The genetics of cardiovascular disease

[1]  J. Connell,et al.  Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols. , 2008, Journal of hypertension.

[2]  J. Webster,et al.  Glutathione S-transferase variants and hypertension , 2008, Journal of hypertension.

[3]  Nilesh J Samani,et al.  Common Variants in Genes Underlying Monogenic Hypertension and Hypotension and Blood Pressure in the General Population , 2008, Hypertension.

[4]  A. Dominiczak,et al.  Vascular stiffness is related to superoxide generation in the vessel wall , 2008, Journal of hypertension.

[5]  Martin Vingron,et al.  Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease , 2008, Nature Genetics.

[6]  Dudley J Pennell,et al.  Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass , 2008, Nature Genetics.

[7]  A. Singleton,et al.  Whole Genome Analyses Suggest Ischemic Stroke and Heart Disease Share an Association With Polymorphisms on Chromosome 9p21 , 2008, Stroke.

[8]  Hongyu Zhao,et al.  Rare independent mutations in renal salt handling genes contribute to blood pressure variation , 2008, Nature Genetics.

[9]  M. McCarthy,et al.  Genome-wide association studies for complex traits: consensus, uncertainty and challenges , 2008, Nature Reviews Genetics.

[10]  Edwin Cuppen,et al.  Progress and prospects in rat genetics: a community view , 2008, Nature Genetics.

[11]  Y. Teo,et al.  Common statistical issues in genome-wide association studies: a review on power, data quality control, genotype calling and population structure , 2008, Current opinion in lipidology.

[12]  L. Cupples Family study designs in the age of genome-wide association studies: experience from the Framingham Heart Study , 2008, Current opinion in lipidology.

[13]  S. Horvath,et al.  Variations in DNA elucidate molecular networks that cause disease , 2008, Nature.

[14]  H. Stefánsson,et al.  Genetics of gene expression and its effect on disease , 2008, Nature.

[15]  K. Oniki,et al.  Association between glutathione S-transferase A1, M1 and T1 polymorphisms and hypertension , 2008, Pharmacogenetics and genomics.

[16]  D. Strachan,et al.  LDL-cholesterol concentrations: a genome-wide association study , 2008, The Lancet.

[17]  Walter Kolch,et al.  Urinary Proteomic Biomarkers in Coronary Artery Disease*S , 2008, Molecular & Cellular Proteomics.

[18]  Dolores Corella,et al.  Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans , 2008, Nature Genetics.

[19]  Mario Falchi,et al.  Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia , 2022 .

[20]  M. Latronico,et al.  Emerging role of microRNAs in cardiovascular biology. , 2007, Circulation research.

[21]  M. Gaasenbeek,et al.  Candidate Genes That Determine Response to Salt in the Stroke-Prone Spontaneously Hypertensive Rat: Congenic Analysis , 2007, Hypertension.

[22]  Mark D. Robinson,et al.  A comparison of Affymetrix gene expression arrays , 2007, BMC Bioinformatics.

[23]  A. Dominiczak,et al.  Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future. , 2007, Journal of proteome research.

[24]  Matthew Chalmers,et al.  VisGenome: visualization of single and comparative genome representations , 2007, Bioinform..

[25]  Keith C. Norris,et al.  Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial , 2007, Journal of hypertension.

[26]  J. Sinsheimer,et al.  USF1 Contributes to High Serum Lipid Levels in Dutch FCHL Families and U.S. Whites With Coronary Artery Disease , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[27]  J. Murabito,et al.  Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study , 2007, BMC Medical Genetics.

[28]  Sudha Seshadri,et al.  Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes , 2007, BMC Medical Genetics.

[29]  Daniel Levy,et al.  Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness , 2007, BMC Medical Genetics.

[30]  G. Beunen,et al.  Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: heritabilities , 2007, Diabetologia.

[31]  C. Gieger,et al.  Genomewide association analysis of coronary artery disease. , 2007, The New England journal of medicine.

[32]  Markus Perola,et al.  Sweet taste preferences are partly genetically determined: identification of a trait locus on chromosome 16. , 2007, The American journal of clinical nutrition.

[33]  Robert A. Hegele,et al.  Copy Number Variation in the Human Genome and Its Implications for Cardiovascular Disease , 2007, Circulation.

[34]  D. Levy,et al.  Heritability, Linkage, and Genetic Associations of Exercise Treadmill Test Responses , 2007, Circulation.

[35]  A. Gylfason,et al.  A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction , 2007, Science.

[36]  A. Bowcock Genomics: Guilt by association , 2007, Nature.

