Diffuse Interstitial Pulmonary Fibrosis (Hamman–Rich Syndrome) in Infancy: Report of a Case with Histologic and Respiratory Studies

The case of a 7‐month‐old girl with diffuse interstitial pulmonary fibrosis is reported. Signs of progressive respiratory distress with cough and cyanosis started at 1 month of age. Respiratory studies revealed a markedly decreased lung‐compliance, normal or slightly elevated residual lung volume and hyperventilation. There was marked arterial desaturation and this finding together with the respiratory dysfunction is considered typical of interstitial pulmonary fibrosis and is well explained by the biopsy picture of marked collagenous thickening of the alveolo‐capillary septa.

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