论文信息 - Renal tumors and hereditary pheochromocytoma-paraganglioma syndrome type 4. - 字舞流文

Renal tumors and hereditary pheochromocytoma-paraganglioma syndrome type 4.

This letter indicates that immunohistochemical analysis to detect succinic dehydrogenase subunit B (SDHB) protein can screen renal tumors for underlying SDHB germline mutations at a fraction of the time and cost of formal genetic testing.

A. Gill | N. Pachter | I. Winship | K. Tucker | B. Robinson | R. Clifton-Bligh | D. Benn | A. Clarkson

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[2] A. Chou,et al. Immunohistochemistry for SDHB Divides Gastrointestinal Stromal Tumors (GISTs) into 2 Distinct Types , 2010, The American journal of surgical pathology.

[3] Fiona Douglas,et al. Tumor risks and genotype–phenotype–proteotype analysis in 358 patients with germline mutations in SDHB and SDHD , 2010, Human mutation.

[4] E. van Marck,et al. An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis. , 2009, The Lancet. Oncology.