PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms.
暂无分享,去创建一个
Hong Wu | Daniel J. Freeman | Robert D Cardiff | Gang Wei | R. Cardiff | Gang Wei | Xuan Liu | Hong Wu | A. Whale | N. Rozengurt | Ralf Lesche | R. Lesche | N. Kertesz | Xuan Liu | Nora Rozengurt | Daniel J Freeman | Andrew G Li | Heng-Hong Li | Nathalie Kertesz | Andrew D Whale | Hilda Martinez-Diaz | Andrew G. Li | Heng-Hong Li | H. Martinez-Diaz
[1] G S Taylor,et al. PTEN and myotubularin: novel phosphoinositide phosphatases. , 2001, Annual review of biochemistry.
[2] C. Prives,et al. Functional dissection of p53 tumor suppressor protein. , 1997, Methods in enzymology.
[3] R. Eeles,et al. Allelic imbalance, including deletion of PTEN/MMAC1, at the Cowden disease locus on 10q22‐23, in hamartomas from patients with cowden syndrome and germline PTEN mutation , 1998, Genes, chromosomes & cancer.
[4] A. Levine,et al. Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6 , 1998, Molecular and Cellular Biology.
[5] M. Groszer,et al. Cre/loxP‐mediated inactivation of the murine Pten tumor suppressor gene , 2002, Genesis.
[6] Tomohiko Maehama,et al. Crystal Structure of the PTEN Tumor Suppressor Implications for Its Phosphoinositide Phosphatase Activity and Membrane Association , 1999, Cell.
[7] M. Nelen,et al. Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. , 1997, Human molecular genetics.
[8] L. Mayo,et al. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[9] D. Hanahan,et al. The Hallmarks of Cancer , 2000, Cell.
[10] A. Trumpp,et al. Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the Pten Tumor Suppressor Gene in Vivo , 2001, Science.
[11] R. Parsons,et al. PTEN: life as a tumor suppressor. , 2001, Experimental cell research.
[12] P. Pandolfi,et al. Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. , 2002, Cancer cell.
[13] C. Sawyers,et al. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[14] M. Wigler,et al. The lipid phosphatase activity of PTEN is critical for its tumor supressor function. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[15] T. Liu,et al. Promoter analysis of tumor suppressor gene PTEN: identification of minimum promoter region. , 2002, Biochemical and biophysical research communications.
[16] Yong Liao,et al. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation , 2001, Nature Cell Biology.
[17] L. Chin,et al. Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[18] Jing Li,et al. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome , 1997, Nature Genetics.
[19] J. Manfredi,et al. Multiple roles of the tumor suppressor p53 , 2002, Current opinion in oncology.
[20] Toshiyuki Obata,et al. Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53* , 2002, The Journal of Biological Chemistry.
[21] David R. Kaplan,et al. Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate , 1997, Science.
[22] C. Allis,et al. Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter , 2001, Current Biology.
[23] Hong Wu,et al. Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis. , 2002, Molecular and cellular biology.
[24] B. Hemmings,et al. Inhibition of protein kinase B/Akt. implications for cancer therapy. , 2002, Pharmacology & therapeutics.
[25] Satoshi Matsumoto,et al. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas , 2002, Nature Genetics.
[26] Xuan Liu,et al. Stimulation of p53 DNA Binding by c-Abl Requires the p53 C Terminus and Tetramerization , 2000, Molecular and Cellular Biology.
[27] J. Downward. Mechanisms and consequences of activation of protein kinase B/Akt. , 1998, Current opinion in cell biology.
[28] P. Devreotes,et al. Tumor Suppressor PTEN Mediates Sensing of Chemoattractant Gradients , 2002, Cell.
[29] C. Cordon-Cardo,et al. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[30] Pier Paolo Pandolfi,et al. The Multiple Roles of PTEN in Tumor Suppression , 2000, Cell.
[31] Richard A. Ashmun,et al. Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19 ARF , 1997, Cell.
[32] M. Myers,et al. PTEN: sometimes taking it off can be better than putting it on. , 1997, American journal of human genetics.
[33] H. Wu,et al. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[34] E. Hafen,et al. Living with Lethal PIP3 Levels: Viability of Flies Lacking PTEN Restored by a PH Domain Mutation in Akt/PKB , 2002, Science.
[35] Mammary gland involution is delayed by activated Akt in transgenic mice. , 2001, Molecular endocrinology.
[36] P. Tsichlis,et al. Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[37] W. K. Alfred Yung,et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers , 1997, Nature Genetics.
[38] L. Mayo,et al. The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. , 2002, Trends in biochemical sciences.
[39] M. Wigler,et al. PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer , 1997, Science.
[40] Stefano Colella,et al. Loss of Heterozygosity on Chromosome 10 Is More Extensive in Primary (De Novo) Than in Secondary Glioblastomas , 2000, Laboratory Investigation.
[41] T. Yoshimoto,et al. Functional evaluation of p53 and PTEN gene mutations in gliomas. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[42] Hong Wu,et al. Essential Role of AKT-1/Protein Kinase Bα in PTEN-Controlled Tumorigenesis , 2002, Molecular and Cellular Biology.
[43] J. Dixon,et al. PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy* , 2002, The Journal of Biological Chemistry.
[44] H. Varmus,et al. Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice , 2001, BMC Molecular Biology.
[45] R. McLendon,et al. PTEN gene mutations are seen in high-grade but not in low-grade gliomas. , 1997, Cancer research.
[46] P. Pandolfi,et al. Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse , 2001, Nature Genetics.
[47] R. Parsons,et al. The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. , 1998, Cancer research.
[48] T. Jacks,et al. Insights into cancer from transgenic mouse models , 1999, The Journal of pathology.
[49] Mef Nilbert,et al. Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis , 2002, Cancer.
[50] R. Glazer,et al. Delayed mammary gland involution in MMTV-AKT1 transgenic mice , 2002, Oncogene.
[51] T. Mak,et al. Regulation of PTEN transcription by p53. , 2001, Molecular cell.
[52] D. Goberdhan,et al. Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. , 1999, Genes & development.
[53] C. Glover,et al. Gene expression profiling for hematopoietic cell culture , 2006 .
[54] T. Curran,et al. Identification of redox/repair protein Ref-1 as a potent activator of p53. , 1997, Genes & development.
[55] José Luis de la Pompa,et al. Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN , 1998, Cell.
[56] Carlos Cordon-Cardo,et al. Pten is essential for embryonic development and tumour suppression , 1998, Nature Genetics.
[57] M. Hung,et al. Novel targets of Akt, p21(Cipl/WAF1), and MDM2. , 2002, Seminars in oncology.
[58] Kenneth M. Yamada,et al. Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. , 2001, Journal of cell science.
[59] Tomohiko Maehama,et al. The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate* , 1998, The Journal of Biological Chemistry.
[60] T. Mak,et al. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice , 1998, Current Biology.