What if we have too many models of worry and GAD?

It is now almost 40 years since Borkovec and colleagues provided this definition in their seminal paper and so launched the modern psychological study of worry, and by extension generalized anxiety disorder (GAD). Their classic definition has inspired and guided the developments of models and treatments since, and within this definition we can find some of the differences in emphasis between the models as well as the ongoing debates. These include the role of thoughts versus images, the function of worry, the role of affect or emotion, the degree to which worry is controllable, the role of uncertainty, and how worry may relate to fear. Interestingly, this definition appeared in 1983, soon after the arrival of GAD as a diagnostic category in the third edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III; American Psychiatric Association, 1980), following the decision to split the DSM-II (American Psychiatric Association, 1968) category of anxiety neurosis into GAD and panic disorder (see Crocq, 2022, for a historical overview). However, worry as a defining feature did not arrive until DSM-III-R (American Psychiatric Association, 1987). DSM-IV (American Psychiatric Association, 1994) reduced the list of associated symptoms, and the definition of GAD was relatively unaffected by DSM-5 (American Psychiatric Association, 2013). Therefore, we have had a reasonably stable definition of GAD with worry as a defining feature for almost 30 years, and now the 11th edition of the International Statistical Classification of Diseases and Related Health Problems (ICD-11; World Health Organization, 2022) broadly aligns with DSM-5. Despite definitional and diagnostic stability, our understanding of GAD in psychological terms is far from stable.

[1]  O. Hjemdal,et al.  The network structure of dysfunctional metacognition: Analysis of the MCQ-30. , 2022, Acta psychologica.

[2]  Evelyn Behar,et al.  Intolerance of uncertainty and information-seeking behavior: Experimental manipulation of threat relevance. , 2022, Behaviour research and therapy.

[3]  Élizabeth Hébert,et al.  Behavioral Experiments for Intolerance of Uncertainty: A Randomized Clinical Trial for Adults With Generalized Anxiety Disorder. , 2022, Behavior therapy.

[4]  M. Rinck,et al.  Changing Metacognitive Appraisal Bias in High-Worriers Through Reappraisal Training , 2022, Cognitive Therapy and Research.

[5]  T. Ritz,et al.  An Examination of the RDoC Negative Valence Systems Domain Constructs and the Self-Reports Unit of Analysis. , 2022, Behavior therapy.

[6]  C. Chigwedere,et al.  Further development of the intolerance of uncertainty model of GAD: a case series , 2022, The Cognitive Behaviour Therapist.

[7]  T. Rodebaugh,et al.  Personalized networks of social anxiety disorder and depression and implications for treatment. , 2021, Journal of affective disorders.

[8]  C. Krahé,et al.  Internet-delivered interpretation training reduces worry and anxiety in individuals with generalized anxiety disorder: A randomized controlled experiment. , 2021, Journal of consulting and clinical psychology.

[9]  M. Arendt,et al.  Transdiagnostic versus Diagnosis-Specific Group Cognitive Behavioral Therapy for Anxiety Disorders and Depression: A Randomized Controlled Trial. , 2021, Psychotherapy and psychosomatics.

[10]  Chigwedere C A Clinical Experience Informed Variation to the CBT Explanation and Treatment of Worry , 2021, Psychology and Psychotherapy Research Study.

[11]  A. Fisher,et al.  Folk Classification and Factor Rotations: Whales, Sharks, and the Problems With the Hierarchical Taxonomy of Psychopathology (HiTOP) , 2021, Clinical psychological science : a journal of the Association for Psychological Science.

[12]  W. Lutz,et al.  Exploring change in cognitive-behavioral therapy for generalized anxiety disorder-A two-arms ABAB crossed-therapist randomized clinical implementation trial. , 2021, Journal of consulting and clinical psychology.

[13]  D. Watson,et al.  The Development of Preliminary HiTOP Internalizing Spectrum Scales , 2021, Assessment.

[14]  R. Krueger,et al.  Rethinking the Diagnosis of Mental Disorders: Data-Driven Psychological Dimensions, Not Categories, as a Framework for Mental-Health Research, Treatment, and Training , 2021, Current Directions in Psychological Science.

[15]  Isabella M. Palumbo,et al.  Linking RDoC and HiTOP: A new interface for advancing psychiatric nosology and neuroscience. , 2021, Clinical psychology review.

