From Microdroplets to Microcrystals: Tunable Caffeine Particles by Spray Flash Evaporation

In this work, tunable caffeine crystals are formulated through a promising aerosol-based technology called spray flash evaporation (SFE). In this process, the vacuum atomization of a superheated an...

[1]  G. Van den Mooter,et al.  Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying , 2020, Pharmaceutics.

[2]  Matthew C. Allan,et al.  Relative humidity-temperature transition boundaries for anhydrous β-caffeine and caffeine hydrate crystalline forms. , 2020, Journal of food science.

[3]  D. Spitzer,et al.  Surface characterization of nanoscale co-crystals enabled through tip enhanced Raman spectroscopy. , 2020, Nanoscale.

[4]  Chun‐Sing Lee,et al.  Different Strategies for Organic Nanoparticle Preparation in Biomedicine , 2020 .

[5]  T. Tagami,et al.  Physical Characteristics of Cilostazol–Hydroxybenzoic Acid Cocrystals Prepared Using a Spray Drying Method , 2020 .

[6]  A. Bansal,et al.  Emerging role of primary heterogeneous nucleation in pharmaceutical crystallization , 2019, Drug development research.

[7]  R. Heyler,et al.  Screening a trace amount of pharmaceutical cocrystals by using an enhanced nano‐spot method , 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[8]  Myungwoong Kim,et al.  Readily Functionalizable and Stabilizable Polymeric Particles with Controlled Size and Morphology by Electrospray , 2018, Scientific Reports.

[9]  K. Chua,et al.  Experimental and mathematical study of the spray flash evaporation phenomena , 2018 .

[10]  Benan Cai,et al.  Modeling of spray flash evaporation based on droplet analysis , 2018 .

[11]  Yu Song,et al.  Study on water droplet flash evaporation in vacuum spray cooling , 2017 .

[12]  Sohrab Rohani,et al.  Recent Developments in the Crystallization Process: Toward the Pharmaceutical Industry , 2017 .

[13]  W. Pauer,et al.  Numerical and experimental study of the drying of bi-component droplets under various drying conditions , 2016 .

[14]  D. Spitzer,et al.  Tunable continuous production of RDX from microns to nanoscale using polymeric additives , 2016 .

[15]  W. Cheng,et al.  Spray cooling and flash evaporation cooling: The current development and application , 2016 .

[16]  W. Cheng,et al.  Effect of droplet flash evaporation on vacuum flash evaporation cooling: Modeling , 2015 .

[17]  M. Windbergs,et al.  Overcoming drug crystallization in electrospun fibers--Elucidating key parameters and developing strategies for drug delivery. , 2015, International journal of pharmaceutics.

[18]  D. Spitzer,et al.  Continuous engineering of nano-cocrystals for medical and energetic applications , 2014, Scientific Reports.

[19]  Xiao Dong Chen,et al.  Multiscale modeling for surface composition of spray‐dried two‐component powders , 2014 .

[20]  H. Muhr,et al.  Continuous formation of submicron energetic particles by the flash-evaporation technique , 2012 .

[21]  S. Pratsinis,et al.  Design of nanomaterial synthesis by aerosol processes. , 2012, Annual review of chemical and biomolecular engineering.

[22]  M. J. Cocero,et al.  Crystallization of Caffeine by Supercritical Antisolvent (SAS) Process: Analysis of Process Parameters and Control of Polymorphism , 2012 .

[23]  Jingkang Wang,et al.  Caffeine Crystallization Induction Time Measurements Using Laser Scattering Technique and Correlation to Surface Tension in Water and Ethanol , 2010 .

[24]  Su-Jin Park,et al.  Recrystallization of caffeine using gas antisolvent process , 2008 .

[25]  G. Castanet,et al.  Composition measurement of bicomponent droplets using laser-induced fluorescence of acetone , 2007 .

[26]  Wei Zhang,et al.  Progress in Drying Technology for Nanomaterials , 2005 .

[27]  K. Johnston,et al.  Micronized powders of a poorly water soluble drug produced by a spray-freezing into liquid-emulsion process. , 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[28]  P. Arlabosse,et al.  Drying droplet as a template for solid formation: A review , 2020 .

[29]  A. Kelly,et al.  Synthesis of Caffeine/Maleic Acid Co-crystal by Ultrasound-assisted Slurry Co-crystallization. , 2017, Journal of pharmaceutical sciences.

[30]  H. Edwards,et al.  Metamorphosis of caffeine hydrate and anhydrous caffeine , 1997 .