Monte Carlo simulations of receptor dynamics: Insights into cell signaling

[1]  J. Linderman,et al.  Monte Carlo simulations of membrane signal transduction events: Effect of receptor blockers on G-protein activation , 1995, Annals of Biomedical Engineering.

[2]  Jennifer J Linderman,et al.  Integrin dimerization and ligand organization: key components in integrin clustering for cell adhesion. , 2005, Tissue engineering.

[3]  Peter J Woolf,et al.  An algebra of dimerization and its implications for G-protein coupled receptor signaling. , 2004, Journal of theoretical biology.

[4]  Arup K Chakraborty,et al.  The Immunological Synapse Balances T Cell Receptor Signaling and Degradation , 2003, Science.

[5]  H. Wiley,et al.  An integrated model of epidermal growth factor receptor trafficking and signal transduction. , 2003, Biophysical journal.

[6]  Krzysztof Palczewski,et al.  Organization of the G Protein-coupled Receptors Rhodopsin and Opsin in Native Membranes* , 2003, Journal of Biological Chemistry.

[7]  S. V. Aksenov,et al.  A spatially extended stochastic model of the bacterial chemotaxis signalling pathway. , 2003, Journal of molecular biology.

[8]  Renhao Li,et al.  Activation of Integrin αIIbß3 by Modulation of Transmembrane Helix Associations , 2003, Science.

[9]  Peter J Woolf,et al.  Self organization of membrane proteins via dimerization. , 2003, Biophysical chemistry.

[10]  W. S. Hlavacek,et al.  Investigation of Early Events in FcεRI-Mediated Signaling Using a Detailed Mathematical Model1 , 2003, The Journal of Immunology.

[11]  Shuichi Takayama,et al.  Micro- and nanotechnologies for studying cellular function. , 2003, Current topics in medicinal chemistry.

[12]  J. Linderman,et al.  Untangling ligand induced activation and desensitization of G-protein-coupled receptors. , 2003, Biophysical journal.

[13]  James R Faeder,et al.  Investigation of early events in Fc epsilon RI-mediated signaling using a detailed mathematical model. , 2003, Journal of immunology.

[14]  Terrence J Sejnowski,et al.  A Monte Carlo model reveals independent signaling at central glutamatergic synapses. , 2002, Biophysical journal.

[15]  Emmanuel Laplantine,et al.  The integrin β1 subunit cytoplasmic tail forms oligomers: a potential role in β1 integrin clustering , 2002 .

[16]  S. Myou,et al.  Regulation of adhesion of AML14.3D10 cells by surface clustering of β2‐integrin caused by ERK‐independent activation of cPLA2 , 2002, Immunology.

[17]  Jon A. Rowley,et al.  Biomaterials to Spatially Regulate Cell Fate , 2002 .

[18]  Douglas A Lauffenburger,et al.  Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus. , 2002, Journal of cell science.

[19]  Jason M Haugh,et al.  A unified model for signal transduction reactions in cellular membranes. , 2002, Biophysical journal.

[20]  Philip Seeman,et al.  Atypical Antipsychotics: Mechanism of Action , 2002, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[21]  Michael J. Saxton,et al.  Chemically limited reactions on a percolation cluster , 2002 .

[22]  Linda G Griffith,et al.  Simulations of cell-surface integrin binding to nanoscale-clustered adhesion ligands. , 2002, Biophysical journal.

[23]  L. Devi,et al.  G-protein-coupled receptor dimerization: modulation of receptor function. , 2001, Pharmacology & therapeutics.

[24]  Renhao Li,et al.  Oligomerization of the integrin αIIbβ3: Roles of the transmembrane and cytoplasmic domains , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[25]  Lakshmi A. Devi,et al.  G protein coupled receptor dimerization: implications in modulating receptor function , 2001, Journal of Molecular Medicine.

[26]  S. Kapur,et al.  Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis. , 2001, The American journal of psychiatry.

[27]  T. Kenakin,et al.  Uncovering biases in high throughput screens of G-protein coupled receptors. , 2001, Journal of theoretical biology.

