Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.
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W. Guba | W. Spooren | J. Peters | S. Ceccarelli | T. Hartung | M. Honer | J. Huwyler | E. Borroni | C. Funk | J. Wettstein | Ann C. Petersen | A. Ricci | N. Clemann | E. Prinssen | U. Niederhauser | S. Kolczewski | Manfred Schneider | R. Porter | B. Büttelmann | A. Harrison | L. Lindemann | G. Jaeschke | E. Vieira | Theodor Stoll | J. Wichmann | Nadia Bitter-Stoll | P. Boissin | B. David | Martin Kuratli | A. Pähler | Daniel Rueher | Marianne Rueher | P. Spurr | Daniel Tännler | Antonio Ricci | B. Büttelmann