Minimally invasive oesophagectomy versus open surgery: is there an advantage?

BackgroundOesophageal resection is the main method of curative treatment for cancer of the oesophagus. Despite advances in surgical technology and postoperative care, the survival rate and prognosis of people undergoing oesophagectomy is still poor. The use of minimally invasive techniques in oesophageal surgery offers hope of reduced recovery time due to a reduction in surgical trauma. Although the first reports of thoracoscopy- and laparoscopy-assisted oesophagectomy emerged some 20 years ago, there is still no consensus that the outcomes are clearly superior to outcomes following conventional open surgery. Increasingly, some surgeons promote the use of minimally invasive techniques for oesophagectomy but questions remain over its safety and efficacy compared with open surgery.MethodsWe conducted a systematic review of the literature to compare minimally invasive techniques for oesophagectomy to open surgery. The outcomes of interest for efficacy and safety included mortality, operative complications, recurrence, and quality of life.ResultsThere were 28 included comparative studies. No randomised controlled studies (RCTs) were available and therefore the data need to be interpreted with caution.ConclusionRecommendations for future research are discussed. We argue that it is difficult to conduct an RCT for this procedure due to ethical considerations and suggest ways that future nonrandomised studies could be improved.

[1]  V. Bresadola,et al.  Laparoscopic Versus Open Gastroplasty in Esophagectomy for Esophageal Cancer: A Comparative Study , 2006, Surgical laparoscopy, endoscopy & percutaneous techniques.

[2]  D. Torgerson,et al.  Designing randomised trials in health, education and the social sciences : an introduction , 2008 .

[3]  D. Jayne,et al.  Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC Trial Group. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[4]  D. Gotley,et al.  Comparison of the Outcomes Between Open and Minimally Invasive Esophagectomy , 2007, Annals of surgery.

[5]  Suzanne S Gisbertz,et al.  Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial , 2012, The Lancet.

[6]  E. Levine,et al.  Initial Institutional Experience with Thoracoscopic Assisted Esophagectomy , 2010, The American surgeon.

[7]  M. Migliore,et al.  A surgeon's case volume of oesophagectomy for cancer strongly influences the operative mortality rate. , 2007, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[8]  P. Mcculloch,et al.  Systematic review of minimally invasive resection for gastro‐oesophageal cancer , 2007, The British journal of surgery.

[9]  D. Moher,et al.  The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. , 2001, Journal of the American Podiatric Medical Association.

[10]  D. Moher,et al.  CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials , 2010, BMJ : British Medical Journal.

[11]  J Cubitt,et al.  Review of open and minimal access approaches to oesophagectomy for cancer , 2010, The British journal of surgery.

[12]  R. Rosati,et al.  Laparoscopic gastroplasty for esophagectomy. , 2005, Rays.

[13]  J. A. Federico,et al.  Minimally invasive esophagectomy: a teaching hospital's first year experience. , 2008, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.

[14]  Simon Law,et al.  Minimally invasive techniques for oesophageal cancer surgery. , 2006, Best practice & research. Clinical gastroenterology.

[15]  Ara Darzi,et al.  Is minimally invasive surgery beneficial in the management of esophageal cancer? A meta-analysis , 2010, Surgical Endoscopy.

[16]  M. Cuesta,et al.  Minimally invasive versus open esophagectomy for cancer: a systematic review and meta-analysis. , 2009, Minerva chirurgica.

[17]  C. Karaliotas,et al.  Minimally Invasive Versus Open Esophagectomy: Meta-Analysis of Outcomes , 2010, Digestive Diseases and Sciences.

[18]  Qun Wang,et al.  Comparison of the short-term quality of life in patients with esophageal cancer after subtotal esophagectomy via video-assisted thoracoscopic or open surgery. , 2009, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.

[19]  A. Watson Operable esophageal cancer: Current results from the West , 1994, World Journal of Surgery.

[20]  W. Richardson,et al.  Laparoscopic hand-assisted versus open transhiatal esophagectomy: a case-control study , 2005, Surgical Endoscopy And Other Interventional Techniques.

[21]  Thai Pham,et al.  Comparison of laparoscopic inversion esophagectomy and open transhiatal esophagectomy for high-grade dysplasia and stage I esophageal adenocarcinoma. , 2009, Archives of surgery.

[22]  A. Esterman,et al.  Minimally invasive versus open esophagectomy for patients with esophageal cancer. , 2009, The Annals of thoracic surgery.

[23]  G. Sanders,et al.  Understanding surgical interventions in RCTs: the need for better methodology , 2013, The Lancet.

[24]  T. Maekawa,et al.  Risk analysis in resection of thoracic esophageal cancer in the era of endoscopic surgery. , 2006, The Annals of thoracic surgery.

[25]  S. Dexter,et al.  Comparison of oncological outcomes after laparoscopic transhiatal and open esophagectomy for T1 esophageal adenocarcinoma , 2008, Surgical Endoscopy.