[28]  P. Conn,et al.  Gonadotropin-releasing Hormone Receptor Microaggregation RATE MONITORED BY FLUORESCENCE RESONANCE ENERGY TRANSFER* , 2001 .

[29]  J. Linderman,et al.  From the Static to the Dynamic: Three Models of Signal Transduction in G Protein-Coupled Receptors , 2000 .

[30]  B N Kholodenko,et al.  Diffusion control of protein phosphorylation in signal transduction pathways. , 2000, The Biochemical journal.

[31]  D. Broday,et al.  Diffusion of clusters of transmembrane proteins as a model of focal adhesion remodeling , 2000, Bulletin of mathematical biology.

[32]  L. Sander Diffusion-limited aggregation: A kinetic critical phenomenon? , 2000 .

[33]  U. Kumar,et al.  Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. , 2000, Science.

[34]  S. Angers,et al.  Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[35]  J. Linderman Kinetic Modeling Approaches to Understanding Ligand Efficacy , 2000 .

[36]  J. Linderman,et al.  Modeling activation and desensitization of G-protein coupled receptors provides insight into ligand efficacy. , 1999, Journal of theoretical biology.

[37]  C. Martínez-A,et al.  The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[38]  U. Bhalla,et al.  Emergent properties of networks of biological signaling pathways. , 1999, Science.

[39]  A. G. Roseberry,et al.  Desensitization of G-protein-coupled receptors in the cardiovascular system. , 1999, Annual review of physiology.

[40]  D A Lauffenburger,et al.  Analysis of receptor internalization as a mechanism for modulating signal transduction. , 1998, Journal of theoretical biology.

[41]  R. Mailman,et al.  Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency. , 1998, The Journal of pharmacology and experimental therapeutics.

[42]  M. Caron,et al.  Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[43]  M. Bouvier,et al.  Structural and functional aspects of G protein-coupled receptor oligomerization. , 1998, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[44]  J. Benovic,et al.  The role of receptor kinases and arrestins in G protein-coupled receptor regulation. , 1998, Annual review of pharmacology and toxicology.

[45]  D. Bray,et al.  Signaling complexes: biophysical constraints on intracellular communication. , 1998, Annual review of biophysics and biomolecular structure.

[46]  J. Linderman,et al.  Calculation of diffusion-limited kinetics for the reactions in collision coupling and receptor cross-linking. , 1997, Biophysical journal.

[47]  Ronald L. Wasserstein,et al.  Monte Carlo: Concepts, Algorithms, and Applications , 1997 .

[48]  Xiao-jun Xu,et al.  The development of morphine tolerance and dependence in rats with chronic pain , 1997, Brain Research.

[49]  Jennifer J. Linderman,et al.  Receptor Up-regulation, Internalization, and Interconverting Receptor States , 1996, The Journal of Biological Chemistry.

[50]  Kenneth M. Yamada,et al.  Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function , 1995, Science.

[51]  M. Rothkegel,et al.  The molecular architecture of focal adhesions. , 1995, Annual review of cell and developmental biology.

[52]  J. Linderman,et al.  A Monte Carlo study of the dynamics of G-protein activation. , 1994, Biophysical journal.

[53]  D. Lauffenburger,et al.  Receptors: Models for Binding, Trafficking, and Signaling , 1993 .

[54]  R. Neubig,et al.  Compartmentation of receptors and guanine nucleotide-binding proteins in NG108-15 cells: lack of cross-talk in agonist binding among the alpha 2-adrenergic, muscarinic, and opiate receptors. , 1993, Molecular pharmacology.

[55]  Robert B. Gennis,et al.  Biomembranes: Molecular Structure and Function , 1988 .

[56]  M. Caron,et al.  beta-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation. , 1988, The Journal of biological chemistry.

[57]  Terrence P. Kenakin,et al.  A Pharmacologic Analysis of Drug-Receptor Interaction , 1987 .

[58]  L. Sander,et al.  Diffusion-limited aggregation, a kinetic critical phenomenon , 1981 .

[59]  R P STEPHENSON,et al.  A MODIFICATION OF RECEPTOR THEORY , 1997, British journal of pharmacology and chemotherapy.

[60]  H. Kowarzyk Structure and Function. , 1910, Nature.