Interictal discharges delay target‐directed eye movements and impair attentional set‐shifting in children with epilepsy

The theory of transient cognitive impairment in epilepsy posits that lapses in attention result from ephemeral disruption of attentional circuitry by interictal events. Eye movements are intimately associated with human attention and can be monitored in real time using eye‐tracking technologies. Here, we sought to characterize the associations between interictal epileptiform discharges (IEDs), gaze, and attentional behavior in children with epilepsy.

[1]  Simeon M. Wong,et al.  The anterior and centromedian thalamus: Anatomy, function, and dysfunction in epilepsy , 2022, Epilepsy Research.

[2]  E. Asano,et al.  Temporally and functionally distinct large-scale brain network dynamics supporting task switching , 2022, NeuroImage.

[3]  Jing Wang,et al.  Memory Deficit in Patients With Temporal Lobe Epilepsy: Evidence From Eye Tracking Technology , 2021, Frontiers in Neuroscience.

[4]  Simeon M. Wong,et al.  Phase Resetting in the Anterior Cingulate Cortex Subserves Childhood Attention and Is Impaired by Epilepsy. , 2021, Cerebral cortex.

[5]  R. Chin,et al.  Impaired social attention detected through eye movements in children with early‐onset epilepsy , 2021, Epilepsia.

[6]  L. Billeci,et al.  EYES Are The Window to the Mind: Eye-Tracking Technology as a Novel Approach to Study Clinical Characteristics of ADHD , 2020, Psychiatry Research.

[7]  Jing Wang,et al.  Eye tracking metrics to screen and assess cognitive impairment in patients with neurological disorders , 2020, Neurological Sciences.

[8]  A. Flinker,et al.  Interictal epileptiform discharges shape large-scale intercortical communication , 2019, Brain : a journal of neurology.

[9]  Ueli Rutishauser,et al.  Simultaneous Eye Tracking and Single-Neuron Recordings in Human Epilepsy Patients. , 2019, Journal of visualized experiments : JoVE.

[10]  Eshin Jolly,et al.  Pymer4: Connecting R and Python for Linear Mixed Modeling , 2018, J. Open Source Softw..

[11]  T. Jacobsen,et al.  Selective impairment of attentional set shifting in adults with ADHD , 2018, Behavioral and Brain Functions.

[12]  A. Hunt,et al.  The role of attention in eye-movement awareness , 2018, Attention, perception & psychophysics.

[13]  T. Moore,et al.  Linking ADHD to the Neural Circuitry of Attention , 2017, Trends in Cognitive Sciences.

[14]  T. Banaschewski,et al.  Neurophysiological Correlates of Attentional Fluctuation in Attention-Deficit/Hyperactivity Disorder , 2017, Brain Topography.

[15]  T. Stafford,et al.  Increased microsaccade rate in individuals with ADHD traits , 2017, Journal of eye movement research.

[16]  T. Crawford,et al.  Saccadic Eye Movement Abnormalities in Children with Epilepsy , 2016, PloS one.

[17]  A. Aldenkamp,et al.  Psychiatric and Behavioural Disorders in Children with Epilepsy (ILAE Task Force Report): Epilepsy and ADHD. , 2016, Epileptic disorders : international epilepsy journal with videotape.

[18]  G. Buzsáki,et al.  Interictal epileptiform discharges induce hippocampal-cortical coupling in temporal lobe epilepsy , 2016, Nature Medicine.

[19]  J. Ojemann,et al.  Interictal epileptiform discharge effects on neuropsychological assessment and epilepsy surgical planning , 2016, Epilepsy & Behavior.

[20]  Lucina Q. Uddin,et al.  Demystifying cognitive flexibility: Implications for clinical and developmental neuroscience , 2015, Trends in Neurosciences.

[21]  T. Womelsdorf,et al.  Theta–gamma coordination between anterior cingulate and prefrontal cortex indexes correct attention shifts , 2015, Proceedings of the National Academy of Sciences.

[22]  G. Holmes.  Cognitive impairment in epilepsy: the role of network abnormalities. , 2015, Epileptic disorders : international epilepsy journal with videotape.

[23]  Margot J. Taylor,et al.  Impaired development of intrinsic connectivity networks in children with medically intractable localization‐related epilepsy , 2014, Human brain mapping.

