Macrophage heterogeneity in liver injury and fibrosis.

[1]  D. Hume,et al.  IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1 , 2013, The Journal of experimental medicine.

[2]  R. Schwabe,et al.  Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice , 2013, Hepatology.

[3]  P. Libby,et al.  Local proliferation dominates lesional macrophage accumulation in atherosclerosis , 2013, Nature Medicine.

[4]  T. Luedde,et al.  Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis , 2013, The Journal of Immunology.

[5]  P. Taylor,et al.  Distinct bone marrow-derived and tissue resident macrophage-lineages proliferate at key stages during inflammation , 2013, Nature Communications.

[6]  D. Schuppan,et al.  Evolving therapies for liver fibrosis. , 2013, The Journal of clinical investigation.

[7]  A. Mildner,et al.  Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. , 2013, Immunity.

[8]  S. Curbishley,et al.  Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics , 2013, Hepatology.

[9]  A. Bast,et al.  The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice. , 2013, Gastroenterology.

[10]  J. Fallowfield,et al.  Edinburgh Research Explorer Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis Differential Ly-6C expression identi fi es the recruited macrophage phenotype, which orchestrates the regression of murine liver fi brosis , 2022 .

[11]  Christian Trautwein,et al.  Functional Role of Monocytes and Macrophages for the Inflammatory Response in Acute Liver Injury , 2012, Front. Physio..

[12]  F. Tacke,et al.  Peptide-functionalized gold nanorods increase liver injury in hepatitis. , 2012, ACS nano.

[13]  S. Makhzami,et al.  Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. , 2012, Journal of hepatology.

[14]  John P Iredale,et al.  Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP‐12) during experimental liver fibrosis , 2012, Hepatology.

[15]  N. Van Rooijen,et al.  Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[16]  S. Milani,et al.  Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis , 2012, Clinical science.

[17]  J. Pollard,et al.  A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells , 2012, Science.

[18]  T. Luedde,et al.  Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C‐C motif chemokine receptor 8 in mice , 2012, Hepatology.

[19]  F. Tacke,et al.  Modification of chemokine pathways and immune cell infiltration as a novel therapeutic approach in liver inflammation and fibrosis. , 2011, Inflammation & allergy drug targets.

[20]  T. Wynn,et al.  Protective and pathogenic functions of macrophage subsets , 2011, Nature Reviews Immunology.

[21]  T. Luedde,et al.  Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury , 2011, Gut.

[22]  F. Finkelman,et al.  Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation , 2011, Science.

[23]  D. Hume,et al.  Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function , 2011, Hepatology.

[24]  T. Luedde,et al.  NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma , 2011, Nature Reviews Gastroenterology &Hepatology.

[25]  T. Luedde,et al.  The fractalkine receptor CX3CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes , 2010, Hepatology.

[26]  T. Luedde,et al.  Functional Contribution of Elevated Circulating and Hepatic Non-Classical CD14+CD16+ Monocytes to Inflammation and Human Liver Fibrosis , 2010, PloS one.

[27]  Claudio Lottaz,et al.  Comparison of gene expression profiles between human and mouse monocyte subsets. , 2010, Blood.

[28]  R. Schwabe,et al.  CCR2 promotes hepatic fibrosis in mice , 2009, Hepatology.

[29]  F. Ginhoux,et al.  Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis , 2009, Hepatology.

[30]  L. Rénia,et al.  Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice. , 2009, The American journal of pathology.

[31]  A. Smith,et al.  Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis , 2009, PLoS pathogens.

[32]  J. Edwards,et al.  Exploring the full spectrum of macrophage activation , 2008, Nature Reviews Immunology.

[33]  R. Pierce,et al.  Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages. , 2007, Blood.

[34]  R. Schwabe,et al.  Gene expression profiles during hepatic stellate cell activation in culture and in vivo. , 2007, Gastroenterology.

[35]  J. Fallowfield,et al.  Scar-Associated Macrophages Are a Major Source of Hepatic Matrix Metalloproteinase-13 and Facilitate the Resolution of Murine Hepatic Fibrosis1 , 2007, The Journal of Immunology.

[36]  R. Schwabe,et al.  TLR4 enhances TGF-beta signaling and hepatic fibrosis. , 2007, Nature medicine.

[37]  S. Forbes,et al.  Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. , 2005, The Journal of clinical investigation.

[38]  Y. Sasaguri,et al.  Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats. , 2005, Gastroenterology.

[39]  P. Olinga,et al.  Targeting dexamethasone to Kupffer cells: Effects on liver inflammation and fibrosis in rats , 2001, Hepatology.

[40]  S. Milani,et al.  Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration. , 1998, The American journal of pathology.

[41]  Makoto Naito,et al.  Development, differentiation, and maturation of Kupffer cells , 1998, Microscopy research and technique.