LKB1; linking cell structure and tumor suppression
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[1] V. McKusick,et al. Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits; a syndrome of diagnostic significance. , 2010, The New England journal of medicine.
[2] A J Krush,et al. Increased risk of cancer in the Peutz-Jeghers syndrome. , 1987, The New England journal of medicine.
[3] D. Morton,et al. Identification of genes required for cytoplasmic localization in early C. elegans embryos , 1988, Cell.
[4] A. Spigelman,et al. Cancer and the Peutz-Jeghers syndrome. , 1989, Gut.
[5] E. Brand. Peutz-Jeghers syndrome with ovarian sex cord tumor with annular tubules and cervical adenoma malignum. , 1992, Gynecologic oncology.
[6] P. Fisher,et al. Cell cycle arrest. , 1995, Science.
[7] S. Bulun,et al. Feminizing Sertoli Cell Tumors in Boys with Peutz‐Jeghers Syndrome , 1995, The American journal of surgical pathology.
[8] Darryl Shibata,et al. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis , 1997, Nature Genetics.
[9] G. Drewes,et al. MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption , 1997, Cell.
[10] R. Houlston,et al. Peutz-Jeghers syndrome. , 1997, Journal of medical genetics.
[11] M. Polymeropoulos,et al. Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome. , 1998, Cancer research.
[12] I. Tomlinson,et al. Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes. , 1998, The American journal of pathology.
[13] S. Seal,et al. Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer. , 1998, Cancer research.
[14] L. Aaltonen,et al. Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors. , 1998, Cancer research.
[15] M. Stratton,et al. A serine/threonine kinase gene defective in Peutz–Jeghers syndrome , 1998, Nature.
[16] P. Boor,et al. Peutz-Jeghers syndrome: 78-year follow-up of the original family , 1999, The Lancet.
[17] T. Mäkelä,et al. Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[18] W. Bodmer,et al. Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas. , 1999, The Journal of investigative dermatology.
[19] P. Guldberg,et al. Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma , 1999, Oncogene.
[20] R. Hruban,et al. Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. , 1999, The American journal of pathology.
[21] I Tomlinson,et al. Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz‐Jeghers' syndrome provides evidence for a hamartoma–(adenoma)–carcinoma sequence , 1999, The Journal of pathology.
[22] L. Aaltonen,et al. LKB1 somatic mutations in sporadic tumors. , 1999, The American journal of pathology.
[23] S. Goodman,et al. Very high risk of cancer in familial Peutz-Jeghers syndrome. , 2000, Gastroenterology.
[24] T. Iwama,et al. Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome. , 2000, Cancer research.
[25] D. Morton,et al. The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. , 2000, Development.
[27] D. Goudie,et al. An investigation of the Peutz-Jeghers gene (LKB1) in sporadic breast and colon cancers , 2000, Journal of clinical pathology.
[28] J. Herman,et al. Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome , 2000, Oncogene.
[29] G. Thomas,et al. Peutz-Jeghers families unlinked toSTK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma , 2001, Journal of medical genetics.
[30] J. Keller,et al. Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome , 2001, Journal of clinical pathology.
[31] X. Ding,et al. Prevention of pancreatic cancer induction in hamsters by metformin. , 2001, Gastroenterology.
[32] K. Alitalo,et al. Vascular Abnormalities and Deregulation of VEGF in Lkb1-Deficient Mice , 2001, Science.
[33] J. Cameron,et al. STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. , 2001, The American journal of pathology.
[34] G. Sapkota,et al. Phosphorylation of the Protein Kinase Mutated in Peutz-Jeghers Cancer Syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent Protein Kinase, but Not Its Farnesylation at Cys433, Is Essential for LKB1 to Suppress Cell Growth* , 2001, The Journal of Biological Chemistry.
[35] G. Sapkota,et al. Identification and characterization of four novel phosphorylation sites (Ser 31 , Ser 325 , Thr 336 and Thr 366 ) on LKB1/STK11, the protein kinase mutated in Peutz–Jeghers cancer syndrome , 2022 .
[36] A. Macpherson,et al. In siblings with similar genetic susceptibility for inflammatory bowel disease, smokers tend to develop Crohn's disease and non-smokers develop ulcerative colitis , 2002, Gut.
[37] M. Dunlop. Guidance on gastrointestinal surveillance for hereditary non-polyposis colorectal cancer, familial adenomatous polypolis, juvenile polyposis, and Peutz-Jeghers syndrome , 2002, Gut.
[38] C. Smythe,et al. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. , 2002, The Biochemical journal.
[39] Ronald A. DePinho,et al. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation , 2002, Nature.
[40] L. Aaltonen,et al. Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[41] K. Jishage,et al. Role of Lkb1, the causative gene of Peutz–Jegher's syndrome, in embryogenesis and polyposis , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[42] David Sidransky,et al. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. , 2002, Cancer research.
[43] T. Mäkelä,et al. Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1). , 2002, Human molecular genetics.