[37]  Simon C. Potter,et al.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls , 2007, Nature.

[38]  Marcia M. Nizzari,et al.  Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels , 2007, Science.

[39]  Sonja W. Scholz,et al.  A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release , 2007, The Lancet Neurology.

[40]  G. Uhl,et al.  Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs , 2007, BMC Genetics.

[41]  R. Redon,et al.  Relative Impact of Nucleotide and Copy Number Variation on Gene Expression Phenotypes , 2007, Science.

[42]  B. Stegmayr,et al.  Genome-Wide Linkage Scan of Common Stroke in Families From Northern Sweden , 2007, Stroke.

[43]  A. Isaacs,et al.  The involvement of upstream stimulatory factor 1 in Dutch patients with familial combined hyperlipidemias⃞ Published, JLR Papers in Press, October 25, 2006. , 2007, Journal of Lipid Research.

[44]  K. Gunderson,et al.  Whole genome genotyping technologies on the BeadArray™ platform , 2007 .

[45]  D. Conrad,et al.  Global variation in copy number in the human genome , 2006, Nature.

[46]  Francis S. Collins,et al.  Genes, environment and the value of prospective cohort studies , 2006, Nature Reviews Genetics.

[47]  F. Schick,et al.  Upstream transcription factor 1 gene polymorphisms are associated with high antilipolytic insulin sensitivity and show gene–gene interactions , 2006, Journal of Molecular Medicine.

[48]  Ryan E. Mills,et al.  An initial map of insertion and deletion (INDEL) variation in the human genome. , 2006, Genome research.

[49]  Philippe Froguel,et al.  Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples From Populations With Replicated Evidence of Linkage to Chromosome 1q , 2006, Diabetes.

[50]  I. Kronzon,et al.  Aortic Atherosclerotic Disease and Stroke , 2006, Circulation.

[51]  J. Díez,et al.  The C242T CYBA polymorphism of NADPH oxidase is associated with essential hypertension , 2006, Journal of hypertension.

[52]  A. Lumsden,et al.  Chlamydia pneumoniae and vascular disease: an update. , 2006, Journal of vascular surgery.

[53]  Alan D. Lopez,et al.  Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data , 2006, The Lancet.

[54]  Chiara Sabatti,et al.  Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies , 2006, Nature Genetics.

[55]  N. Dzimiri,et al.  T null and M null genotypes of the glutathione S-transferase gene are risk factor for CAD independent of smoking , 2006, BMC Medical Genetics.

[56]  F. Hu,et al.  A Common Genetic Variant Is Associated with Adult and Childhood Obesity , 2006, Science.

[57]  L. Peltonen,et al.  Risk Alleles of USF1 Gene Predict Cardiovascular Disease of Women in Two Prospective Studies , 2006, PLoS genetics.

[58]  N. Samani,et al.  Chromosome 2p Shows Significant Linkage to Antihypertensive Response in the British Genetics of Hypertension Study , 2006, Hypertension.

[59]  P. Pagano,et al.  Targeting reactive oxygen species in hypertension , 2006, Current opinion in nephrology and hypertension.

[60]  Martin Farrall,et al.  Genetic susceptibility to coronary artery disease: from promise to progress , 2006, Nature Reviews Genetics.

[61]  Michael Mueller,et al.  eQTL Explorer: integrated mining of combined genetic linkage and expression experiments , 2006, Bioinform..

[62]  V. Salomaa,et al.  Coronary heart disease: from a disease of middle-aged men in the late 1970s to a disease of elderly women in the 2000s. , 2006, European heart journal.

[63]  M. Abney,et al.  The sex-specific genetic architecture of quantitative traits in humans , 2006, Nature Genetics.

[64]  H. Stefánsson,et al.  Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes , 2006, Nature Genetics.

[65]  Mike Tyers,et al.  BioGRID: a general repository for interaction datasets , 2005, Nucleic Acids Res..

[66]  K. S. Deshpande,et al.  Human protein reference database—2006 update , 2005, Nucleic Acids Res..

[67]  Thangavel Alphonse Thanaraj,et al.  ASD: a bioinformatics resource on alternative splicing , 2005, Nucleic Acids Res..

[68]  Mark Woodward,et al.  Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies , 2005, BMJ : British Medical Journal.

[69]  M. Tobin,et al.  Association of WNK1 Gene Polymorphisms and Haplotypes With Ambulatory Blood Pressure in the General Population , 2005, Circulation.

[70]  P. Burton,et al.  A genomewide linkage study of 1,933 families affected by premature coronary artery disease: The British Heart Foundation (BHF) Family Heart Study. , 2005, American journal of human genetics.