[16]  P. Salkovskis,et al.  Cognitive analysis of specific threat beliefs and safety-seeking behaviours in generalised anxiety disorder: revisiting the cognitive theory of anxiety disorders , 2021, Behavioural and Cognitive Psychotherapy.

[17]  A. Saggino,et al.  On the efficacy of the unified protocol for transdiagnostic treatment of emotional disorders: A systematic review and meta-analysis. , 2021, Clinical psychology review.

[18]  J. Boettcher,et al.  CBT at the Crossroads: The Rise of Transdiagnostic Treatments , 2020, International Journal of Cognitive Therapy.

[19]  A. Rock,et al.  Adult attachment, worry and reassurance seeking: Investigating the role of intolerance of uncertainty , 2020, Clinical Psychologist.

[20]  M. Freeston,et al.  Making friends with uncertainty: experiences of developing a transdiagnostic group intervention targeting intolerance of uncertainty in IAPT. Feasibility, acceptability and implications , 2020, The Cognitive Behaviour Therapist.

[21]  A. Hoffart,et al.  Within-person networks of clinical features of social anxiety disorder during cognitive and interpersonal therapy. , 2020, Journal of anxiety disorders.

[22]  Long-Biao Cui,et al.  The relations among worry, meta-worry, intolerance of uncertainty and attentional bias for threat in men at high risk for generalized anxiety disorder: a network analysis , 2020, BMC Psychiatry.

[23]  Christopher B. Miller,et al.  Efficacy of digital cognitive behavioral therapy for moderate‐to‐severe symptoms of generalized anxiety disorder: A randomized controlled trial , 2020, Depression and anxiety.

[24]  G. Bottesi,et al.  A short-form version of the Intolerance of Uncertainty Scale: Initial development of the IUS-5 , 2020 .

[25]  Mark B. Powers,et al.  Psychological and pharmacological treatments for generalized anxiety disorder (GAD): a meta-analysis of randomized controlled trials , 2020, Cognitive behaviour therapy.

[26]  S. Perrin,et al.  GAD-Specific Cognitive Behavioral Treatment for Children and Adolescents: A Pilot Randomized Controlled Trial , 2019, Cognitive Therapy and Research.

[27]  P. Cuijpers,et al.  Long-term Outcomes of Cognitive Behavioral Therapy for Anxiety-Related Disorders: A Systematic Review and Meta-analysis. , 2019, JAMA psychiatry.

[28]  N. Grey,et al.  Approaching Cognitive Behavior Therapy For Generalized Anxiety Disorder From A Cognitive Process Perspective , 2019, Front. Psychiatry.

[29]  Kuan-Chia Lin,et al.  Pharmacological and psychological interventions for generalized anxiety disorder in adults: A network meta-analysis. , 2019, Journal of psychiatric research.

[30]  B. Dunn,et al.  A commentary on research rigour in clinical psychological science: How to avoid throwing out the innovation baby with the research credibility bath water in the depression field. , 2019, Behaviour research and therapy.

[31]  Élizabeth Hébert,et al.  Behavioral Experiments for Intolerance of Uncertainty: Challenging the Unknown in the Treatment of Generalized Anxiety Disorder , 2019, Cognitive and Behavioral Practice.

[32]  B. Roche,et al.  The Acceptance and Action Questionnaire-II (AAQ-II) as a measure of experiential avoidance: Concerns over discriminant validity , 2019, Journal of Contextual Behavioral Science.

[33]  M. Akbari,et al.  The transdiagnostic model of worry: The mediating role of experiential avoidance , 2018, Personality and Individual Differences.

[34]  Mingyi Qian,et al.  The influence of uncertainty and intolerance of uncertainty on anxiety. , 2018, Journal of behavior therapy and experimental psychiatry.

[35]  C. Botella,et al.  Comorbidity and diagnosis distribution in transdiagnostic treatments for emotional disorders: A systematic review of randomized controlled trials , 2018, PloS one.

[36]  M. Zvolensky,et al.  Refinement of anxiety sensitivity measurement: The Short Scale Anxiety Sensitivity Index (SSASI) , 2018, Psychiatry Research.

[37]  M. Freeston,et al.  Disentangling intolerance of uncertainty and threat appraisal in everyday situations. , 2018, Journal of anxiety disorders.

[38]  Alishia D. Williams,et al.  The Mediating Relationship Between Maladaptive Behaviours, Cognitive Factors, and Generalised Anxiety Disorder Symptoms , 2018, Behaviour Change.