[44] R. DePinho,et al. LKB1 (XEEK1) regulates Wnt signalling in vertebrate development , 2003, Nature Cell Biology.
[45] Y. Peterson,et al. Interaction of Activator of G-protein Signaling 3 (AGS3) with LKB1, a Serine/Threonine Kinase Involved in Cell Polarity and Cell Cycle Progression , 2003, Journal of Biological Chemistry.
[46] A. Dopazo,et al. Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3'-phosphate kinase/PTEN pathway. , 2003, Cancer research.
[47] H C Clevers,et al. Activation of the tumour suppressor kinase LKB1 by the STE20‐like pseudokinase STRAD , 2003, The EMBO journal.
[48] S. Gruber,et al. Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[49] E. Montgomery,et al. Loss of Stk11/Lkb1 Expression in Pancreatic and Biliary Neoplasms , 2003, Modern Pathology.
[50] Jérôme Boudeau,et al. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade , 2003, Journal of biology.
[51] 三好 弘之. Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice , 2003 .
[52] 中右 雅之. Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice , 2003 .
[53] A. Ashworth,et al. Regulation of the Wnt signalling component PAR1A by the Peutz–Jeghers syndrome kinase LKB1 , 2003, Oncogene.
[54] E. Furth,et al. Clinicopathologic and Molecular Features of Pancreatic Adenocarcinoma Associated with Peutz-Jeghers Syndrome , 2003, Cancer biology & therapy.
[55] Daniel St Johnston,et al. A role for Drosophila LKB1 in anterior–posterior axis formation and epithelial polarity , 2003, Nature.
[56] D. M. Glover,et al. Genome-wide survey of protein kinases required for cell cycle progression , 2004, Nature.
[57] Derrick J. Rossi,et al. Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2. , 2004, Gastroenterology.
[58] R. DePinho,et al. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. , 2004, Genes & development.
[59] Jérôme Boudeau,et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 , 2004, The EMBO journal.
[60] David Carling,et al. The AMP-activated protein kinase cascade--a unifying system for energy control. , 2004, Trends in biochemical sciences.
[61] A. Prescott,et al. Analysis of the LKB1-STRAD-MO25 complex , 2004, Journal of Cell Science.
[62] J. Yates,et al. The CREB Coactivator TORC2 Functions as a Calcium- and cAMP-Sensitive Coincidence Detector , 2004, Cell.
[63] Hans Clevers,et al. LKB1 tumor suppressor protein: PARtaker in cell polarity. , 2004, Trends in cell biology.
[64] P. Brennwald,et al. Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton , 2004, The Journal of cell biology.
[65] Hans C Clevers,et al. Complete Polarization of Single Intestinal Epithelial Cells upon Activation of LKB1 by STRAD , 2004, Cell.
[66] R. DePinho,et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. , 2004, Cancer cell.
[67] M. Washington,et al. TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia , 2004, Science.
[68] Lewis C Cantley,et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[69] S. Gruber,et al. Relative frequency and morphology of cancers in STK11 mutation carriers. , 2004, Gastroenterology.
[70] T. Ratliff. TGF-Beta Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia , 2004 .
[71] Hans Clevers,et al. Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. , 2005, Human molecular genetics.
[72] C. Amos,et al. Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. , 2005, Cancer research.
[73] S. Antonarakis,et al. Peutz–Jeghers LKB1 mutants fail to activate GSK-3β, preventing it from inhibiting Wnt signaling , 2005, Molecular Genetics and Genomics.
[74] A. Reymond,et al. LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes. , 2005, Human molecular genetics.
[75] Kei Sakamoto,et al. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction , 2005, The EMBO journal.
[76] Russell G. Jones,et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. , 2005, Molecular cell.
[77] Dario R Alessi,et al. Metformin and reduced risk of cancer in diabetic patients , 2005, BMJ : British Medical Journal.
[78] R. DePinho,et al. The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin , 2005, Science.
[79] P. Propping,et al. High proportion of large genomic STK11 deletions in Peutz‐Jeghers syndrome , 2005, Human mutation.
[80] M. Caplan,et al. AMP-activated protein kinase regulates the assembly of epithelial tight junctions , 2006, Proceedings of the National Academy of Sciences.
[81] Kei Sakamoto,et al. LKB1-dependent signaling pathways. , 2006, Annual review of biochemistry.
[82] S. Gruber,et al. Frequency and Spectrum of Cancers in the Peutz-Jeghers Syndrome , 2006, Clinical Cancer Research.
[83] R. Roy,et al. Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling , 2006, Development.
[84] C. Kahn,et al. Skeletal Muscle-Selective Knockout of LKB1 Increases Insulin Sensitivity, Improves Glucose Homeostasis, and Decreases TRB3 , 2006, Molecular and Cellular Biology.
[85] Nahum Sonenberg,et al. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. , 2006, Cancer research.
[86] D. Cohen,et al. PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells. , 2006, Molecular biology of the cell.
[87] Xin-Yuan Fu,et al. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer , 2006, Nature.
