Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells

[1]  N. Pavlova,et al.  The hallmarks of cancer metabolism: Still emerging. , 2022, Cell metabolism.

[2]  P. Oefner,et al.  Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo , 2021, EBioMedicine.

[3]  Jae-Hoon Chang,et al.  AMPK promotes antitumor immunity by downregulating PD-1 in regulatory T cells via the HMGCR/p38 signaling pathway , 2021, Molecular cancer.

[4]  Jae-Hoon Chang,et al.  LKB1-PTEN axis controls Th1 and Th17 cell differentiation via regulating mTORC1 , 2021, Journal of Molecular Medicine.

[5]  Yangzhe Wu,et al.  Metabolites in the Tumor Microenvironment Reprogram Functions of Immune Effector Cells Through Epigenetic Modifications , 2021, Frontiers in Immunology.

[6]  Jae-Hoon Chang,et al.  Geranylgeranyl pyrophosphate amplifies Treg differentiation via increased IL‐2 expression to ameliorate DSS‐induced colitis , 2021, European journal of immunology.

[7]  Gen Li,et al.  Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses , 2021, Nature Cell Biology.

[8]  P. Rochaix,et al.  PD-1 blockade restores helper activity of tumor-infiltrating, exhausted PD-1hiCD39+ CD4 T cells , 2020, JCI insight.

[9]  Z. Cai,et al.  Simultaneous determination of methionine cycle metabolites, urea cycle intermediates and polyamines in serum, urine and intestinal tissue by using UHPLC-MS/MS. , 2020, Talanta.

[10]  Hyunjin Jeong,et al.  A Novel Anti-PD-L1 Antibody Exhibits Antitumor Effects on Multiple Myeloma in Murine Models via Antibody-Dependent Cellular Cytotoxicity , 2020, Biomolecules & therapeutics.

[11]  W. Zou,et al.  Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy. , 2020, Molecular cell.

[12]  Sun-Young Chang,et al.  Plasmacytoid dendritic cells regulate colitis-associated tumorigenesis by controlling myeloid-derived suppressor cell infiltration. , 2020, Cancer letters.

[13]  Y. Zhuang,et al.  PD-1 does not mark tumor-infiltrating CD8+ T cell dysfunction in human gastric cancer , 2020, Journal for ImmunoTherapy of Cancer.

[14]  A. Chinnaiyan,et al.  Cancer SLC43A2 alters T cell methionine metabolism and histone methylation , 2020, Nature.

[15]  E. Richardson,et al.  Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms , 2020, Cancer Gene Therapy.

[16]  M. Lenardo,et al.  A guide to cancer immunotherapy: from T cell basic science to clinical practice , 2020, Nature Reviews Immunology.

[17]  Maxim N. Artyomov,et al.  Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming. , 2020, Cell metabolism.

[18]  Meenakshi S Kagda,et al.  New developments on the Encyclopedia of DNA Elements (ENCODE) data portal , 2019, Nucleic Acids Res..

[19]  Chia-Lin Hsu,et al.  Metabolite Transporters—The Gatekeepers for T Cell Metabolism , 2019, Immunometabolism.

[20]  J. Tegnér,et al.  Exhaustion of CD4+ T-cells mediated by the Kynurenine Pathway in Melanoma , 2019, Scientific Reports.

[21]  Lu Zhang,et al.  CD4+ T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis B , 2019, BMC Immunology.

[22]  M. Kalady,et al.  Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment. , 2019, Cell metabolism.

[23]  Hyewon Seo,et al.  A rapid and sensitive liquid chromatography/tandem mass spectrometry assay for simultaneous quantitation of disopyramide and its major metabolite, mono-isopropyl-disopyramide, in rat plasma and its application to a pharmacokinetic study. , 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[24]  G. Rabinovich,et al.  IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity , 2018, Nature.

[25]  V. Boussiotis,et al.  Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy , 2018, Front. Oncol..