[26]  P. Senthilnathan,et al.  Minimally invasive oesophagectomy for carcinoma oesophagus--approaches and options in a high volume tertiary centre. , 2010, Journal of the Indian Medical Association.

[27]  E. Wilkinson Cancer Research UK , 2002 .

[28]  P. D. De Leyn,et al.  Minimally invasive esophagectomy for cancer. , 2009, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[29]  G. Buess,et al.  Endoscopic microsurgical dissection of the esophagus (EMDE). , 1997, International surgery.

[30]  K. Reavis,et al.  Outcomes of Esophagectomy According to Surgeon’s Training: General vs. Thoracic , 2008, Journal of Gastrointestinal Surgery.

[31]  I. Braghetto,et al.  Open transthoracic or transhiatal esophagectomy versus minimally invasive esophagectomy in terms of morbidity, mortality and survival , 2006, Surgical Endoscopy And Other Interventional Techniques.

[32]  R. van Hillegersberg,et al.  Minimally invasive surgery compared to open procedures in esophagectomy for cancer: a systematic review of the literature. , 2009, Minerva chirurgica.

[33]  G. Buess,et al.  Endoscopic microsurgical dissection of the esophagus , 2004, Surgical Endoscopy.

[34]  H. Bonjer,et al.  Traditional invasive vs. minimally invasive esophagectomy: a multi-center, randomized trial (TIME-trial) , 2011, BMC surgery.

[35]  A. Barbour,et al.  Thoracoscopic-Assisted Esophagectomy for Esophageal Cancer: Analysis of Patterns and Prognostic Factors for Recurrence , 2010, Annals of surgery.

[36]  A. Rohatgi,et al.  Perioperative outcomes after transition from conventional to minimally invasive Ivor-Lewis esophagectomy in a specialized center , 2010, Surgical Endoscopy.

[37]  Gerhard Prager,et al.  Open versus minimally invasive esophagectomy: a single-center case controlled study , 2010, Surgical Endoscopy.

[38]  M. Cuesta,et al.  Laparoscopically assisted transhiatal resection for malignancies of the distal esophagus , 2004, Surgical Endoscopy And Other Interventional Techniques.

[39]  Mitsuru Sasako,et al.  Randomised trials in surgery: problems and possible solutions , 2002, BMJ : British Medical Journal.

[40]  J. Luketich,et al.  Quality of life after esophageal surgery. , 2004, Thoracic surgery clinics.

[41]  P D Schneider,et al.  Comparison of minimally invasive esophagectomy with transthoracic and transhiatal esophagectomy. , 2000, Archives of surgery.

[42]  K. Hanazaki,et al.  Total laparoscopic gastric mobilization for esophagectomy , 2009, Langenbeck's Archives of Surgery.

[43]  F. Godlee Publishing study protocols: making them visible will improve registration, reporting and recruitment , 2001 .

[44]  Hidetaka Ono,et al.  Video-assisted Thoracoscopic Esophagectomy With a Voice-controlled Robot: The AESOP System , 2004, Surgical laparoscopy, endoscopy & percutaneous techniques.

[45]  J. Hunter,et al.  Comparison of perioperative outcomes after combined thoracoscopic-laparoscopic esophagectomy and open Ivor-Lewis esophagectomy. , 2010, American journal of surgery.

[46]  K. Meredith,et al.  Minimally invasive surgery for esophageal cancer. , 2008, Journal of the National Comprehensive Cancer Network : JNCCN.

[47]  Philip Quirke,et al.  Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial , 2005, The Lancet.

[48]  D. Gotley,et al.  Defining Cure for Esophageal Cancer: Analysis of Actual 5-Year Survivors Following Esophagectomy , 2011, Annals of Surgical Oncology.

[49]  H. Osugi,et al.  A comparison of video‐assisted thoracoscopic oesophagectomy and radical lymph node dissection for squamous cell cancer of the oesophagus with open operation , 2003, The British journal of surgery.

[50]  I. B. Borel Rinkes,et al.  International survey on esophageal cancer: part I surgical techniques. , 2009, Diseases of the esophagus.

[51]  C. Gutschow,et al.  Ivor-Lewis Esophagectomy With and Without Laparoscopic Conditioning of the Gastric Conduit , 2010, World Journal of Surgery.

[52]  D G Altman,et al.  Assessing the quality of randomization from reports of controlled trials published in obstetrics and gynecology journals. , 1994, JAMA.

[53]  J. Blazeby,et al.  The Role of Health-Related Quality of Life Outcomes in Clinical Decision Making in Surgery for Esophageal Cancer: A Systematic Review , 2008, Annals of Surgical Oncology.

[54]  R. Parameswaran,et al.  Comparative Experience of Open and Minimally Invasive Esophagogastric Resection , 2009, World Journal of Surgery.