Epigallocatechin-3-gallate is a potent phytochemical inhibitor of intimal hyperplasia in the wire-injured carotid artery.

[1]  Yu Han,et al.  (-)-Epigallocatechin gallate suppresses proliferation of vascular smooth muscle cells induced by high glucose by inhibition of PKC and ERK1/2 signalings. , 2011, Journal of agricultural and food chemistry.

[2]  O. Blaschuk,et al.  Inhibition of N-cadherin retards smooth muscle cell migration and intimal thickening via induction of apoptosis , 2010, Journal of vascular surgery.

[3]  Jong-Chul Park,et al.  Underlying mechanism for suppression of vascular smooth muscle cells by green tea polyphenol EGCG released from biodegradable polymers for stent application. , 2010, Journal of biomedical materials research. Part A.

[4]  Junfa Li,et al.  VCAM-1 siRNA reduces neointimal formation after surgical mechanical injury of the rat carotid artery. , 2009, Journal of vascular surgery.

[5]  K. Nakayama,et al.  S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo , 2009, Journal of vascular surgery.

[6]  T. V. Berkel,et al.  Local lentiviral short hairpin RNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice. , 2009, Journal of vascular surgery.

[7]  T. Itoh,et al.  Sarpogrelate hydrochloride reduced intimal hyperplasia in experimental rabbit vein graft. , 2009, Journal of vascular surgery.

[8]  A. Heim,et al.  Inhibition of smooth muscle cell migration and neointima formation in vein grafts by overexpression of matrix metalloproteinase-3. , 2009, Journal of vascular surgery.

[9]  P. Hornick,et al.  Therapeutics of vein graft intimal hyperplasia: 100 years on. , 2007, The Annals of thoracic surgery.

[10]  G. Tipoe,et al.  Green tea polyphenols as an anti-oxidant and anti-inflammatory agent for cardiovascular protection. , 2007, Cardiovascular & hematological disorders drug targets.

[11]  J. Park,et al.  Epigallocatechin-3-gallate inhibits the PDGF-induced VEGF expression in human vascular smooth muscle cells via blocking PDGF receptor and Erk-1/2. , 2006, International journal of oncology.

[12]  K. Park,et al.  Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway , 2006, Experimental & Molecular Medicine.

[13]  Yoshihiko Maehara,et al.  Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits. , 2006, Journal of vascular surgery.

[14]  J. Schrader,et al.  Lipoplex gene transfer of inducible nitric oxide synthase inhibits the reactive intimal hyperplasia after expanded polytetrafluoroethylene bypass grafting. , 2006, Journal of vascular surgery.

[15]  K. Kotoh,et al.  Epigallocatechin-3-gallate, a green-tea polyphenol, suppresses Rho signaling in TWNT-4 human hepatic stellate cells. , 2005, The Journal of laboratory and clinical medicine.

[16]  Cheorl-Ho Kim,et al.  Epigallocatechin-3-gallate causes the p21/WAF1-mediated G1-phase arrest of cell cycle and inhibits matrix metalloproteinase-9 expression in TNF-α-induced vascular smooth muscle cells , 2005 .

[17]  M. Cho,et al.  Local delivery of green tea catechins inhibits neointimal formation in the rat carotid artery injury model , 2004, Heart and Vessels.

[18]  X. Cheng,et al.  Green tea catechins inhibit neointimal hyperplasia in a rat carotid arterial injury model by TIMP-2 overexpression. , 2004, Cardiovascular research.

[19]  H. Ahn,et al.  Inhibitory Effect of Epigallocatechin 3-O-Gallate on Vascular Smooth Muscle Cell Hypertrophy Induced by Angiotensin II , 2004, Journal of cardiovascular pharmacology.

[20]  B. Sumpio,et al.  Antisense basic fibroblast growth factor alters the time course of mitogen-activated protein kinase in arterialized vein graft remodeling. , 2003, Journal of vascular surgery.

[21]  W. Quist,et al.  Evaluation of anastomotic hyperplasia progression using the cyclin specific antibody MIB-1. , 1996, American journal of surgery.

[22]  M. Reidy,et al.  Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. , 1983, Laboratory investigation; a journal of technical methods and pathology.

[23]  D. Tulis.  Rat carotid artery balloon injury model. , 2007, Methods in molecular medicine.

[24]  F. H. Sims.  A Comparison of Structural Features of the Walls of Coronary Arteries from 10 Different Species , 1989, Pathology.

[25]  K. Schrör,et al.  The FASEB Journal express article 10.1096/fj.03-0007fje. Published online November 20, 2003. Mechanisms , 2022 .