Modeling And Control Of Drug Effects Upon Physiological Systems: A Clinician's Viewpoint
暂无分享,去创建一个
Control of drug effects upon physiological systems requires dynamic models of drug effects on the cell lines of the hematopoetic system, for example. We have developed an effect model upon cell production or destruction which relates a Hill effect equation to the amount of drug in a slowly equilibrating peripheral compartment. Such models capture the delayed fall and recovery of cell lines seen with clinical data. Population models, and adaptive control of them, should permit coordinated use of multiple drugs to achieve multiple goals, keeping multiple other side effects within desired constraints. Supported by RR01629.
[1] A. Schumitzky. Nonparametric EM Algorithms for estimating prior distributions , 1991 .
[2] M. Egorin,et al. Human pharmacokinetics, excretion, and metabolism of the anthracycline antibiotic menogaril (7-OMEN, NSC 269148) and their correlation with clinical toxicities. , 1986, Cancer research.
[3] A Schumitzky,et al. A program package for simulation and parameter estimation in pharmacokinetic systems. , 1979, Computer programs in biomedicine.