Modeling And Control Of Drug Effects Upon Physiological Systems: A Clinician's Viewpoint

Control of drug effects upon physiological systems requires dynamic models of drug effects on the cell lines of the hematopoetic system, for example. We have developed an effect model upon cell production or destruction which relates a Hill effect equation to the amount of drug in a slowly equilibrating peripheral compartment. Such models capture the delayed fall and recovery of cell lines seen with clinical data. Population models, and adaptive control of them, should permit coordinated use of multiple drugs to achieve multiple goals, keeping multiple other side effects within desired constraints. Supported by RR01629.