Coexistence of diffuse plane normolipaemic xanthoma and amyloidosis in a patient with monoclonal gammopathy

Diffuse plane normolipaemic xanthomatosis (DPNX) is a well‐defined clinicopathological entity that characteristically presents with yellow–orange plaques in the periorbital areas, the neck, the upper trunk and the flexural folds. DPNX has been reported in association with lymphoproliferative disorders and, occasionally, with miscellaneous, probably coincidental disorders. A case of DPNX in a patient with an IgGλ monoclonal gammopathy and systemic amyloidosis is reported. Clinical and histopathological findings revealed typical features of DPNX and amyloidosis coexisting in the cutaneous lesions. To our knowledge this is the first reported case showing coexistence of xanthoma and amyloidosis in cutaneous lesions in a patient with a monoclonal gammopathy.

[1]  W. White,et al.  The spectrum of normolipemic plane xanthoma. , 1993, The American Journal of dermatopathology.

[2]  M. Price,et al.  Plane xanthomatosis with chronic lymphatic leukaemia , 1993, Clinical and experimental dermatology.

[3]  K. Adler,et al.  Cutaneous xanthomas associated with chronic myelomonocytic leukemia. , 1985, Archives of dermatology.

[4]  C. Conri,et al.  Xanthomes plans normolipémiques et myélome IgGĸ à activité anti-lipoprotéine , 1985 .

[5]  Kyle Ra,et al.  Amyloidosis (AL). Clinical and laboratory features in 229 cases. , 1983 .

[6]  R. Winkelmann.  Cutaneous syndromes of non-X histiocytosis. A review of the macrophage-histiocyte diseases of the skin. , 1981, Archives of dermatology.

[7]  S. Grundy,et al.  Normolipidemic planar xanthomatosis associated with benign monoclonal gammopathy. , 1981, Metabolism: clinical and experimental.

[8]  M. Black,et al.  Systemic amyloidosis and the skin: a review with special emphasis on clinical features and therapy , 1979, Clinical and experimental dermatology.

[9]  D. Colomb,et al.  [Xanthomatosis and monoclonal myelomatous gammapathy. About a case also associated with systemic amyloidosis. Review of 42 cases of literature (author's transl)]. , 1979, Annales de dermatologie et de venereologie.

[10]  R. Hunter,et al.  Normolipemic Plane Xanthoma and Histiocytic Lymphoma , 1976 .

[11]  L. Millard,et al.  Generalized Plane Xanthomata with Macroglobulinæmia , 1973, Proceedings of the Royal Society of Medicine.

[12]  M. Feiwel.  XANTHOMATOSIS IN CRYOGLOBULINAEMIA AND OTHER PARAPROTEINAEMIAS WITH REPORT OF A CASE * , 1968, The British journal of dermatology.

[13]  A. Walker,et al.  SKIN XANTHOMA FOLLOWING ERYTHRODERMA , 1968, The British journal of dermatology.

[14]  R. Winkelmann,et al.  Generalized plane xanthoma and systemic disease. , 1966, Archives of dermatology.

[15]  A. Neufeld,et al.  MYELOMATOSIS WITH XANTHOMATOSIS MULTIFORME. , 1964, Canadian Medical Association journal.

[16]  P. Borrie.  Diffuse normolipemic plane xanthoma. , 1963, Archives of dermatology.

[17]  R. Winkelmann,et al.  Diffuse normolipemic plane xanthoma. Generalized xanthelasma. , 1962, Archives of dermatology.

[18]  R. Grimalt,et al.  The various clinical patterns of xanthoma disseminatum. Considerations on seven cases and review of the literature. , 1995, Dermatology.

[19]  D. Gaveau,et al.  Xanthomatose diffuse normolipémique révélatrice d'un myélome à IgG kappa. , 1988 .

[20]  R. Kyle,et al.  Amyloidosis (AL). Clinical and laboratory features in 229 cases. , 1983, Mayo Clinic proceedings.

[21]  T. Rosen.  Dystrophic xanthomatosis in mycosis fungoides. , 1978, Archives of dermatology.