[39]  T. Brown,et al.  The Contribution of Worry Behaviors to the Diagnosis of Generalized Anxiety Disorder , 2018, Journal of psychopathology and behavioral assessment.

[40]  G. Asmundson,et al.  Are anxiety disorders publications continuing on a trajectory of growth? A look at Boschen's (2008) predictions and beyond. , 2018, Journal of anxiety disorders.

[41]  A. Przeworski,et al.  The increase in interest in GAD: Commentary on Asmundson & Asmundson. , 2018, Journal of anxiety disorders.

[42]  D. Tolin,et al.  Remission in CBT for adult anxiety disorders: A meta-analysis. , 2018, Clinical psychology review.

[43]  R. Dar,et al.  Brief therapy for excessive worry: Treatment model, feasibility, and acceptability of a new treatment. , 2017, Journal of Psychotherapy Integration.

[44]  N. Kazantzis,et al.  Systematic review and meta-analysis of dropout rates in individual psychotherapy for generalized anxiety disorder. , 2017, Journal of anxiety disorders.

[45]  L. Greenberg,et al.  Emotion-Focused Therapy for Generalized Anxiety Disorder: An Exploratory Study , 2017, Psychotherapy.

[46]  Thane M. Erickson,et al.  Prospective Investigation of the Contrast Avoidance Model of Generalized Anxiety and Worry. , 2017, Behavior therapy.

[47]  M. Crocq The history of generalized anxiety disorder as a diagnostic category , 2017, Dialogues in clinical neuroscience.

[48]  M. Newman,et al.  Development and validation of two measures of emotional contrast avoidance: The contrast avoidance questionnaires. , 2017, Journal of anxiety disorders.

[49]  Dan J Stein,et al.  Cross-sectional Comparison of the Epidemiology of DSM-5 Generalized Anxiety Disorder Across the Globe , 2017, JAMA psychiatry.

[50]  M. Vasey,et al.  Cognitive Control and Anxious Arousal in Worry and Generalized Anxiety: An Initial Test of an Integrative Model , 2017, Cognitive Therapy and Research.

[51]  David Watson,et al.  The Hierarchical Taxonomy of Psychopathology (HiTOP): A Dimensional Alternative to Traditional Nosologies , 2017, Journal of abnormal psychology.

[52]  L. Timulak,et al.  Developing a model of working with worry in emotion‐focused therapy: A discovery‐phase task analytic study , 2017 .

[53]  R. Baños,et al.  Relative effects of cognitive and behavioral therapies on generalized anxiety disorder, social anxiety disorder and panic disorder: A meta-analysis. , 2016, Journal of anxiety disorders.

[54]  Lucas S. LaFreniere,et al.  A BRIEF ECOLOGICAL MOMENTARY INTERVENTION FOR GENERALIZED ANXIETY DISORDER: A RANDOMIZED CONTROLLED TRIAL OF THE WORRY OUTCOME JOURNAL , 2016, Depression and anxiety.

[55]  W. Mak,et al.  Mindfulness-based cognitive therapy v. group psychoeducation for people with generalised anxiety disorder: Randomised controlled trial , 2016, British Journal of Psychiatry.

[56]  Michael J. Constantino,et al.  Integrating motivational interviewing with cognitive-behavioral therapy for severe generalized anxiety disorder: An allegiance-controlled randomized clinical trial. , 2016, Journal of consulting and clinical psychology.

[57]  L. Timulak,et al.  Emotion-Focused Therapy for Generalized Anxiety Disorder: An Overview of the Model , 2016, Journal of Contemporary Psychotherapy.

[58]  G. Andersson,et al.  Internet-delivered acceptance-based behaviour therapy for generalized anxiety disorder: A randomized controlled trial. , 2016, Behaviour research and therapy.

[59]  A. Przeworski,et al.  Basic Science and Clinical Application of the Contrast Avoidance Model in Generalized Anxiety Disorder , 2014 .

[60]  T. Björgvinsson,et al.  Psychometric properties of abbreviated and ultra-brief versions of the Penn State Worry Questionnaire. , 2014, Psychological assessment.

[61]  Amy Przeworski,et al.  A randomized controlled trial of ecological momentary intervention plus brief group therapy for generalized anxiety disorder. , 2014, Psychotherapy.

[62]  Katherine E Henson,et al.  Risk of Suicide After Cancer Diagnosis in England , 2018, JAMA psychiatry.

