Realization of a 15-channel, hermetically-encased wireless subretinal prosthesis for the blind

A miniaturized, hermetically-encased, wirelessly-operated retinal prosthesis has been developed for implantation and pre-clinical studies in Yucatan mini-pig animal models. The prosthesis conforms to the eye and drives a microfabricated polyimide stimulating electrode array with sputtered iridium oxide electrodes. This array is implanted in the subretinal space using a specially-designed ab externo surgical technique that affixes the bulk of the prosthesis to the surface of the sclera. The implanted device includes a hermetic titanium case containing a 15-channel stimulator chip and discrete power supply components. Feedthroughs from the case connect to secondary power- and data-receiving coils. In addition, long-term in vitro pulse testing was performed on the electrodes to ensure their stability for the long lifetime of the hermetic case. The final assembly was tested in vitro to verify wireless operation of the system in biological saline using a custom RF transmitter circuit and primary coils. Stimulation pulse strength, duration and frequency were programmed wirelessly using a custom graphical user interface. Operation of the retinal implant has been verified in vivo in one pig for more than three months by measuring stimulus artifacts on the eye surface using a contact lens electrode.

[1]  Gentiane Venture,et al.  A numerical method for choosing motions with optimal excitation properties for identification of biped dynamics - An application to human , 2009, 2009 IEEE International Conference on Robotics and Automation.

[2]  Joseph F. Rizzo,et al.  Development and Implantation of a Minimally Invasive Wireless Subretinal Neurostimulator , 2009, IEEE Transactions on Biomedical Engineering.

[3]  L.S. Theogarajan.  A Low-Power Fully Implantable 15-Channel Retinal Stimulator Chip , 2008, IEEE Journal of Solid-State Circuits.

[4]  S. J. Kim,et al.  A Suprachoroidal Electrical Retinal Stimulator Design for Long-Term Animal Experiments and In Vivo Assessment of Its Feasibility and Biocompatibility in Rabbits , 2008, Journal of biomedicine & biotechnology.

[5]  P. Preston,et al.  Retinal Neurostimulator for a Multifocal Vision Prosthesis , 2007, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[6]  Krista I Kinard,et al.  Neural reprogramming in retinal degeneration. , 2007, Investigative ophthalmology & visual science.

[7]  P. Troyk,et al.  The influence of electrolyte composition on the in vitro charge-injection limits of activated iridium oxide (AIROF) stimulation electrodes , 2007, Journal of neural engineering.

[8]  J. Weiland,et al.  Visual performance using a retinal prosthesis in three subjects with retinitis pigmentosa. , 2007, American journal of ophthalmology.

[9]  H. Gerding,et al.  Experimental implantation of epiretinal retina implants (EPI-RET) with an IOL-type receiver unit , 2007, Journal of neural engineering.

[10]  Paul J DeMarco,et al.  Stimulation via a subretinally placed prosthetic elicits central activity and induces a trophic effect on visual responses. , 2007, Investigative ophthalmology & visual science.

[11]  R. Jensen,et al.  Responses of ganglion cells to repetitive electrical stimulation of the retina , 2007, Journal of neural engineering.

[12]  R. Hornig,et al.  The IMI Retinal Implant System , 2007 .

[13]  J. Ohta,et al.  The development of a multichannel electrode array for retinal prostheses , 2006, Journal of Artificial Organs.

[14]  Gentiane Venture,et al.  Modeling and Identification of Passenger Car Dynamics Using Robotics Formalism , 2006, IEEE Transactions on Intelligent Transportation Systems.

[15]  Thomas Schanze,et al.  Implantation and testing of subretinal film electrodes in domestic pigs. , 2006, Experimental eye research.

[16]  Z. Moussavi,et al.  Center of Mass Approximation During Walking as a Function of Trunk and Swing Leg Acceleration , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[17]  Philip R. Troyk,et al.  In vitro comparison of the charge-injection limits of activated iridium oxide (AIROF) and platinum-iridium microelectrodes , 2005, IEEE Transactions on Biomedical Engineering.

[18]  P. Jong.  Prevalence of age-related macular degeneration in the United States. , 2004 .

[19]  Benita J. O’Colmain,et al.  Prevalence of age-related macular degeneration in the United States. , 2004, Archives of ophthalmology.

[20]  S. Kelly,et al.  Perceptual efficacy of electrical stimulation of human retina with a microelectrode array during short-term surgical trials. , 2003, Investigative ophthalmology & visual science.

[21]  S. Kelly,et al.  Methods and perceptual thresholds for short-term electrical stimulation of human retina with microelectrode arrays. , 2003, Investigative ophthalmology & visual science.

[22]  C. L. Chen,et al.  Segment inertial properties of Chinese adults determined from magnetic resonance imaging. , 2000, Clinical biomechanics.

[23]  D. Pearsall,et al.  The effect of segment parameter error on gait analysis results. , 1999, Gait & posture.

[24]  P. Leva.  Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. , 1996 .

[25]  M. Gautier,et al.  Exciting Trajectories for the Identification of Base Inertial Parameters of Robots , 1991, [1991] Proceedings of the 30th IEEE Conference on Decision and Control.

[26]  Kathleen M. Robinette,et al.  Anthropometric and Mass Distribution Characteristics of the Adult Female. Revised , 1983 .

[27]  R. Jensen,et al.  Estimation of the biomechanical properties of three body types using a photogrammetric method. , 1978, Journal of biomechanics.