Pan Vascular Medicine

ion of the y-hydrogen of 10-13 glutamate residues, near the NH2-terminal end of the nascent preproprotein. This leaves a carbanion that is attacked by free C02 forming y-carboxyglutamic acid. The negative charge elicited from this string of Gla residues contributes to the binding to ca>+ and the generation of the appropriate conformation to bind to anionic phospholipid membrane [46, 47]. One important target for anticoagulant therapy is the process required for the regeneration of reduced hydro-

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