology.
[41] J. Legler. New insights into the endocrine disrupting effects of brominated flame retardants. , 2008, Chemosphere.
[42] W. Boon,et al. Estrogen and adiposity—Utilizing models of aromatase deficiency to explore the relationship , 2007, The Journal of Steroid Biochemistry and Molecular Biology.
[43] N. Bénachour,et al. Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination. , 2007, Toxicology and applied pharmacology.
[44] D. Krause,et al. Androgenic/Estrogenic Balance in the Male Rat Cerebral Circulation: Metabolic Enzymes and Sex Steroid Receptors , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[45] Timo Hamers,et al. A 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in Wistar rats. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.
[46] G. Pearse. Histopathology of the Thymus , 2006, Toxicologic pathology.
[47] Timo Hamers,et al. In vitro profiling of the endocrine-disrupting potency of brominated flame retardants. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.
[48] Adrian Covaci,et al. Hexabromocyclododecanes (HBCDs) in the environment and humans: a review. , 2006, Environmental science & technology.
[49] T. Zacharewski,et al. Dioxin Induces an Estrogen-Like, Estrogen Receptor-Dependent Gene Expression Response in the Murine Uterus , 2006, Molecular Pharmacology.
[50] Evan R. Simpson,et al. Of mice and men: the evolving phenotype of aromatase deficiency , 2006, Trends in Endocrinology & Metabolism.
[51] S. Lambard,et al. Aromatase and estrogen receptors in male reproduction , 2006, Molecular and Cellular Endocrinology.
[52] J. Furr,et al. Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals. , 2006, International journal of andrology.
[53] P. Kodavanti. Neurotoxicity of Persistent Organic Pollutants: Possible Mode(S) of Action and Further Considerations , 2005, Dose-response : a publication of International Hormesis Society.
[54] M. Mann,et al. Exponentially Modified Protein Abundance Index (emPAI) for Estimation of Absolute Protein Amount in Proteomics by the Number of Sequenced Peptides per Protein*S , 2005, Molecular & Cellular Proteomics.
[55] Jae-Ho Yang,et al. Neurotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in cerebellar granule cells , 2005, Experimental & Molecular Medicine.
[56] W. Boon,et al. Estrogen deficiency leads to apoptosis in dopaminergic neurons in the medial preoptic area and arcuate nucleus of male mice , 2004, Molecular and Cellular Neuroscience.
[57] J. Haseman,et al. Follicular Epithelial Cell Hypertrophy Induced by Chronic Oral Administration of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Female Harlan Sprague—Dawley Rats , 2004, Toxicologic pathology.
[58] F. Fonnum,et al. The effect of brominated flame retardants on neurotransmitter uptake into rat brain synaptosomes and vesicles , 2003, Neurochemistry International.
[59] T. Spencer,et al. Estrogen and Antiestrogen Effects on Neonatal Ovine Uterine Development1 , 2003, Biology of reproduction.
[60] R. Aebersold,et al. A statistical model for identifying proteins by tandem mass spectrometry. , 2003, Analytical chemistry.
[61] Alexey I Nesvizhskii,et al. Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. , 2002, Analytical chemistry.
[62] C. V. van Noorden,et al. Glucose-6-phosphate dehydrogenase: the key to sex-related xenobiotic toxicity in hepatocytes of European flounder (Platichthys flesus L.)? , 2002, Aquatic toxicology.
[63] W. Mundy,et al. Inositol 1,4,5-triphosphate receptor-sensitive Ca(2+) release, store-operated Ca(2+) entry, and cAMP responsive element binding protein phosphorylation in developing cortical cells following exposure to polychlorinated biphenyls. , 2001, The Journal of pharmacology and experimental therapeutics.
[64] C. Hoe,et al. The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pancreatic Islet Pathology in Sprague—Dawley Rats , 2001, Toxicologic pathology.
[65] N. Skovgaard. Safety evaluation of certain food additives and contaminants , 2000 .
[66] N. Holbrook,et al. Oxidants, oxidative stress and the biology of ageing , 2000, Nature.
[67] Tak W. Mak,et al. Two Distinct Pathways Leading to Nuclear Apoptosis , 2000, The Journal of experimental medicine.
[68] D. Nebert,et al. Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis. , 2000, Biochemical pharmacology.
[69] K. Soper,et al. Diet, caloric restriction, and the rodent bioassay. , 1999, Toxicological sciences : an official journal of the Society of Toxicology.
[70] A. Shevchenko,et al. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. , 1996, Analytical chemistry.
[71] A. Shevchenko,et al. Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry , 1996, Nature.
[72] R. Kletzien,et al. Glucose‐6‐phosphate dehydrogenase: a “housekeeping” enzyme subject to tissue‐specific regulation by hormones, nutrients, and oxidant stress , 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[73] V. Vasiliou,et al. Role of the Ah Receptor and the Dioxin‐Inducible [Ah] Gene Battery in Toxicity, Cancer, and Signal Transduction a , 1993, Annals of the New York Academy of Sciences.
[74] T. Uede,et al. Flow cytometric and functional analysis of mononuclear cells infiltrating the liver in experimental autoimmune hepatitis , 1990, Clinical and experimental immunology.
[75] E. Smith,et al. Effects of estradiol and nicotinamide adenine dinucleotide phosphate on the rate of synthesis of uterine glucose 6-phosphate dehydrogenase. , 1974, The Journal of biological chemistry.
[76] D. Harman. Aging: a theory based on free radical and radiation chemistry. , 1956, Journal of gerontology.
[77] H. Campbell,et al. Diet , 1906, The Hospital.