[71]  J. Staessen,et al.  Adducin and hypertension. , 2005, Pharmacogenomics.

[72]  Lyle J Palmer,et al.  Genetic Epidemiology 4 Shaking the tree : mapping complex disease genes with linkage disequilibrium , 2022 .

[73]  L. Peltonen,et al.  USF1 and dyslipidemias: converging evidence for a functional intronic variant. , 2005, Human molecular genetics.

[74]  Päivi Pajukanta,et al.  Familial Combined Hyperlipidemia in Mexicans: Association With Upstream Transcription Factor 1 and Linkage on Chromosome 16q24.1 , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[75]  P. Arner,et al.  Upstream transcription factor-1 gene polymorphism is associated with increased adipocyte lipolysis. , 2005, The Journal of clinical endocrinology and metabolism.

[76]  M. Ng,et al.  The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in the Chinese population , 2005, Diabetologia.

[77]  N. Samani,et al.  Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study. , 2005, Human molecular genetics.

[78]  G. Zalba,et al.  NADPH Oxidase—Dependent Superoxide Production Is Associated With Carotid Intima-Media Thickness in Subjects Free of Clinical Atherosclerotic Disease , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[79]  R. Karas,et al.  Molecular and Cellular Basis of Cardiovascular Gender Differences , 2005, Science.

[80]  J. Rinn,et al.  Sexual dimorphism in mammalian gene expression. , 2005, Trends in genetics : TIG.

[81]  K. Gunderson,et al.  A genome-wide scalable SNP genotyping assay using microarray technology , 2005, Nature Genetics.

[82]  A. Edwards,et al.  Complement Factor H Polymorphism and Age-Related Macular Degeneration , 2005, Science.

[83]  J. Ott,et al.  Complement Factor H Polymorphism in Age-Related Macular Degeneration , 2005, Science.

[84]  A. Dominiczak,et al.  Reduction of Gstm1 Expression in the Stroke-Prone Spontaneously Hypertension Rat Contributes to Increased Oxidative Stress , 2005, Hypertension.

[85]  Jonathan C. Cohen,et al.  Lack of MEF2A mutations in coronary artery disease. , 2005, The Journal of clinical investigation.

[86]  D. Allison,et al.  Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level , 2005, Journal of Molecular Medicine.

[87]  K. Taylor,et al.  A Genome-Wide Scan for Carotid Artery Intima-Media Thickness: The Mexican-American Coronary Artery Disease Family Study , 2005, Stroke.

[88]  A. Dominiczak,et al.  Corcoran Lecture. Cardiovascular genomics and oxidative stress. , 2005, Hypertension.

[89]  L. Pennacchio,et al.  Insulin-Mediated Down-Regulation of Apolipoprotein A5 Gene Expression through the Phosphatidylinositol 3-Kinase Pathway: Role of Upstream Stimulatory Factor , 2005, Molecular and Cellular Biology.

[90]  A. Yashin,et al.  The heritability of CHD mortality in danish twins after controlling for smoking and BMI. , 2005, Twin research and human genetics : the official journal of the International Society for Twin Studies.

[91]  M. Daly,et al.  Genome-wide association studies for common diseases and complex traits , 2005, Nature Reviews Genetics.

[92]  V. Salomaa,et al.  Association of European population levels of thrombotic and inflammatory factors with risk of coronary heart disease: the MONICA Optional Haemostasis Study. , 2005, European heart journal.

[93]  T. Klockgether,et al.  Heritability of Carotid Artery Atherosclerotic Lesions: An Ultrasound Study in 154 Families , 2005, Stroke.

[94]  Tatiana A. Tatusova,et al.  Entrez Gene: gene-centered information at NCBI , 2004, Nucleic Acids Res..

[95]  S. P. Fodor,et al.  Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays , 2004, Nature Methods.

[96]  M. Sillanpää,et al.  Replication in genetic studies of complex traits , 2004, Annals of human genetics.

[97]  M. Ng,et al.  Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. , 2004, Diabetes.

[98]  S. Yusuf,et al.  Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study , 2004, The Lancet.

[99]  Nathan D. Wong,et al.  Impact of the Metabolic Syndrome on Mortality From Coronary Heart Disease, Cardiovascular Disease, and All Causes in United States Adults , 2004, Circulation.

[100]  Silke Schmidt,et al.  A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study. , 2004, American journal of human genetics.

[101]  D. Tregouet,et al.  Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II. , 2004, Human molecular genetics.