[26]  D. Munn,et al.  Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death. , 2018, Cell metabolism.

[27]  J. Borst,et al.  CD4+ T cell help in cancer immunology and immunotherapy , 2018, Nature Reviews Immunology.

[28]  R. Ke,et al.  Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism , 2018, Cell biology international.

[29]  Yi Fang,et al.  Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation. , 2018, Cancer cell.

[30]  A. Kimmelman,et al.  Metabolic Interactions in the Tumor Microenvironment. , 2017, Trends in cell biology.

[31]  R. Shaw,et al.  AMPK: guardian of metabolism and mitochondrial homeostasis , 2017, Nature Reviews Molecular Cell Biology.

[32]  S. Kaech,et al.  Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries. , 2017, Current opinion in immunology.

[33]  Huahao Shen,et al.  Effectiveness and safety of PD-1/PD-L1 inhibitors in the treatment of solid tumors: a systematic review and meta-analysis , 2017, Oncotarget.

[34]  Takla Griss,et al.  Serine Is an Essential Metabolite for Effector T Cell Expansion. , 2017, Cell metabolism.

[35]  S. Woo,et al.  API5 confers cancer stem cell-like properties through the FGF2-NANOG axis , 2017, Oncogenesis.

[36]  B. Fazekas de St. Groth,et al.  Tumour‐specific CD4 T cells eradicate melanoma via indirect recognition of tumour‐derived antigen , 2016, Immunology and cell biology.

[37]  J. Boss,et al.  Genetic and Epigenetic Regulation of PD-1 Expression , 2016, The Journal of Immunology.

[38]  C. Rudd,et al.  Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8+ Cytolytic T Cell Responses , 2016, Immunity.

[39]  F. Polleux,et al.  AMP-activated protein kinase mediates mitochondrial fission in response to energy stress , 2016, Science.

[40]  J. Michael Cherry,et al.  ENCODE data at the ENCODE portal , 2015, Nucleic Acids Res..

[41]  E. E. Vincent,et al.  The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. , 2015, Immunity.

[42]  Neville E. Sanjana,et al.  Improved vectors and genome-wide libraries for CRISPR screening , 2014, Nature Methods.

[43]  R. Ahmed,et al.  STAT3, STAT4, NFATc1, and CTCF Regulate PD-1 through Multiple Novel Regulatory Regions in Murine T Cells , 2014, The Journal of Immunology.

[44]  Russell G. Jones,et al.  Amino acids fuel T cell-mediated inflammation. , 2014, Immunity.

[45]  F. Brandizzi,et al.  IRE1: ER stress sensor and cell fate executor. , 2013, Trends in cell biology.

[46]  Benjamin E. Gross,et al.  Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal , 2013, Science Signaling.

[47]  Linda V. Sinclair,et al.  Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation , 2013, Nature Immunology.

[48]  David Haussler,et al.  ENCODE Data in the UCSC Genome Browser: year 5 update , 2012, Nucleic Acids Res..

[49]  ENCODEConsortium,et al.  An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.

[50]  J. Asara,et al.  A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue , 2012, Nature Protocols.

[51]  Yi Zhang,et al.  The diverse functions of Dot1 and H3K79 methylation. , 2011, Genes & development.

[52]  E. Wherry,et al.  T-bet represses expression of PD-1 and sustains virus-specific CD8 T cell responses during chronic infection , 2011, Nature Immunology.

[53]  J. Kirkwood,et al.  Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients , 2010, The Journal of experimental medicine.

[54]  E. Gibney,et al.  Epigenetics and gene expression , 2010, Heredity.

[55]  S. Rosenberg,et al.  Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. , 2009, Blood.

[56]  F. Martinon,et al.  BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. , 2009, Molecular cell.

[57]  Tom H. Pringle,et al.  The human genome browser at UCSC. , 2002, Genome research.

[58]  A. T. Phillips Desalting, Concentration, and Buffer Exchange by Dialysis and Ultrafiltration , 1995 .