Tissue- and cell type-specific expression of cytochrome P450 1A1 and cytochrome P450 1A2 mRNA in the mouse localized in situ hybridization.

[1]  D. Nebert,et al.  Markedly increased constitutive CYP1A1 mRNA levels in the fertilized ovum of the mouse. , 1998, Biochemical and biophysical research communications.

[2]  D. Phelan,et al.  Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin. , 1998, Archives of biochemistry and biophysics.

[3]  P. Thomas,et al.  Distribution and induction of cytochrome P450 1A1 and 1A2 in rat brain. , 1998, Toxicology and applied pharmacology.

[4]  E. Brittebo,et al.  Localization of cytochrome P4501A1 and covalent binding of a mutagenic heterocyclic amine in blood vessel endothelia of rodents. , 1998, Toxicology.

[5]  R. Peterson,et al.  Responsiveness of the adult male rat reproductive tract to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: Ah receptor and ARNT expression, CYP1A1 induction, and Ah receptor down-regulation. , 1998, Toxicology and applied pharmacology.

[6]  G. Gervasini,et al.  Modulation of CYP1A2 enzyme activity by indoleamines: inhibition by serotonin and tryptamine. , 1998, Pharmacogenetics.

[7]  D. Nebert,et al.  Phospholipase A2 activation and increases in specific prostaglandins in the oxidatively stressed 14CoS/14CoS mouse hepatocyte line. , 1998, Biochemical pharmacology.

[8]  A. Puga,et al.  Constitutive Activation of the Aromatic Hydrocarbon Receptor , 1998, Molecular and Cellular Biology.

[9]  J. Bend,et al.  Aryl hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells. , 1997, Molecular pharmacology.

[10]  S. Anttila,et al.  Detection of mRNA encoding xenobiotic‐metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes , 1997, Molecular carcinogenesis.

[11]  H. Yamazaki,et al.  Oxidation of xenobiotics by recombinant human cytochrome P450 1B1. , 1997, Drug metabolism and disposition: the biological fate of chemicals.

[12]  F. Carlotti,et al.  Regulation of the CYP1A1 promoter in transgenic mice: an exquisitely sensitive on-off system for cell specific gene regulation. , 1996, Journal of cell science.

[13]  H. Yamazaki,et al.  Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1. , 1996, Cancer research.

[14]  H. Shichi,et al.  In situ hybridization of Cyp1a1, Cyp1a2 and Ah receptor mRNAs expressed in murine ocular tissues. , 1996, Experimental eye research.

[15]  D W Nebert,et al.  Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[16]  D W Nebert,et al.  P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. , 1996, Pharmacogenetics.

[17]  D. Flesch‐Janys,et al.  Exposure to polychlorinated dioxins and furans (PCDD/F) and mortality in a cohort of workers from a herbicide-producing plant in Hamburg, Federal Republic of Germany. , 1995, American journal of epidemiology.

[18]  E. Gallagher,et al.  Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity. , 1995, Pharmacogenetics.

[19]  G. Clark,et al.  Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent expression in livers and kidneys of TCDD-treated animals. , 1995, Carcinogenesis.

[20]  S. Shiff,et al.  Expression of cytochrome P450 mRNAs in the colon and the rectum in normal human subjects. , 1995, Biochemical and biophysical research communications.

[21]  S. Otto,et al.  Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a unique tissue- specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation , 1995, The Journal of Biological Chemistry.

[22]  H. Shichi,et al.  Immunocytochemical study of cytochrome P450 (1A1/1A2) induction in murine ocular tissues. , 1995, Experimental eye research.

[23]  K. Husgafvel‐Pursiainen,et al.  Pretranslational induction of cytochrome P4501A enzymes by beta-naphthoflavone and 3-methylcholanthrene occurs in different liver zones. , 1994, Biochemical pharmacology.

[24]  J. Albrecht,et al.  Induction of cytochrome CYPIA1 and formation of toxic metabolites of benzo[a]pyrene by rat aorta: a possible role in atherogenesis. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[25]  D. Nebert Drug-metabolizing enzymes in ligand-modulated transcription. , 1994, Biochemical pharmacology.

[26]  C. J. Omiecinski,et al.  Regiospecific expression of cytochrome P-450s and microsomal epoxide hydrolase in human brain tissue. , 1993, Journal of toxicology and environmental health.

[27]  V. Vasiliou,et al.  Role of the Ah Receptor and the Dioxin‐Inducible [Ah] Gene Battery in Toxicity, Cancer, and Signal Transduction a , 1993, Annals of the New York Academy of Sciences.

[28]  P. Traber,et al.  Induction of cytochrome P450IA genes (CYP1A) by omeprazole in the human alimentary tract. , 1992, Gastroenterology.