[102]  N. Martin,et al.  The genetics of alcohol intake and of alcohol dependence. , 2004, Alcoholism, clinical and experimental research.

[103]  Kenny Q. Ye,et al.  Large-Scale Copy Number Polymorphism in the Human Genome , 2004, Science.

[104]  Meir J Stampfer,et al.  Meta-Analysis: Apolipoprotein E Genotypes and Risk for Coronary Heart Disease , 2004, Annals of Internal Medicine.

[105]  Y. Kokubo,et al.  Genetic analysis of 22 candidate genes for hypertension in the Japanese population , 2004, Journal of hypertension.

[106]  M. Ng,et al.  Genome-wide scan for type 2 diabetes loci in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. , 2004, Diabetes.

[107]  Ralph B D'Agostino,et al.  Risk of complications of pregnancy in women with type 1 diabetes: nationwide prospective study in the Netherlands , 2004, BMJ : British Medical Journal.

[108]  P. Donnelly,et al.  The effects of human population structure on large genetic association studies , 2004, Nature Genetics.

[109]  Lisa M. D'Souza,et al.  Genome sequence of the Brown Norway rat yields insights into mammalian evolution , 2004, Nature.

[110]  D. Tregouet,et al.  In-Depth Haplotype Analysis of ABCA1 Gene Polymorphisms in Relation to Plasma ApoA1 Levels and Myocardial Infarction , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[111]  P. Rothwell,et al.  Heritability of Ischemic Stroke in Relation to Age, Vascular Risk Factors, and Subtypes of Incident Stroke in Population-Based Studies , 2004, Stroke.

[112]  A. Dominiczak,et al.  Strategies to reduce oxidative stress in cardiovascular disease. , 2004, Clinical science.

[113]  J. Gulcher,et al.  The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke , 2004, Nature Genetics.

[114]  L. Peltonen,et al.  Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1) , 2004, Nature Genetics.

[115]  R. Langer,et al.  Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002 : Section 4: lessons from hormone replacement trials. , 2004, Circulation.

[116]  N. Roodi,et al.  Association of Homozygous Wild-Type Glutathione S-Transferase M1 Genotype with Increased Breast Cancer Risk , 2004, Cancer Research.

[117]  M. McCarthy,et al.  Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to Type 2 diabetes , 2004, Diabetologia.

[118]  Eric J Topol,et al.  Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis. , 2004, American journal of human genetics.

[119]  Anthony Gamst,et al.  Association of the Metabolic Syndrome With History of Myocardial Infarction and Stroke in the Third National Health and Nutrition Examination Survey , 2004, Circulation.

[120]  H. Jacob,et al.  Application of chromosomal substitution techniques in gene‐function discovery , 2004, The Journal of physiology.

[121]  Gregory D. Schuler,et al.  Database resources of the National Center for Biotechnology Information: update , 2004, Nucleic acids research.

[122]  E. Rimm,et al.  A QTL genome scan of the metabolic syndrome and its component traits , 2003, BMC Genetics.

[123]  R. Becker,et al.  Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies. , 2003, American heart journal.

[124]  E. Topol,et al.  Mutation of MEF2A in an Inherited Disorder with Features of Coronary Artery Disease , 2003, Science.

[125]  Sarah A Tishkoff,et al.  Patterns of human genetic diversity: implications for human evolutionary history and disease. , 2003, Annual review of genomics and human genetics.

[126]  M. Fresno,et al.  Basic Helix Loop Helix Transcription Factor involved in the regulation of Upstream Stimulatory Factor Activity , 2003 .

[127]  E. Boerwinkle,et al.  Effects of endothelial nitric oxide synthase, alpha-adducin, and other candidate gene polymorphisms on blood pressure response to hydrochlorothiazide. , 2003, American journal of hypertension.

[128]  Mark Gurney,et al.  The gene encoding phosphodiesterase 4D confers risk of ischemic stroke , 2003, Nature Genetics.

[129]  Hanno Steen,et al.  Development of human protein reference database as an initial platform for approaching systems biology in humans. , 2003, Genome research.

[130]  Patricia B. Munroe,et al.  Genome-wide mapping of human loci for essential hypertension ☆ , 2003 .

[131]  W. Lalouschek,et al.  Association of parental history of stroke with clinical parameters in patients with ischemic stroke or transient ischemic attack. , 2003, Stroke.

[132]  J. Pankow,et al.  Coronary Artery Disease Risk in Familial Combined Hyperlipidemia and Familial Hypertriglyceridemia: A Case-Control Comparison From the National Heart, Lung, and Blood Institute Family Heart Study , 2003, Circulation.