[63]  S. Orsillo,et al.  A Contemporary View of Applied Relaxation for Generalized Anxiety Disorder , 2013, Cognitive behaviour therapy.

[64]  D. Mennin,et al.  Emotion Regulation Therapy for Generalized Anxiety Disorder. , 2013, Cognitive and behavioral practice.

[65]  T. Insel,et al.  Toward the future of psychiatric diagnosis: the seven pillars of RDoC , 2013, BMC Medicine.

[66]  A. Przeworski,et al.  Worry and generalized anxiety disorder: a review and theoretical synthesis of evidence on nature, etiology, mechanisms, and treatment. , 2013, Annual review of clinical psychology.

[67]  P. Savard,et al.  Interpretive style and intolerance of uncertainty in individuals with anxiety disorders: a focus on generalized anxiety disorder. , 2012, Journal of anxiety disorders.

[68]  M. Höfler,et al.  AVOIDANCE, SAFETY BEHAVIOR, AND REASSURANCE SEEKING IN GENERALIZED ANXIETY DISORDER , 2012, Depression and anxiety.

[69]  A. Mathews,et al.  A cognitive model of pathological worry , 2012, Behaviour research and therapy.

[70]  S. Hayes,et al.  Preliminary psychometric properties of the Acceptance and Action Questionnaire-II: a revised measure of psychological inflexibility and experiential avoidance. , 2011, Behavior therapy.

[71]  E. Walker,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[72]  M. Newman,et al.  A novel theory of experiential avoidance in generalized anxiety disorder: a review and synthesis of research supporting a contrast avoidance model of worry. , 2011, Clinical psychology review.

[73]  H. Berenbaum An initiation-termination two-phase model of worrying. , 2010, Clinical psychology review.

[74]  F. Mcmanus,et al.  What does a transdiagnostic approach have to offer the treatment of anxiety disorders? , 2010, The British journal of clinical psychology.

[75]  M. Dugas,et al.  Generalized anxiety disorder publications: where do we stand a decade later? , 2010, Journal of anxiety disorders.

[76]  G. Andrews,et al.  Generalized worry disorder: a review of DSM‐IV generalized anxiety disorder and options for DSM‐V , 2010, Depression and anxiety.

[77]  E. Hekler,et al.  Current theoretical models of generalized anxiety disorder (GAD): conceptual review and treatment implications. , 2009, Journal of anxiety disorders.

[78]  G. Davey A Mood-As-Input Account of Perseverative Worrying , 2008 .

[79]  T. Borkovec,et al.  The Cognitive Avoidance Theory of Worry , 2008 .

[80]  M. Boschen Publication trends in individual anxiety disorders: 1980-2015. , 2008, Journal of anxiety disorders.

[81]  A. Kazdin Mediators and mechanisms of change in psychotherapy research. , 2007, Annual review of clinical psychology.

[82]  Cynthia L. Turk,et al.  Applying an Emotion Regulation Framework to Integrative Approaches to Generalized Anxiety Disorder , 2006 .

[83]  S. Orsillo,et al.  Expanding Our Conceptualization of and Treatment for Generalized Anxiety Disorder: Integrating Mindfulness/Acceptance‐Based Approaches With Existing Cognitive‐Behavioral Models , 2006 .

[84]  A. Wells The Metacognitive Model of GAD: Assessment of Meta-Worry and Relationship With DSM-IV Generalized Anxiety Disorder , 2005, Cognitive Therapy and Research.

[85]  D. Clark Developing new treatments: on the interplay between theories, experimental science and clinical innovation. , 2004, Behaviour research and therapy.

[86]  Adrian Wells,et al.  A short form of the metacognitions questionnaire: properties of the MCQ-30. , 2004, Behaviour research and therapy.

[87]  K. L. Gratz,et al.  Multidimensional Assessment of Emotion Regulation and Dysregulation: Development, Factor Structure, and Initial Validation of the Difficulties in Emotion Regulation Scale , 2004 .

[88]  M. Craske,et al.  THE CATASTROPHIZING WORRY PROCESS IN GENERALIZED ANXIETY DISORDER: A PRELIMINARY INVESTIGATION OF AN ANALOG POPULATION , 2003, Behavioural and Cognitive Psychotherapy.

[89]  P. Salkovskis EMPIRICALLY GROUNDED CLINICAL INTERVENTIONS: COGNITIVE-BEHAVIOURAL THERAPY PROGRESSES THROUGH A MULTI-DIMENSIONAL APPROACH TO CLINICAL SCIENCE , 2002, Behavioural and Cognitive Psychotherapy.