[24]  Margot J. Taylor,et al.  Resilience of developing brain networks to interictal epileptiform discharges is associated with cognitive outcome. , 2014, Brain : a journal of neurology.

[25]  C. Gillberg,et al.  Neurobehavioral Comorbidities in Children With Active Epilepsy: A Population-Based Study , 2014, Pediatrics.

[26]  Margot J. Taylor,et al.  Neuromagnetic correlates of intra- and extra-dimensional set-shifting , 2014, Brain and Cognition.

[27]  Martin Luessi,et al.  MEG and EEG data analysis with MNE-Python , 2013, Front. Neuroinform..

[28]  A. Sever,et al.  Electroencephalogram in Attention Deficit Hyperactivity Disorder: Spike and Wave Paroxysms, Foci, and Seizures , 2013, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[29]  Varda Shalev,et al.  Prevalence of Epilepsy and Attention-Deficit Hyperactivity (ADHD) Disorder , 2013, Journal of child neurology.

[30]  Brian S. Schnitzer,et al.  Eye movements and attention: The role of pre-saccadic shifts of attention in perception, memory and the control of saccades , 2012, Vision Research.

[31]  J. Arends,et al.  The cognitive effects of interictal epileptiform EEG discharges and short nonconvulsive epileptic seizures , 2012, Epilepsia.

[32]  J. Millichap,et al.  Utility of the Electroencephalogram in Attention Deficit Hyperactivity Disorder , 2011, Clinical EEG and neuroscience.

[33]  Christopher K. Kovach,et al.  Manifestation of ocular-muscle EMG contamination in human intracranial recordings , 2011, NeuroImage.

[34]  A. Papanicolaou,et al.  Electroencephalogram Discharges in Atypical Cognitive Development , 2010, Journal of child neurology.

[35]  Marcus Nyström,et al.  An adaptive algorithm for fixation, saccade, and glissade detection in eyetracking data , 2010, Behavior research methods.

[36]  F. Castellanos,et al.  Spontaneous attentional fluctuations in impaired states and pathological conditions: A neurobiological hypothesis , 2007, Neuroscience & Biobehavioral Reviews.

[37]  J. Jolles,et al.  Speed, speed variability, and accuracy of information processing in 5 to 6-year-old children at risk of ADHD , 2005, Journal of the International Neuropsychological Society.

[38]  M. Brammer,et al.  Neural correlates of switching set as measured in fast, event‐related functional magnetic resonance imaging , 2004, Human brain mapping.

[39]  Francisco Barceló,et al.  Spatiotemporal brain dynamics during preparatory set shifting: MEG evidence , 2004, NeuroImage.

[40]  C. Binnie,et al.  Cognitive impairment during epileptiform discharges: is it ever justifiable to treat the EEG? , 2003, The Lancet Neurology.

[41]  Jaroslaw Harezlak,et al.  ADHD and epilepsy in childhood. , 2003, Developmental medicine and child neurology.

[42]  H. Feldman,et al.  Prevalence and assessment of attention-deficit/hyperactivity disorder in primary care settings. , 2001, Pediatrics.

[43]  J M Swanson,et al.  Symptom profiles in children with ADHD: effects of comorbidity and gender. , 2001, Journal of the American Academy of Child and Adolescent Psychiatry.

[44]  T Moore,et al.  Control of eye movements and spatial attention. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[45]  F. Besag,et al.  EFFECTS OF TRANSITORY COGNITIVE IMPAIRMENT ON PSYCHOSOCIAL FUNCTIONING OF CHILDREN WITH EPILEPSY: A THERAPEUTIC TRIAL , 1993, Developmental medicine and child neurology.

[46]  C. Binnie.  Significance and management of transitory cognitive impairment due to subclinical EEG discharges in children , 1993, Brain and Development.

[47]  C D Binnie,et al.  Selective cognitive impairment during focal and generalized epileptiform EEG activity. , 1984, Brain : a journal of neurology.

[48]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[49]  R. Schubert.  Attention deficit disorder and epilepsy. , 2005, Pediatric neurology.

[50]  J. Malagón-Valdéz.  [Cognitive effects of antiepileptic drugs]. , 2003, Revista de neurologia.

[51]  W. Ambrosius,et al.  Behavior problems in children before first recognized seizures. , 2001, Pediatrics.

[52]  Alan C. Evans,et al.  Applications of random field theory to functional connectivity , 1998, Human brain mapping.