[133]  A. Fukamizu,et al.  Cloning and characterization of a novel splicing isoform of USF1. , 2003, International Journal of Molecular Medicine.

[134]  John D. Storey,et al.  Statistical significance for genomewide studies , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[135]  Doron Lancet,et al.  GeneLoc: exon-based integration of human genome maps , 2003, ISMB.

[136]  B. Nordestgaard,et al.  Angiotensinogen Gene Polymorphism, Plasma Angiotensinogen, and Risk of Hypertension and Ischemic Heart Disease: A Meta-Analysis , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[137]  H. Krumholz,et al.  Overestimation of genetic risks owing to small sample sizes in cardiovascular studies , 2003, Clinical genetics.

[138]  S. Harrap Where are all the blood-pressure genes? , 2003, The Lancet.

[139]  D. Ramsdale,et al.  Acute coronary syndrome: unstable angina and non-ST segment elevation myocardial infarction. , 2003 .

[140]  R. Stein,et al.  Upstream stimulatory factor (USF) and neurogenic differentiation/beta-cell E box transactivator 2 (NeuroD/BETA2) contribute to islet-specific glucose-6-phosphatase catalytic-subunit-related protein (IGRP) gene expression. , 2003, The Biochemical journal.

[141]  M L Simoons,et al.  Logistics and quality control for DNA sampling in large multicenter studies , 2003, Journal of thrombosis and haemostasis : JTH.

[142]  P. Talmud,et al.  Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges. , 2003, Biochimica et biophysica acta.

[143]  C. Giménez,et al.  Identification of a non-canonical E-box motif as a regulatory element in the proximal promoter region of the apolipoprotein E gene. , 2003, The Biochemical journal.

[144]  R. Norio The Finnish disease heritage III: the individual diseases , 2003, Human Genetics.

[145]  S. Yap Classical homocystinuria: Vascular risk and its prevention , 2003, Journal of Inherited Metabolic Disease.

[146]  A. Dominiczak,et al.  Microarray Analysis of Rat Chromosome 2 Congenic Strains , 2003, Hypertension.

[147]  Daniel Pinkel,et al.  Whole genome analysis of genetic alterations in small DNA samples using hyperbranched strand displacement amplification and array-CGH. , 2003, Genome research.

[148]  T. Sellers,et al.  Review of proteomics with applications to genetic epidemiology , 2003, Genetic epidemiology.

[149]  M. Wagner,et al.  Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24. , 2003, Diabetes.

[150]  E. Lander,et al.  Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease , 2003, Nature Genetics.

[151]  Jukka T Salonen,et al.  The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. , 2002, JAMA.

[152]  Petra Verhoef,et al.  MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis. , 2002, JAMA.

[153]  P. Heutink,et al.  Gene finding in genetically isolated populations. , 2002, Human molecular genetics.

[154]  A. Yashin,et al.  Heritability of death from coronary heart disease: a 36‐year follow‐up of 20 966 Swedish twins , 2002, Journal of internal medicine.

[155]  L. Le Marchand,et al.  Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk. , 2002, Carcinogenesis.

[156]  Tom H. Pringle,et al.  The human genome browser at UCSC. , 2002, Genome research.

[157]  A. Tonkin,et al.  Genome-Wide Linkage Analysis of the Acute Coronary Syndrome Suggests a Locus on Chromosome 2 , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[158]  R. Myers,et al.  Candidate-gene approaches for studying complex genetic traits: practical considerations , 2002, Nature Reviews Genetics.

[159]  J. Chambaz,et al.  Two Initiator-like Elements Are Required for the Combined Activation of the Human Apolipoprotein C-III Promoter by Upstream Stimulatory Factor and Hepatic Nuclear Factor-4* , 2002, The Journal of Biological Chemistry.

[160]  Mathew W. Wright,et al.  Guidelines for human gene nomenclature. , 2002, Genomics.

[161]  Eric S. Lander,et al.  On the sequencing of the human genome , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[162]  Patrick Royston,et al.  Autosomal Genome-Wide Scan for Coronary Artery Calcification Loci in Sibships at High Risk for Hypertension , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[163]  P. Rouet,et al.  Transcriptional regulation of adipocyte hormone-sensitive lipase by glucose. , 2002, Diabetes.

[164]  H. Brewer,et al.  The E-box motif in the proximal ABCA1 promoter mediates transcriptional repression of the ABCA1 gene. , 2002, Journal of lipid research.

[165]  Trevor L Hawkins,et al.  Whole genome amplification--applications and advances. , 2002, Current opinion in biotechnology.