[88] Richard Lugg,et al. Mutation analysis of 24 known cancer genes in the NCI-60 cell line set , 2006, Molecular Cancer Therapeutics.
[89] H. Clevers,et al. Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis , 2005, Gut.
[90] R. Shaw,et al. Glucose metabolism and cancer. , 2006, Current opinion in cell biology.
[91] T. Bohane,et al. Peutz-Jeghers syndrome and management recommendations. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
[92] Miao Zhang,et al. Activation of Protein Kinase Cζ by Peroxynitrite Regulates LKB1-dependent AMP-activated Protein Kinase in Cultured Endothelial Cells* , 2006, Journal of Biological Chemistry.
[93] L. Aaltonen,et al. LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome , 2005, Journal of Medical Genetics.
[94] S. Bonaccorsi,et al. The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division , 2007, Development.
[95] J. Sanes,et al. LKB1 and SAD Kinases Define a Pathway Required for the Polarization of Cortical Neurons , 2007, Cell.
[96] H. Clevers,et al. Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer , 2007, Oncogene.
[97] M. Billaud,et al. Dialogue Between LKB1 and AMPK: A Hot Topic at the Cellular Pole , 2007, Science's STKE.
[98] Y. Fukada,et al. LKB1 Regulates Neuronal Migration and Neuronal Differentiation in the Developing Neocortex through Centrosomal Positioning , 2007, The Journal of Neuroscience.
[99] T. Mäkelä,et al. Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization , 2007, Proceedings of the National Academy of Sciences.
[100] Gordon B. Mills,et al. The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis , 2007, Nature Cell Biology.
[101] T. Vallenius,et al. The LKB1 tumor suppressor kinase in human disease. , 2007, Biochimica et biophysica acta.
[102] Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1[+/-]p53[-/-] compound mutant mice , 2007 .
[103] Yuan Tian,et al. Par1b promotes hepatic-type lumen polarity in Madin Darby canine kidney cells via myosin II- and E-cadherin-dependent signaling. , 2007, Molecular biology of the cell.
[104] Miao Zhang,et al. Reactive Nitrogen Species Induced by Hyperglycemia Suppresses Akt Signaling and Triggers Apoptosis by Upregulating Phosphatase PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) in an LKB1-Dependent Manner , 2007, Circulation.
[105] L. Cantley,et al. Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase , 2007, Proceedings of the National Academy of Sciences.
[106] D. Neil Hayes,et al. LKB1 modulates lung cancer differentiation and metastasis , 2007, Nature.
[107] G. Shulman,et al. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo , 2007, Proceedings of the National Academy of Sciences.
[108] Jun Hee Lee,et al. Energy-dependent regulation of cell structure by AMP-activated protein kinase , 2007, Nature.
[109] D. Hardie,et al. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy , 2007, Nature Reviews Molecular Cell Biology.
[110] M. Poo,et al. LKB1/STRAD Promotes Axon Initiation During Neuronal Polarization , 2007, Cell.
[111] H. Piwnica-Worms,et al. The Par-1/MARK Family of Protein Kinases: From Polarity to Metabolism , 2007, Cell cycle.
[112] B. Kemp,et al. Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells. , 2008, Cancer research.
[113] Y. Miyagi,et al. LKB1 protein expression in neuroendocrine tumors of the lung , 2008, Pathology international.
[114] M. Zou,et al. Protein Kinase Cζ-dependent LKB1 Serine 428 Phosphorylation Increases LKB1 Nucleus Export and Apoptosis in Endothelial Cells* , 2008, Journal of Biological Chemistry.
[115] M. Hatakeyama,et al. Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA , 2008, Oncogene.
[116] E. Sahin,et al. LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis. , 2008, Cancer research.
[117] A. Ashworth,et al. Lkb1 deficiency causes prostate neoplasia in the mouse. , 2008, Cancer research.
[118] Gerald C. Chu,et al. Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms , 2008, Molecular and Cellular Biology.
[119] Xu Huang,et al. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. , 2008, The Biochemical journal.
[120] M. Meyerson,et al. Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients , 2008, British Journal of Cancer.
[121] B. Turk,et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. , 2008, Molecular cell.
[122] A. Marcus,et al. The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity. , 2008, Cancer research.
[123] Kwok-Kin Wong,et al. Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas. , 2008, Cancer research.
[124] C. Amos,et al. Suppression of Peutz-Jeghers Polyposis by Targeting Mammalian Target of Rapamycin Signaling , 2008, Clinical Cancer Research.
[125] R. DePinho,et al. LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis , 2008, Nature Genetics.
[126] B. Viollet,et al. AMP-activated Protein Kinase Phosphorylates and Desensitizes Smooth Muscle Myosin Light Chain Kinase*♦ , 2008, Journal of Biological Chemistry.
[127] S Etienne-Manneville,et al. Polarity proteins in migration and invasion , 2008, Oncogene.
[128] T. Williams,et al. LKB1 and AMPK in cell polarity and division. , 2008, Trends in cell biology.