[29]  D. Nebert,et al.  The murine Cyp1a-1 gene negatively regulates its own transcription and that of other members of the aromatic hydrocarbon-responsive [Ah] gene battery. , 1990, Molecular endocrinology.

[30]  C. Omiecinski,et al.  Induction and developmental expression of cytochrome P450IA1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction. , 1990, Cancer research.

[31]  D. Waxman,et al.  Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. , 1990, The Journal of biological chemistry.

[32]  M. Maines,et al.  Differential regulation of heme and drug metabolism in rat testis and prostate: response to cis-platinum and human chorionic gonadotropin. , 1990, The Journal of pharmacology and experimental therapeutics.

[33]  J. Stegeman,et al.  Cytochrome P450IA1 induction and localization in endothelium of vertebrate (teleost) heart. , 1989, Molecular pharmacology.

[34]  D. Nebert,et al.  Cell-specific induction of mouse Cyp1a1 mRNA during development. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[35]  F. Gonzalez,et al.  The molecular biology of cytochrome P450s. , 1988, Pharmacological reviews.

[36]  R. Levi,et al.  Heart as a target organ in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity: decreased beta-adrenergic responsiveness and evidence of increased intracellular calcium. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[37]  R. Dubey,et al.  Localization and characterization of drug-metabolizing enzymes along the villus-crypt surface of the rat small intestine--II. Conjugases. , 1988, Biochemical pharmacology.

[38]  F. Oesch,et al.  Xenobiotic metabolizing enzymes are not restricted to parenchymal cells in rat liver. , 1987, Molecular pharmacology.

[39]  D. Nebert,et al.  Tissue-specific expression of the mouse dioxin-inducible P(1)450 and P(3)450 genes: differential transcriptional activation and mRNA stability in liver and extrahepatic tissues , 1986, Molecular and cellular biology.

[40]  K. Shiromizu,et al.  The effect of intraovarian injection of benzo(a)pyrene on primordial oocyte number and ovarian aryl hydrocarbon [benzo(a)pyrene] hydroxylase activity. , 1984, Toxicology and applied pharmacology.

[41]  D. Melton,et al.  Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. , 1984, Nucleic acids research.

[42]  D. Nebert,et al.  The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences. , 1984, The Journal of biological chemistry.

[43]  R. Angerer,et al.  Detection of mrnas in sea urchin embryos by in situ hybridization using asymmetric RNA probes. , 1984, Developmental biology.

[44]  Eric F. Johnson,et al.  Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital on the occurrence and distribution of four cytochrome P-450 isozymes in rabbit kidney, lung, and liver. , 1982, Cancer research.

[45]  F. Guengerich,et al.  Effects of 3-methylcholanthrene, beta-naphthoflavone, and phenobarbital on the 3-methylcholanthrene-inducible isozyme of cytochrome P-450 within centrilobular, midzonal, and periportal hepatocytes. , 1982, The Journal of biological chemistry.

[46]  D. M. Angevine,et al.  Infertility in mice exposed in utero to benzo(a)pyrene. , 1981, Biology of reproduction.

[47]  R. Levitt,et al.  The Ah locus: biochemical basis for genetic differences in brain tumor formation in mice. , 1979, Genetics.

[48]  F. Guengerich,et al.  Immunohistochemical localizations of cytochromes P-450 in rat liver. , 1978, Life sciences.

[49]  L. Wattenberg Carcinogen-detoxifying mechanisms in the gastrointestinal tract. , 1966, Gastroenterology.

[50]  R. Edwards,et al.  The mutagenicity of benzo[a]pyrene in mouse small intestine. , 1999, Carcinogenesis.

[51]  K. Lindros,et al.  Zonation of hepatic cytochrome P-450 expression and regulation. , 1998, The Biochemical journal.

[52]  C. J. Omiecinski,et al.  Expression of cytochrome P450s and microsomal epoxide hydrolase in primary cultures of human umbilical vein endothelial cells. , 1994, Toxicology and applied pharmacology.

[53]  L. Kaminsky,et al.  Small intestinal cytochromes P450. , 1991, Critical reviews in toxicology.

[54]  J. Overstreet,et al.  Xenobiotic metabolizing enzyme activities in rat, mouse, monkey, and human testes. , 1991, Drug metabolism and disposition: the biological fate of chemicals.

[55]  D. Rosenberg,et al.  Tissue-specific induction of the carcinogen inducible cytochrome P450 isoform, P450IAI, in colonic epithelium. , 1991, Archives of biochemistry and biophysics.

[56]  D W Nebert,et al.  The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects. , 1989, Critical reviews in toxicology.

[57]  R. Angerer,et al.  Demonstration of tissue-specific gene expression by in situ hybridization. , 1987, Methods in enzymology.