[166]  I. Klein,et al.  Promoter I of the ovine acetyl-CoA carboxylase-alpha gene: an E-box motif at -114 in the proximal promoter binds upstream stimulatory factor (USF)-1 and USF-2 and acts as an insulin-response sequence in differentiating adipocytes. , 2001, The Biochemical journal.

[167]  Frank Dudbridge,et al.  Haplotype tagging for the identification of common disease genes , 2001, Nature Genetics.

[168]  Sagiv Shifman,et al.  The value of isolated populations , 2001, Nature Genetics.

[169]  T. D. de Bruin,et al.  Excess coronary heart disease in Familial Combined Hyperlipidemia, in relation to genetic factors and central obesity. , 2001, Atherosclerosis.

[170]  R. Hanson,et al.  Family and genetic studies of indices of insulin sensitivity and insulin secretion in Pima Indians † ‡ , 2001, Diabetes/metabolism research and reviews.

[171]  J. Dutil,et al.  Further chromosomal mapping of a blood pressure QTL in Dahl rats on chromosome 2 using congenic strains. , 2001, Physiological genomics.

[172]  Mi-Hye Lee,et al.  Genetic basis of sitosterolemia , 2001, Current opinion in lipidology.

[173]  L. Groop,et al.  Cardiovascular morbidity and mortality associated with the metabolic syndrome. , 2001, Diabetes care.

[174]  Timothy B. Stockwell,et al.  The Sequence of the Human Genome , 2001, Science.

[175]  J. V. Moran,et al.  Initial sequencing and analysis of the human genome. , 2001, Nature.

[176]  A. Dominiczak,et al.  Superoxide Excess in Hypertension and Aging: A Common Cause of Endothelial Dysfunction , 2001, Hypertension.

[177]  Kenneth Lange,et al.  Use of population isolates for mapping complex traits , 2000, Nature Reviews Genetics.

[178]  M. Daly,et al.  Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. , 2000, American journal of human genetics.

[179]  C. Dina,et al.  Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. , 2000, American journal of human genetics.

[180]  K. Channon,et al.  Functional Effect of the C242T Polymorphism in the NAD(P)H Oxidase p22phox Gene on Vascular Superoxide Production in Atherosclerosis , 2000, Circulation.

[181]  L. Jorde,et al.  Linkage disequilibrium and the search for complex disease genes. , 2000, Genome research.

[182]  J. Jurka Repbase update: a database and an electronic journal of repetitive elements. , 2000, Trends in genetics : TIG.

[183]  V. Salomaa,et al.  The feasibility of routine mortality and morbidity register data linkage to study the occurrence of acute coronary heart disease events in Finland , 2000, European Journal of Epidemiology.

[184]  X. Jeunemaître,et al.  The future of genetic association studies in hypertension: improving the signal‐to‐noise ratio , 2000, Journal of hypertension.

[185]  N. Risch Searching for genetic determinants in the new millennium , 2000, Nature.

[186]  E. Winzeler,et al.  Genomics, gene expression and DNA arrays , 2000, Nature.

[187]  C. Wild,et al.  Glutathione S‐transferase M1 null genotype is associated with a decreased risk of myocardial infarction , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[188]  A. Dobson,et al.  Estimation of contribution of changes in classic risk factors to trends in coronary-event rates across the WHO MONICA Project populations , 2000, The Lancet.

[189]  Mario Pirastu,et al.  Population choice in mapping genes for complex diseases , 1999, Nature Genetics.

[190]  J. Piette,et al.  Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1 , 1999, Nature Genetics.

[191]  A. Dominiczak,et al.  Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium. , 1999, Hypertension.

[192]  J F Cornhill,et al.  Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study. , 1999, JAMA.

[193]  D. Kardassis,et al.  Cooperative Binding of Upstream Stimulatory Factor and Hepatic Nuclear Factor 4 Drives the Transcription of the Human Apolipoprotein A-II Gene* , 1999, The Journal of Biological Chemistry.

[194]  M. Ehm,et al.  An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians. , 1998, American journal of human genetics.

[195]  P. Kwok,et al.  Reading bits of genetic information: methods for single-nucleotide polymorphism analysis. , 1998, Genome research.

[196]  H. Tunstall-Pedoe Myth and paradox of coronary risk and the menopause , 1998, The Lancet.

[197]  T. Lehtimäki,et al.  Linkage of familial combined hyperlipidaemia to chromosome 1q21–q23 , 1998, Nature Genetics.