[90]  M. Freeston,et al.  CATASTROPHIZING ASSESSMENT OF WORRY AND THREAT SCHEMATA AMONG WORRIERS , 2000, Behavioural and Cognitive Psychotherapy.

[91]  S H Schwartz,et al.  Worries and values. , 2000, Journal of personality.

[92]  A. Wells A Cognitive Model of Generalized Anxiety Disorder , 1999, Behavior modification.

[93]  L. Ost,et al.  Cognitions in generalized anxiety disorder and panic disorder patients. A prospective approach. , 1999, Behaviour research and therapy.

[94]  L. Ost,et al.  Cognitions in generalized anxiety disorder and panic disorder patients. , 1998, Journal of anxiety disorders.

[95]  S. Schwartz,et al.  The structure and dynamics of worry: theory, measurement, and cross-national replications. , 1998, Journal of personality.

[96]  M. Freeston,et al.  Worry themes in primary GAD, secondary GAD, and other anxiety disorders. , 1998, Journal of anxiety disorders.

[97]  M. Freeston,et al.  Generalized anxiety disorder: a preliminary test of a conceptual model. , 1998, Behaviour research and therapy.

[98]  L. Roemer,et al.  An investigation of worry content among generally anxious individuals. , 1997, The Journal of nervous and mental disease.

[99]  A. Wells Meta-Cognition and Worry: A Cognitive Model of Generalized Anxiety Disorder , 1995, Behavioural and Cognitive Psychotherapy.

[100]  Robert Ladouceur,et al.  Why do people worry , 1994 .

[101]  P. de Silva,et al.  Worry and obsessional symptoms: a correlational analysis. , 1992, Behaviour research and therapy.

[102]  R. Noyes,et al.  Generalized anxiety disorder. , 1987, Primary care.

[103]  F. Langlois,et al.  Intolerance of uncertainty and difficulties in emotion regulation: Proposal for an integrative model of generalized anxiety disorder , 2019, European Review of Applied Psychology.

[104]  A. Wenzel Worry and generalized anxiety. , 2011 .

[105]  D. Ohlhorst,et al.  Cross-Sectional Comparison , 2011 .

[106]  K. Bredemeier,et al.  Intolerance of uncertainty and perceived threat. , 2008, Behaviour research and therapy.

[107]  A. Carr,et al.  The handbook of adult clinical psychology : an evidence-based practice approach , 2006 .

[108]  S. Orsillo,et al.  An Acceptance-Based Behavior Therapy for Generalized Anxiety Disorder , 2005 .

[109]  G. Fava,et al.  Psychotherapy and Psychosomatics , 2005 .

[110]  A. Wells A cognitive model of GAD: Metacognitions and pathological worry. , 2004 .

[111]  Evelyn Behar,et al.  Avoidance Theory of Worry and Generalized Anxiety Disorder. , 2004 .

[112]  Robert Ladouceur,et al.  The Role of Intolerance of Uncertainty in Etiology and Maintenance. , 2004 .

[113]  J. Constans,et al.  Stability of worry content in GAD patients: a descriptive study. , 2002, Journal of anxiety disorders.

[114]  M. Dugas Generalized anxiety disorder publications: so where do we stand? , 2000, Journal of anxiety disorders.

[115]  T. Borkovec,et al.  The nature, functions, and origins of worry. , 1994 .

[116]  S. Rachman,et al.  Generalized anxiety disorder (GAD) as an unsuccessful search for safety , 1994 .

[117]  P M Higgins,et al.  COGNITIVE BEHAVIOUR THERAPY FOR PSYCHIATRIC PROBLEMS: A practical guide , 1990 .

[118]  D. Clark,et al.  Anxiety states: Panic and generalized anxiety. , 1989 .

[119]  D. Clark A cognitive approach to panic. , 1986, Behaviour research and therapy.

[120]  S. Rachman,et al.  Agoraphobia--a safety-signal perspective. , 1984, Behaviour research and therapy.

[121]  T. Pruzinsky,et al.  Preliminary exploration of worry: some characteristics and processes. , 1983, Behaviour research and therapy.

[122]  B. Jaffe Cognitive Therapy and the Emotional Disorders , 1977 .

[123]  S. Cartwright-Hatton,et al.  Generalised Anxiety Disorder , 2015 .