[198]  E. Naughten,et al.  Newborn screening for homocystinuria: Irish and world experience , 1998, European Journal of Pediatrics.

[199]  D. Wang,et al.  Upstream Stimulatory Factor Binding to the E-box at −65 Is Required for Insulin Regulation of the Fatty Acid Synthase Promoter* , 1997, The Journal of Biological Chemistry.

[200]  A. Dominiczak,et al.  Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus , 1997, Nature Genetics.

[201]  J. Tuomilehto,et al.  Stroke incidence and mortality correlated to stroke risk factors in the WHO MONICA Project. An ecological study of 18 populations. , 1997, Stroke.

[202]  T. Mune,et al.  11β-Hydroxysteroid Dehydrogenase and the Syndrome of Apparent Mineralocorticoid Excess , 1997 .

[203]  Janet B. Dunbar,et al.  Incidence, natural history and cardiovascular events in symptomatic and asymptomatic peripheral arterial disease in the general population. , 1996, International journal of epidemiology.

[204]  M. Bihoreau,et al.  Quantitative trait loci in genetically hypertensive rats. Possible sex specificity. , 1996, Hypertension.

[205]  N Risch,et al.  The Future of Genetic Studies of Complex Human Diseases , 1996, Science.

[206]  E. Vartiainen,et al.  Parental history of premature coronary heart disease: an independent risk factor of myocardial infarction. , 1996, Journal of clinical epidemiology.

[207]  A. Dominiczak,et al.  Vascular smooth muscle polyploidy and cardiac hypertrophy in genetic hypertension. , 1996, Hypertension.

[208]  E. Vartiainen,et al.  Diabetes mellitus as a risk factor for death from stroke. Prospective study of the middle-aged Finnish population. , 1996, Stroke.

[209]  B. Viollet,et al.  Immunochemical Characterization and Transacting Properties of Upstream Stimulatory Factor Isoforms (*) , 1996, The Journal of Biological Chemistry.

[210]  A. Dominiczak,et al.  Role of superoxide in the depressed nitric oxide production by the endothelium of genetically hypertensive rats. , 1995, Hypertension.

[211]  E. Lander,et al.  Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results , 1995, Nature Genetics.

[212]  S. Devries,et al.  Analysis of changes in DNA sequence copy number by comparative genomic hybridization in archival paraffin-embedded tumor samples. , 1994, The American journal of pathology.

[213]  J. Witte,et al.  Genetic dissection of complex traits. , 1994, Nature genetics.

[214]  H. Tunstall-Pedoe,et al.  Myocardial Infarction and Coronary Deaths in the World Health Organization MONICA Project: Registration Procedures, Event Rates, and Case‐Fatality Rates in 38 Populations From 21 Countries in Four Continents , 1994, Circulation.

[215]  K. Docherty,et al.  The helix-loop-helix transcription factor USF (upstream stimulating factor) binds to a regulatory sequence of the human insulin gene enhancer. , 1993, The Biochemical journal.

[216]  P. Wolf,et al.  Familial Aggregation of Stroke: The Framingham Study , 1993, Stroke.

[217]  G. Mcclearn,et al.  Genetic and environmental influences on serum lipid levels in twins. , 1993, The New England journal of medicine.

[218]  R. Gaynor,et al.  Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23. , 1993, Genomics.

[219]  R. Hubert,et al.  Whole genome amplification from a single cell: implications for genetic analysis. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[220]  N. Carter,et al.  Degenerate oligonucleotide-primed PCR: general amplification of target DNA by a single degenerate primer. , 1992, Genomics.

[221]  J. Lalouel,et al.  A chimaeric llβ-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension , 1992, Nature.

[222]  R. Roeder,et al.  Cooperative interaction of an initiator-binding transcription initiation factor and the helix–loop–helix activator USF , 1991, Nature.

[223]  R. Roeder,et al.  The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer. , 1990, Genes & development.

[224]  J. Weber,et al.  Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. , 1989, American journal of human genetics.

[225]  R. Roeder,et al.  Multiple forms of the human gene-specific transcription factor USF. I. Complete purification and identification of USF from HeLa cell nuclei. , 1988, The Journal of biological chemistry.

[226]  M. Sawadogo Multiple forms of the human gene-specific transcription factor USF. II. DNA binding properties and transcriptional activity of the purified HeLa USF. , 1988, The Journal of biological chemistry.

[227]  R. Krauss,et al.  Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[228]  R. L. Prentice,et al.  A case-cohort design for epidemiologic cohort studies and disease prevention trials , 1986 .

[229]  C. Mathew,et al.  Blot hybridisation analysis of genomic DNA. , 1984, Journal of medical genetics.

[230]  M. Wigler,et al.  Human-tumor-derived cell lines contain common and different transforming genes , 1981, Cell.

[231]  D. Botstein,et al.  Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[232]  A. Motulsky,et al.  Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction. , 1973, The Journal of clinical investigation.

[233]  A. Motulsky,et al.  Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. , 1973, The Journal of clinical investigation.

[234]  H. G. Khorana Synthesis in the study of nucleic acids. The Fourth Jubilee Lecture. , 1968, The Biochemical journal.

[235]  J. H. Matthaei,et al.  Characteristics and composition of RNA coding units. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[236]  Marshall W. Nirenberg,et al.  The dependence of cell-free protein synthesis in E. coli upon naturally occurring or synthetic polyribonucleotides , 1961, Proceedings of the National Academy of Sciences.

[237]  F. Crick,et al.  Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid , 1953, Nature.

[238]  Peter Donnelly,et al.  Replicating genotype – phenotype associations What constitutes replication of a genotype – phenotype association , and how best can it be achieved ? , 2007 .

[239]  J. Witteman,et al.  ACE polymorphisms. , 2006, Circulation research.

[240]  J. Erdmann,et al.  Genetics and heritability of coronary artery disease and myocardial infarction , 2006, Clinical Research in Cardiology.

[241]  T. Ogihara,et al.  Single Nucleotide Polymorphisms in the Interleukin-6 Gene Associated with Blood Pressure and Atherosclerosis in a Japanese General Population , 2005, Hypertension Research.

[242]  A. Dominiczak,et al.  The visual language of synteny. , 2004, Omics : a journal of integrative biology.

[243]  K. Xiang,et al.  Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese: significant linkage to chromosome 6q21-q23 and chromosome 1q21-q24. , 2004, Diabetes.

[244]  Galina Deyneko,et al.  Whole genome amplification of DNA from laser capture-microdissected tissue for high-throughput single nucleotide polymorphism and short tandem repeat genotyping. , 2004, The American journal of pathology.

[245]  Sue Povey,et al.  Genew: the Human Gene Nomenclature Database, 2004 updates , 2004, Nucleic Acids Res..

[246]  Thangavel Alphonse Thanaraj,et al.  ASD: the Alternative Splicing Database , 2004, Nucleic Acids Res..

[247]  Alexander E. Kel,et al.  TRANSFAC®: transcriptional regulation, from patterns to profiles , 2003, Nucleic Acids Res..

[248]  D. Haussler,et al.  The Ucsc Genome Browser Database , 2022 .

[249]  L. Wagner,et al.  21. UniGene: A Unified View of the Transcriptome , 2003 .

[250]  M. Garrett,et al.  Multiple blood pressure QTL on rat Chromosome 2 defined by congenic Dahl rats , 2001, Mammalian Genome.

[251]  Elizabeth M. Smigielski,et al.  dbSNP: the NCBI database of genetic variation , 2001, Nucleic Acids Res..

[252]  A. Dominiczak,et al.  Applicability of a "speed" congenic strategy to dissect blood pressure quantitative trait loci on rat chromosome 2. , 2000, Hypertension.

[253]  J P Rapp,et al.  Genetic analysis of inherited hypertension in the rat. , 2000, Physiological reviews.

[254]  S Rozen,et al.  Primer3 on the WWW for general users and for biologist programmers. , 2000, Methods in molecular biology.

[255]  P. Poulsen,et al.  Heritability of Type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance – a population-based twin study , 1999, Diabetologia.

[256]  T Varilo,et al.  Molecular genetics of the Finnish disease heritage. , 1999, Human molecular genetics.

[257]  G. Reaven Role of insulin resistance in human disease (syndrome X): an expanded definition. , 1993, Annual review of medicine.

[258]  C. H. Conrad,et al.  Impaired myocardial function in spontaneously hypertensive rats with heart failure. , 1991, The American journal of physiology.

[259]  S. Grundy,et al.  Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[260]  L. J. Wei,et al.  The Robust Inference for the Cox Proportional Hazards Model , 1989 .

[261]  D. Rao,et al.  Twin study of genetic and environmental effects on lipid levels , 1988, Genetic epidemiology.

[262]  K. Mullis,et al.  Specific enzymatic amplification of DNA in vitro: the polymerase chain reaction. , 1986, Cold Spring Harbor symposia on quantitative biology.

[263]  M. Brown,et al.  The LDL receptor locus and the genetics of familial hypercholesterolemia. , 1979, Annual review of genetics.